Anti-emetic drug effects on pilot performance: Granisetron vs. ondansetron

Aviation Space and Environmental Medicine

Volumn 68, Issue 11, 1997, Pages 998-1005

  Benline, Terry A ^a,c   French, Jonathan ^b   Poole, Eric ^b  

^a Systems Research Lab Inc   (United States)

^b AIR FORCE RESEARCH LABORATORY   (United States)

^c USAF   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEMETIC AGENT; GRANISETRON; ONDANSETRON; PLACEBO;

ADULT; AIR FORCE; AIRPLANE PILOT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FLIGHT; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PERFORMANCE; SIMULATOR; VOMITING;

ADMINISTRATION, ORAL; ADULT; AEROSPACE MEDICINE; AFFECT; ANTIEMETICS; ATTENTION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG MONITORING; GRANISETRON; HUMANS; MALE; MILITARY PERSONNEL; MOTION SICKNESS; ONDANSETRON; PSYCHOMOTOR PERFORMANCE;

EID: 0030828535     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Benline TA, French J, Wing J. Anti-emetic drug effects on performance-Phase I: Laboratory study. Brooks AFB, TX: Armstrong Laboratory, 1995. Report No.: AL/CF-TR1995-0146.
2. Henriksson R, Lomberg H, Israelsson G, et al. The effect of ondansetron on radiation-induced emesis and diarrhea. Acta Oncol 1992; 31:767-9.
3. Hunter AE, Prentice HG, Pothecary K, et al. Granisetron, a selective 5-HT3 receptor antagonist, for the prevention of radiation induced emesis during total body irradiation. Bone Marrow Transplant 1991; 7:439-41.
4. Kidgell AE, Butcher ME, Brown GW. Antiemetic control: 5-HT3 antagonists: review of clinical results, with particular emphasis on ondansetron. Cancer Treat Review 1990; 17:311-7.
5. Lip H. Ondansetron, a new antiemetic therapy for oncology. Scand J Gastroenterol 1990; 178:55-61.
6. Logue JP, Magee B, Hunter RD, Murdoch RD. The anti-emetic effect of granisetron in lower hemibody radiotherapy. Clin Oncol 1991; 3:247-9.
7. McNair DM, Lorr M, Droppleman LF. Profile of mood states. San Diego, CA: Educational and Industrial Testing Service, 1971.
8. Plosker GL, Goa KL. Granisetron: a review of its pharmacological properties and therapeutic use as an anti-emetic drug. Drugs 1992; 42:805-24.
9. Priestman TJ. Clinical studies with ondansetron in the control of radiation-induced emesis. Eur J Cancer Clin Oncol 1989; 25:S29-33.
10. Roberts JT, Priestman TJ. A review of ondansetron in the management of radiotherapy-induced emesis. Oncology 1993; 50:173-9.
11. Scarantino CW, Ornitz RD, Huffman LG, Anderson RF. Radiationinduced emesis: effects of ondansetron. Semin Oncol 1992; 19:38-43.
12. Seynaeve C, Verweij J, de Mulder PH. 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granisetron and tropisetron. Anticancer Drugs 1991; 2:343-55.
13. Smith RN. Safety of ondansetron. Eur J Cancer Clin Oncol 1989; 25:S47-S50.
14. Stewart DJ. Cancer therapy, vomiting and antiemetics. Can J Physiol Pharmacol 1990; 68:304-23.
15. Storm WF, French J, Bisson RU, et al. Crew performance and fatigue during sustained B-1 B sorties. Brooks AFB, TX: Armstrong Laboratory, 1995. Report No.: AL/CF-TR-1994-0014 (In press).
16. Thomas M, Geltmacher H. Combat simulator diplay development. Information Display 1993; 9:23-6.
17. Tyers MB. Pharmacology and preclinical antiemetic properties of ondansetron. Semin Oncol 1992; 19:1-8.
18. Tyers MB, Bunce KT, Humphrey PP. Pharmacological and antiemetic properties of ondansetron. Eur J Cancer Clin Oncol 1989; 25:S15-9.