Molecular modeling and 3D-QSAR studies on the interaction mechanism of tripeptidyl thrombin inhibitors with human α-thrombin

Journal of Medicinal Chemistry

Volumn 40, Issue 19, 1997, Pages 3085-3090

  Jiang, Hualiang ^a   Chen, Kaixian ^a   Tang, Yun ^a   Chen, Jianzhong ^a   Li, Quan ^a   Wang, Qinmi ^a   Ji, Ruyun ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE PROTEINASE INHIBITOR; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; BINDING SITE; CALCULATION; CARDIOVASCULAR DISEASE; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; PROTEIN CONFORMATION; STATISTICAL ANALYSIS; STRUCTURE ACTIVITY RELATION; THROMBOSIS;

ANTITHROMBINS; BINDING SITES; CALORIMETRY; COMPUTER GRAPHICS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; THROMBIN;

EID: 0030828455     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960309m     Document Type: Article

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