Effects of peroral alanine administration in lactating ewes with decreased availability of glucose

British Journal of Nutrition

Volumn 78, Issue 5, 1997, Pages 805-813

  Holtenius, Kjell ^a   Holtenius, Paul ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

hydroxybutyrate; Alanine; Pancrease

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALANINE; AMINO ACID; FATTY ACID; GLUCAGON; GLUCOSE; PHLORIZIN;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BOVIDS; CORRELATION FUNCTION; ENERGY BALANCE; FATTY ACID BLOOD LEVEL; FEMALE; GLUCONEOGENESIS; GLUCOSE OXIDATION; KETOGENESIS; LACTATION; LIPOLYSIS; NONHUMAN; PROTEIN DEGRADATION; SHEEP;

3-HYDROXYBUTYRIC ACID; ADMINISTRATION, ORAL; ALANINE; ANALYSIS OF VARIANCE; ANIMALS; CROSS-OVER STUDIES; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCAGON; GLUCOSE; HYDROXYBUTYRATES; INSULIN; LACTATION; PHLORHIZIN; REGRESSION ANALYSIS; SHEEP;

ANIMALIA; BOVIDAE; OVIS; OVIS ARIES;

EID: 0030827552     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN19970196     Document Type: Article

References (33)

1. Amaral-Phillips, D. M., McGilliard, A. D., Lindberg, G. L., Veenhuizen, J. J. & Young, J. W. (1993). Effects of decreased availability of glucose for dairy cows. Journal of Dairy Science 76, 752-761.
2. Bergman, E. N. & Hogue, D. E. (1967). Glucose turnover and oxidation rates in lactating sheep. American Journal of Physiology 213, 1378-1384.
3. Breukink, H. J. & Wensing, T. H. (1992). Disorders in the dairy cow as a consequence of production. In Proceedings of the 8th International Conference on Production Diseases in Farm Animals, pp. 123-135. [J. Blaum, editor]. Berne, Switzerland: University of Berne.
4. Brockman, R. P. & Bergman, E. N. (1975). Effect of glucagon on plasma alanine and glutamine metabolism and hepatic gluconeogenesis in sheep. American Journal of Physiology 228, 1627-1633.
5. Brockman, R. P., Bergman, E. N., Joo, P. K. & Manns, J. G. (1975). Effects of glucagon and insulin on net hepatic metabolism of glucose precursors in sheep. American Journal of Physiology 229, 1344-1350.
6. Chi, L. M., Muller, J. & Schafer, M. (1973). Zum verhalten der freien Aminosauren bei subklinischer Ketose der Milchkuhe (Behaviour of free amino acids in blood plasma of cows with subclinical ketosis). Archiv für Experimentelle Veterinarmedizin 27, 583-587.
7. Egan, A. R., McRay, J. C. & Lamb, C. S. (1983). Threonine metabolism in sheep. 1. Threonine catabolism and gluconeogenesis in mature Blackface wethers given poor quality hill herbage. British Journal of Nutrition 49, 373-383.
8. Felig, P. (1975). Amino acid metabolism in man. Annual Review of Biochemistry 44, 933-955.
9. Funovics, J., Roth, E., Muhlbacher, F., Schultz, F., Karner, J., Schultis, K., Ogris, E. & Fritsch, A. (1981). Alanin als stickstoffsparendes und glukoneogenetisches Substrat im postoperativen Zustand (Alanine as nitrogen sparing and gluconeogenic substrate in the postoperative state). Klinische Wochenschrift 59, 797-802.
10. Giudicelli, Y., Janvier, B., Nordmann, J. & Nordmann, R. (1976). Inhibition of free fatty acid release from the isolated rat epididymal fat cells by some natural occurring organic acids. Biomedicine 25, 376-381.
11. Hedge, G. A., Coby, H. D. & Goodman, R. L. (1987). Clinical Endocrine Physiology 1st ed. Philadelphia: W. B. Saunders Co.
12. Heitmann, R. N. & Bergman, E. N. (1980). Integration of amino acid metabolism in sheep: effects of fasting and acidosis. American Journal of Physiology 239, E248-E254.
13. Herdt, T. H. & Emery, R. R. (1992). Therapy of diseases of ruminant intermediary metabolism. Veterinary Clinics of North America: Food Animal Practice 8, 91-106.
14. Horsburgh, T., Cannon, J. K. & Pitts, R. F. (1978). Action of phlorizin on luminal and antiluminal membranes of proximal cells of the kidney. American Journal of Physiology 234, F485-F489.
