Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease

Brain Research

Volumn 772, Issue 1-2, 1997, Pages 9-22

  Passani, Lucius A ^a,b   Vonsattel, Jean Paul G ^a   Coyle, Joseph T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Cerebral cortex; Glutamate; Huntington's disease; Microglia; N Acetylaspartylglutamate; Peptide; Striatum

Indexed keywords

N ACETYLASPARTYLGLUTAMIC ACID;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; TEMPORAL CORTEX;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; BRAIN CHEMISTRY; BRAIN MAPPING; BRAIN STEM; CASE-CONTROL STUDIES; CEREBRAL CORTEX; DIPEPTIDES; FEMALE; HUMANS; HUNTINGTON DISEASE; MALE; MIDDLE AGED; NEUROPEPTIDES; REFERENCE VALUES; SPINAL CORD;

EID: 0030827379     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00784-1     Document Type: Article

References (66)

1. Andine P., Sandberg M., Bagenholm R., Lehmann A., Hagberg H. Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic-ischaemia. Dev. Brain Res. 64:1991;115-120.
2. Antuono P., Koller K.J., Whitehouse P.J., Price D.L., Coyle J.T. N-Acetyl-aspartyl-glutamate (NAAG) distribution in Alzheimer's disease (AD). Neurology. 35:1985;183.
3. Beal M.F. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31:1992;119-130.
4. Beal M.F. Huntington's disease, energy, and excitotoxicity. Neurobiol. Aging. 15:1994;275-276.
5. R.D. Blakely, J.T. Coyle, The neurobiology of N-acetylaspartylglutamate, in: J.R. Smythies, R. Bradley (Eds.), International Review of Neurobiology, Academic Press, New York, 1988, pp. 39-100.
6. Blakely R.D., Ory-Lavolee L., Grzanna R., Koller K.J., Coyle J.T. Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate. Brain Res. 402:1987;373-378.
7. Blakely R.D., Robinson M.B., Thompson R.C., Coyle J.T. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate: subcellular and regional distribution, ontogeny and the effects of lesions on N-acetylated-alpha-linked acidic dipeptidase activity. J. Neurochem. 50:1988;1200-1209.
8. Braak H., Braak E., Bohl J. Staging of Alzheimer related cortical destruction. Eur. Neurol. 33:1993;403-408.
9. Chessell I.P., Francis P.T., Pangalos M.N., Pearson R.C., Bowen D.M. Localisation of muscarinic (m1) and other neurotransmitter receptors on corticofugal-projecting pyramidal neurons. Brain Res. 632:1993;86-94.
10. Cheung S.T., Lim R. Isolation of γ-glutamylaspartic acid and α-aspartylalanine from pig brain. Biochim. Biophys. Acta. 586:1979;418-424.
11. Evans P.D., Reale V., Merzon R.M., Villegas J. N-Methyl-D-aspartate (NMDA) and non-NMDA (metabotropic) type glutamate receptors modulate the membrane potential of the Schwann cell of the squid giant nerve fibre. J. Exp. Biol. 173:1992;229-249.
12. Fabricius M., Jensen L.H., Lauritzen M. Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex. Brain Res. 612:1993;61-69.
13. Fonnum F., Lund Karlsen R., Malthe-Sorenssen D., Skrede K., Walaas I. Localization of neurotransmitters, particularly glutamate, in hippocampus, septum, nucleus accumbens and superior colliculus. Prog. Brain Res. 51:1979;167-191.
14. Fonnum F., Storm-Mathisen J., Divac I. Biochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibers in rat brain. Neuroscience. 6:1981;863-873.
15. Forloni G., Grzanna R., Blakely D., Coyle J.T. Co-localization of N-acetylaspartylglutamate in central cholinergic, noradrenergic and serotonergic neurons. Synapse. 1:1987;455-460.
16. Galli T., Godeheu G., Artaud F., Desce J.M., Pittaluga A., Barbeito L., Glowinski J., Cheramy A. Specific role of N-acetyl-aspartyl-glutamate in the in vivo regulation of dopamine release from dendrites and nerve terminals of nigrostriatal dopaminergic neurons in the cat. Neuroscience. 42:1991;19-28.
17. P.S. Goldman-Rakic, L.D. Selemon, Topography of corticostriatal projections in nonhuman primates and implications for functional parcellation of the neostriatum, in: E.G. Jones, A. Peters (Eds.), Cerebral Cortex, Plenum Press, New York, 1986, pp. 447-466.
18. Grunze H.C., Rainnie D.G., Hasselmo M.E., Barkai E., Hearn E.F., McCarley R.W., Greene R.W. NMDA-dependent modulation of CA1 local circuit inhibition. J. Neurosci. 16:1996;2034-2043.
19. Hof P.R., Cox K., Morrison J.H. Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease. I. Superior frontal and inferior temporal cortex J. Comp. Neurol. 301:1990;44-54.
