Dual function of the copR gene product of plasmid pIP501

Journal of Bacteriology

Volumn 179, Issue 22, 1997, Pages 7016-7024

  Brantl, Sabine ^a   Wagner, E Gerhart H ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ARTICLE; DNA SUPERCOILING; ENZYME INHIBITION; GENE DELETION; GENE FUNCTION; GENE REPLICATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; RNA TRANSCRIPTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 0030827623     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.22.7016-7024.1997     Document Type: Article

References (33)

1. Anagnostopoulos, C., and J. Spizizen. 1961. Requirements for transformation in Bacillus subtilis. J. Bacteriol. 81:741-746.
2. Behnke, D., H. Malke, M. Hartmann, and F. Walter. 1979. Post-transformational rearrangement of an in vitro reconstructed group-A streptococcal erythromycin resistance plasmid. Plasmid 2:605-616.
3. Behnke, D., M. S. Gilmore, and J. J. Ferretti. 1981. Plasmid pGB301, a new multiple resistance streptococcal cloning vehicle and its use in cloning of a gentamicin/kanamycin resistance determinant. Mol. Gen. Genet. 182:414-421.
4. Blomberg, P., E. G. H. Wagner, and K. Nordström. 1990. Control of replication of plasmid R1: the duplex between the antisense RNA, CopA, and its target, CopT, is processed specifically in vivo and in vitro by RNaseIII. EMBO J. 9:2331-2340.
5. Bowater, R. P., D. Chen, and D. M. J. Lilley. 1994. Modulation of tyrT promoter activity by template supercoiling in vivo. EMBO J. 13:5647-5655.
6. Bowater, R. P., D. Chen, and D. M. Lilley. 1994. Elevated unconstrained supercoiling of plasmid DNA generated by transcription and translation of the tetracycline resistance gene in eubacteria. Biochemistry 33:9266-9275.
7. Brantl, S. 1994. The CopR protein of plasmid pIP501 acts as transcriptional repressor at the essential repR promoter. Mol. Microbiol. 14:473-483.
8. Brantl, S. Unpublished data.
9. Brantl, S., D. Behnke, and J. C. Alonso. 1990. Molecular analysis of the replication region of the conjugative Streptococcus agalactiae plasmid pIP501 in Bacillus subtilis. Comparison with plasmids pAMβ1 and pSM19035. Nucleic Acids Res. 18:4783-4790.
10. Brantl, S., and D. Behnke. 1992. Copy number control of the streptococcal plasmid pIP501 occurs at three levels. Nucleic Acids Res. 20:395-400.
11. Brantl, S., and D. Behnke. 1992. The amount of RepR protein determines the copy number of plasmid pIP501 in Bacillus subtilis. J. Bacteriol. 174: 5474-5478.
12. Brantl, S., E. Birch-Hirschfeld, and D. Behnke. 1993. RepR protein expression on plasmid pIP501 is controlled by an antisense RNA-mediated transcription attenuation mechanism. J. Bacteriol. 175:4052-4061.
13. Brantl, S., and E. G. H. Wagner. 1994. Antisense RNA-mediated transcriptional attenuation occurs faster than stable antisense/target RNA pairing: an in vitro study of plasmid pIP501. EMBO J. 13:3599-3607.
14. Brantl, S., and E. G. H. Wagner. 1996. An unusually long-lived antisense RNA in plasmid copy number control: in vivo RNAs encoded by the streptococcal plasmid pIP501. J. Mol. Biol. 255:275-288.
15. Clewell, D. B., Y. Yagi, G. M. Dunny, and S. K. Schultz. 1974. Characterization of three plasmid deoxyribonucleic acid molecules in a strain of Streptococcus faecalis: identification of a plasmid determining erythromycin resistance. J. Bacteriol. 117:283-289.
16. del Solar, G., and M. Espinosa. 1992. The copy number of plasmid pSL1 is regulated by two trans-acting plasmid products: the antisense RNAII and the repressor protein, RepA. Mol. Microbiol. 6:83-94.
17. del Solar, G., P. Acebo, and M. Espinosa. 1995. Replication control of plasmid pSL1: efficient regulation of plasmid copy number is exerted by the combined action of two plasmid components, CopG and RNAII. Mol. Microbiol. 18:913-924.
18. del Solar, G., P. Acebo, and M. Espinosa. 1997. Replication control of plasmid pLS1: the antisense RNAII and the compact mall region are involved in translational regulation of the initiator RepB synthesis. Mol. Microbiol. 23:95-108.
19. Free, A., and C. J. Dorman. 1994. Escherichia coli tyrT gene transcription is sensitive to DNA supercoiling in its native chromosomal context: effect of DNA topoisomerase IV overexpression on tyrT promoter. Mol. Microbiol. 14:151-161.
20. Horodniceanu, T., D. H. Bouanchaud, G. Bieth, and Y. A. Chabbert. 1976. R-plasmids in Streptococcus agalactiae (group B). Antimicrob. Agents Chemother. 10:795-801.
21. Kawamura, F., and R. H. Doi. 1984. Construction of a Bacillus subtilis double mutant deficient in extracellular alkaline and neutral proteases. J. Bacteriol. 160:442-444.
22. Kok, J., J. M. B. van der Vossen, and G. Venema. 1984. Construction of plasmid cloning vectors for lactic streptococci which also replicate in Bacillus subtilis and Escherichia coli. Appl. Environ. Microbiol. 48:726-731.
23. Le Chatelier, E., S. D. Ehrlich, and L. Janniere. 1994. The pAMβ1 Cop repressor regulates plasmid copy number by controlling transcription of the repE gene. Mol. Microbiol. 14:463-471.
24. Le Chatelier, E., S. D. Ehrlich, and L. Janniere. 1996. Countertranscript-driven attenuation system of the pAMβ1 repE gene. Mol. Microbiol. 20: 1099-1112.
25. Light, J., E. Riise, and S. Molin. 1985. Transcription and its regulation in the basic replicon region of plasmid R1. Mol. Gen. Genet. 198:503-508.
26. Liu, L. F., and J. C. Wang. 1987. Supercoiling of the DNA template during transcription. Proc. Natl. Acad. Sci. USA 84:7024-7027.
27. Nordström, K., S. Molin, and J. Light. 1984. Control of replication of bacterial plasmids: genetics, molecular biology and physiology of the plasmid R1 system. Plasmid 12:71-90.
28. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
29. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
30. Söderbom, F. Unpublished data.
31. Spirito, F., and L. Bossi. 1996. Long-distance effect of downstream transcription on activity of the supercoiling-sensitive leu-500 promoter in a topA mutant of Salmonella typhimurium. J. Bacteriol. 178:7129-7137.
32. Steiner, K., and H. Malke. 1995. Transcription termination of the streptokinase gene of Streptococcus equisimilis H46A: bidirectionality and efficiency in homologous and heterologous hosts. Mol. Gen. Genet. 246:374-380.
33. Stougaard, P., J. Light, and S. Molin. 1982. Convergent transcription interferes with expression of the copy number control gene, CopA, from plasmid R1. EMBO J. 1:323-328.