15. Koeslag, J. H., Levinrad, L. I., Lochner, J. V. & Siven, A. A. (1985). Post-exercise ketosis in post-prandial exercise: effect of glucose and alanine ingestion in humans. Journal of Physiology 358, 395-403.
16. Kuhara, T., Ikeda, S., Ohneda, A. & Sasaki, Y. (1991). Effects of intravenous infusion of 17 amino acids on the secretion of GH, glucagon, and insulin in sheep. American Journal of Physiology 260, E21-E26.
17. Ozand, P. T., Reed, W. D., Hawkins, R. L., Stevenson, J. H., Tildon, J. T. & Cornblath, M. (1977). Effect of L-alanine infusion on gluconeogenesis and ketogenesis in the rat in vivo. Biochemical Journal 170, 583-591.
18. Radcliffe, A. G., Wolfe, R. R., Colpoys, M. F., Muhlbacher, F. & Wilmore, D. W. (1983). Ketone-glucose interaction in fed, fasted, and fasted-infected sheep. American Journal of Physiology 244, R667-R675.
19. Reed, D. W., Baab, P. J., Hawkins, R. L. & Ozand, P. T. (1984). A double-isotope method for the measurement of ketone-body turnover in the rat. Biochemical Journal 219, 15-24.
20. Reynolds, C. K. & Huntington, G. B. (1988). Partition of portal-drained visceral net flux in beef steers. Net flux of volatile fatty acids, D-β-hydroxybutyrate and L-lactate across stomach and post-stomach tissues. British Journal of Nutrition 60, 553-562.
21. Reynolds, C. K. & Tyrrell, H. F. (1991). Effects of mesenteric vein L-alanine infusion on liver metabolism in beef heifers fed on diets differing in forage:concentrate ratio. British Journal of Nutrition 66, 437-450.
22. Robinson, A. M. & Williamson, D. H. (1980). Physiological roles of ketone bodies as substrates and signals in mammal tissues. Physiological Reviews 60, 143-187.
23. Rossini, A. A., Aoki, T. T., Ganda, A. O., Soeldner, J. S. & Cahill, G. F. (1975). Alanine-induced amino acid interrelationships. Metabolism 24, 1185-1192.
24. Sherwin, R. S., Hendler, R. G. & Felig, P. (1975). Effect of ketone infusions on amino acid and nitrogen metabolism in man. Journal of Clinical Investigation 55, 1382-1390.
25. Spörndly, R. (1995). Fodertabeller for idisslare (Feeding Tables for Ruminants). Uppsala: Swedish University of Agricultural Sciences.
26. Thompson, J. R. & Wu, G. (1991). The effect of ketone bodies on nitrogen metabolism in skeletal muscle (review). Comparative Biochemistry and Physiology 100B, 209-219.
27. Umpleby, A. M., Chubb, D., Boroujerdi, M. A. & Sonksen, P. H. (1988). The effect of ketone bodies on leucine and alanine metabolism in dogs. Clinical Science 74, 41-48.
28. Umpleby, A. M., Scobie, I. N., Boroujerdi, M. A. & Sönksen, P. H. (1995). The effect of starvation on leucine, alanine and glucose metabolism in obese subjects. European Journal of Clinical Investigation 25, 619-626.
29. Weik, H. & Zander, H. D. (1975). Der Einfluss von Alanine auf die Acetonämie der Milchkuh und auf die phlorizin-induzierte Acetonämie des Schafes (Effect of alanine on acetonaemia in the dairy cow and on phlorizin-induced acetonaemia in the sheep). Zentralblat für Veterinärmedizin A22, 520-523.
30. Williamson, D. H. (1985). D-Alanine: determination with alanine dehydrogenase. In Methods of Enzymatic Analysis, vol. 8, pp. 341-344 [H. U. Bergmeyer, editor]. New York: Academic Press.
31. Wu, J. R. & Thompson, J. R. (1988). Effect of ketone bodies on alanine and glutamine metabolism in chick skeletal muscle. Biochemical Journal 225, 139-144.
32. Zammit, V. A. (1981). Intrahepatic regulation of ketogenesis. Trends in Biochemical Science 6, 46-49.
33. Zander, H. D. (1976). Die kunstliche Erzeugung der Ketosis beim laktierenden Milchschaf durch Phlorizininfusion (Artificial induction of ketosis in lactating ewes by infusion of phlorizin). Berliner und Munchener Tierarztliche Wochenschrift 89, 5-7.