20. Jaarsma D., Veenma-van der Duin L., Korf J. N-Acetylaspartate and N-acetylaspartylglutamate levels in Alzheimer's disease post-mortem brain tissue. J. Neurol. Sci. 127:1994;230-233.
21. E.G. Jones, Laminar distribution of cortical efferent cells, in: A. Peters, E.G. Jones (Eds.), Cerebral Cortex, Plenum Press, New York, 1984, pp. 521-553.
22. Kakimoto Y., Nakajima T., Kanazawa A., Takesada M., Sano I. Isolation of γ-L-glutamyl-L-glutamic acid and γ-L-glutamyl-L-glutamine from bovine brain. Biochim. Biophys. Acta. 93:1964;333-338.
23. Kanazawa A., Kakimoto Y., Nakajima T., Sano I., Shimizu H., Takesada M. Isolation and identification of γ-L-glutamylglycine from bovine brain. Biochim. Biophys. Acta. 97:1965;460-464.
24. Karkela J.T. Critical evaluation of postmortem changes in human autopsy cisternal fluid. Enzymes, electrolytes, acid-base balance, glucose and glycolysis, free amino acids and ammonia. Correlation to total brain ischaemia. J. Forensic Sci. 38:1993;603-616.
25. Kharazia V.N., Weinberg R.J. Glutamate in thalamic fibers terminating in layer IV of primary sensory cortex. J. Neurosci. 14:1994;6021-6032.
26. Künzle H. Bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia. An autoradiographic study in Macaca fascicularis. Brain Res. 88:1975;195-209.
27. Lähdesmäki P., Winter R. A peptide containing aspartic acid, glutamic acid and serine in calf brain synaptic vesicles. Acta Chem. Scand. B. 31:1977;802-806.
28. Lowe S.L., Bowen D.M., Francis P.T., Neary D. Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease. Neuroscience. 38:1990;571-577.
29. McCaman M., Stetzler J. Identification of an acidic dipeptide, β-aspartylglycine, in the CNS of Aplysia. J. Neurochem. 43:1984;1375-1384.
30. Meyerhoff J.L., Carter R.C., Yourick D.L., Slusher B.S., Coyle J.T. Genetically epilepsy-prone rats have increased brain regional activity of an enzyme which liberates glutamate from N-acetyl-aspartyl-glutamate. Brain Res. 593:1992;140-143.
31. Moffett J.R., Namboodiri M.A., Neale J.H. Enhanced carbodiimide fixation for immunohistochemistry: application to the comparative distributions of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat brain. J. Histochem. Cytochem. 41:1993;559-570.
32. Moffett J.R., Namboodiri M.A.A. Differential distribution of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat forebrain. J. Neurocytol. 24:1995;409-433.
33. Moffett J.R., Palkovits M., Namboodiri M.A.A., Neale J.H. Comparative distribution of N-acetylaspartylglutamate and GAD(67) in the cerebellum and precerebellar nuclei of the rat utilizing enhanced carbodiimide fixation and immunohistochemistry. J. Comp. Neurol. 347:1994;598-618.
34. L.A. Passani, J.G. Vonsattel, R.E. Carter, J.T. Coyle, N-Acetylaspartylglutamate, N-acetylaspartate and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington's disease and Alzheimer's disease, Mol. Chem. Neuropathol., in press.
35. Perry T.L., Hansen S. What excitotoxin kills striatal neurons in Huntington's disease? Clues from neurochemical studies. Neurology. 40:1990;20-24.
36. Pow D.V., Crook D.K. Rapid postmortem changes in the cellular localisation of amino acid transmitters in the retina as assessed by immunocytochemistry. Brain Res. 653:1994;199-209.
37. 3H]norepinephrine release from rat hippocampal slices. J. Pharmacol. Exp. Ther. 266:1993;796-803.
38. Reichelt K.L. The isolation of gamma-glutamyl peptides from monkey brain. J. Neurochem. 17:1969;19-25.
39. Reichelt K.L., Fonnum F. Subcellular localization of N-acetylaspartylglutamate, N-acetylglutamate and glutathione in brain. J. Neurochem. 16:1969;1409-1416.
40. Reichelt K.L., Kvamme E. Acetylated and peptide bound glutamate and aspartate in brain. J. Neurochem. 14:1967;987-996.
41. Robinson M., Blakely S., Couto R., Coyle J.T. Hydrolysis of the brain peptide N-acetyl-L-aspartyl-L-glutamate. J. Biol. Chem. 262:1987;14498-14506.
42. Sekiguchi M., Okamoto K., Sakai Y. Low-concentration N-acetylaspartylglutamate suppresses the climbing fibre response of Purkinje cells in guinea pig cerebellar slices and the response to excitatory amino acids of Xenopus laevis oocytes injected with cerebellar mRNA. Brain Res. 482:1989;87-96.
