A pump-prime aprotinin dose in cardiac surgery: Appraisal of its effects on the hemostatic system

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 11, Issue 7, 1997, Pages 835-839

  Rossi, Marco ^a   Storti, Sergio ^a   Martinelli, Lorenzo ^a   Varano, Carmelita ^a   Marra, Roberto ^a   Zamparelli, Roberto ^a   Possati, Gianfederio ^a   Schiavello, Rocco ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Aprotinin; Bleeding; Cardiopulmonary bypass; Fibrinolysis; Transfusion

Indexed keywords

ANTIPLASMIN; ANTITHROMBIN III; APROTININ; BLOOD CLOTTING FACTOR 7; D DIMER; FIBRIN DEGRADATION PRODUCT; FIBRINOGEN; PLASMIN; PROTHROMBIN; THROMBIN;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; MALE; PARTIAL THROMBOPLASTIN TIME; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; REOPERATION;

EID: 0030827605     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-0770(97)90116-6     Document Type: Article

References (24)

1. Woodman RC, Harker LA: Bleeding complications associated with cardiopulmonary bypass. Blood 76:1680-1693, 1990
2. Murphy WG, Davies HJ, Eduardo A: The hemostatic response to surgery and trauma. Br J Anaesth 70:205-213, 1993
3. Tanaka K, Takao M, Yada I, et al: Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypass during open heart surgery. J Cardiothorac Anaesth 3:181-188, 1989
4. Rinder CS, Bonhert J, Rinder HM, et al: Platelet activation and aggregation during CPB. Anesthesiology 75:388-397, 1991
5. Levy JH, Kelly AB: Inflammation and CPB. Can J Anaesth 40:1009-1015, 1993
6. Kirklin JK: Prospects for understanding and eliminating the deleterious effects of CPB. Ann Thorac Surg 51:529-531, 1991
7. Von Segesser LK, Turina M: CPB without systemic heparinization. Performance of heparin-coated oxygenators in comparison with classic membrane and bubble oxygenators. J Thorac Cardiovasc Surg 98:386-396, 1989
8. Von Segesser LK, Weiss BM, Garcia E, et al: Reduction and elimination of systemic heparinization during CPB. J Thorac Cardiovasc Surg 103:790-798, 1992
9. Gravlee GP: Heparin-coated cardiopulmonary bypass circuit. J Cardiothorac Vasc Anaesth 8:213-222, 1994
10. Salzmann EW, Weinstein HJ, Weintraub RM, et al: Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. N Engl J Med 314:1402-1406, 1986
11. Horrow JC, Hlavacek J, Strong MD, et al: Prophylactic tranexamic acid decreases bleeding after cardiac operations. J Thorac Cardiovasc Surg 99:70-74, 1990
12. Del Rossi A, Cernaianu AC, Botros S, et al: Prophylactic treatment of postperfusion bleeding using EACA. Chest 96:27-30, 1989
13. Fish KJ, Sarnquist FH, van Steennis C, et al: A prospective, randomized study of the effects of prostacyclin on PLT and blood loss during coronary bypass operations. J Thorac Cardiovasc Surg 91:436-442, 1986
14. Hardy JF, Desroches J: Natural and synthetic antifibrinolytics in cardiac surgery. Can J Anaesth 39:353-365, 1992
15. Royston D: High-dose aprotinin therapy: A review of the first five years' experience. J Cardiothorac Vasc Anaesth 6:76-100, 1992
16. Havel M, Teufelsbauer H, Knobl P, et al: Effect of intraoperative aprotinin administration on postoperative bleeding in patients undergoing CPB. J Thorac Cardiovasc Surg 101:968-972, 1991
17. Marx G, Pokar H, Doering V et al: The effects of aprotinin on haemostatic function during cardiac surgery. J Cardiothorac Vasc Anaesth 5:467-474, 1991
18. Whitten CW, Latson TW, Allison PM, et al: Does aprotinin inhibit cardiopulmonary bypass-induced inflammation? Anesthesiology 77:A266, 1992
19. Blauhut B, Gross C, Necek S, et al: Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement and renal function after CPB. J Thorac Cardiovasc Surg 101:958-967, 1991
20. Lavee J, Savion N, Smolinsky A, et al: Platelet protection by aprotinin in CPB: Electron microscopy study. Ann Thorac Surg 53:477-481, 1992
21. van Oeveren W, Harder MP, Roozendaal KJ, et al: Aprotinin protects platelets against the initial effect of CPB. J Thorac Cardiovasc Surg 99:788-797, 1990
22. Mohr R, Goor D, Lusky A, et al: Aprotinin prevents cardiopulmonary bypass-induced platelet dysfunction. Circulation 86:405-409, 1992 (suppl II)
23. Huang H, Ding W, Su Z, et al: Mechanism of the preserving effect of aprotinin on platelet function and its use in cardiac surgery. J Thorac Cardiovasc Surg 106:11-18, 1993
24. Royston D: Intraoperative coronary thrombosis: Can aprotinin be incriminated? J Cardiothorac Vasc Anaesth 8:137-141, 1994