43. Sekiguchi M., Wada K., Wenthold R.J. N-Acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes. FEBS Lett. 311:1992;285-289.
44. Selemon L.D., Goldman-Rakic P. Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey. J. Neurosci. 5:1985;776-794.
45. Sotrel A., Paskevich P.A., Kiely D.K., Bird E.D., Williams R.S., Myers R.H. Morphometric analysis of the prefrontal cortex in Huntington's disease. Neurology. 41:1991;1117-1123.
46. Sotrel A., Williams R.S., Kaufmann W.E., Myers R.H. Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington's disease: a quantitative Golgi study. Neurology. 43:1993;2088-2096.
47. Terry R.D., Peck A., De Terese R., Schlechter R., Horoupian D.S. Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann. Neurol. 10:1981;184-192.
48. Tieman S.B., Cangro C.B., Neale J.H. N-Acetylaspartylglutamate immunoreactivity in neurons of the cat's visual system. Brain Res. 420:1987;188-193.
49. Tieman S.B., Moffett J.R., Irtenkauf S.M. Effect of eye removal on N-acetylaspartylglutamate immunoreactivity in retinal targets of the cat. Brain Res. 562:1991;318-322.
50. Tieman S.B., Neale J.H., Tieman D.G. N-Acetylaspartylglutamate immunoreactivity in neurons of the monkey's visual pathway. J. Comp. Neurol. 313:1991;45-64.
51. Tsai G., Passani L., Slusher B., Carter R., Baer L., Kleinman J., Coyle J. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Arch. Gen. Psychiatry. 52:1995;829-836.
52. Tsai G., Slusher B., Sim L., Hedreen J.C., Rothstein J.D., Kuncl R., Coyle J.T. Reductions in acidic amino acids and N-acetyl-aspartyl-glutamate in amyotrophic lateral sclerosis CNS. Brain Res. 556:1991;151-156.
53. Tsai G., Slusher B.S., Sim L., Coyle J.T. Immunocytochemical distribution of N-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways. J. Chem. Neuroanat. 6:1993;277-292.
54. Tsai G., Stauch B.L., Vornov J.J., Deshpande J.K., Coyle J.T. Selective release of N-acetylaspartylglutamate from rat optic nerve terminals in vivo. Brain Res. 518:1990;313-316.
55. Varga V., Janaky R., Marnela K.-M., Gulyas J., Kontro P., Oja S.S. Displacement of excitatory amino acid receptor ligands by acidic oligopeptides. Neurochem. Res. 14:1989;1223-1227.
56. Varga V., Janaky R., Saransaari P., Oja S.S. Endogenous gamma-L-glutamyl and beta-L-aspartyl peptides and excitatory aminoacidergic neurotransmission in the brain. Neuropeptides. 27:1994;19-26.
57. V. Varga, K.-M. Marnela, P. Kontro, Effects of acidic dipeptides on aminoacidergic neurotransmission in the brain, in: R.J. Huxtable, F. Franconi, A. Giotti (Eds.), The Biology of Taurine. Methods and Mechanisms, Plenum Press, New York, 1987, pp. 357-368.
58. Vonsattel J., Aizawa H., Ge P., DiFiglia M., McKee A.C., MacDonald M., Gusella J.F., Landwehrmeyer B., Bird E.D., Richardson E.P. Jr., Hedley-Whyte E.T. An improved approach to prepare human brains for research. J. Neuropathol. Exp. Neurol. 54:1995;42-56.
59. Vonsattel J.-P., Myers R.H., Stevens T.J., Ferrante R.J., Bird E.D., Richardson E.P. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44:1985;559-577.
60. Watson R.E., Wiegand S.J., Clough R.W., Hoffman G.E. Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology. Peptides. 7:1986;155-159.
61. Westbrook G.L., Mayer M.L., Namboodiri M.A., Neale J.H. High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture. J. Neurosci. 6:1986;3385-3392.
62. Williamson L.C., Neale J.H. Calcium-dependent release of N-acetylaspartylglutamate from retinal neurons upon depolarization. Brain Res. 475:1988;151-155.
63. Wroblewska B., Wroblewski J.T., Saab O.H., Neale J.H. N-Acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells. J. Neurochem. 61:1993;943-948.
64. Xing L.C., Tieman S.B. Relay cells, not interneurons, of cat's lateral geniculate nucleus contain N-acetylaspartylglutamate. J. Comp. Neurol. 330:1993;272-285.
65. Zollinger M., Amsler U., Do K.Q., Streit P., Ceunod M. Release of N-acetyl-aspartylglutamate on depolarization of rat brain slices. J. Neurochem. 51:1988;1919-1923.
66. Zollinger M., Brauchlitheotokis J., Gutteckamsler U., Do K.Q., Streit P., Cuenod M. Release of N-acetylaspartylglutamate from slices of rat cerebellum, striatum, and spinal cord, and the effect of climbing fiber deprivation. J. Neurochem. 63:1994;1133-1142.