Antigenic variation of the Epstein-Barr virus nuclear antigen EBNA1 as revealed by monoclonal antibodies

Virus Research

Volumn 50, Issue 2, 1997, Pages 139-149

  Iwakiri, Dai ^a   Nakamura, Hiroyuki ^a   Ono, Yasushi ^a   Fujiwara, Shigeyoshi ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigenic variation; EBNA1; Epstein Barr virus; Monoclonal antibodies

Indexed keywords

CELL NUCLEUS ANTIGEN; EPITOPE; MONOCLONAL ANTIBODY; VIRUS ANTIGEN;

ANIMAL CELL; ANTIGENIC VARIATION; ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENIC VARIATION; BURKITT LYMPHOMA; CALLITHRIX; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNODOMINANT EPITOPES; TUMOR CELLS, CULTURED;

ANIMALIA; HUMAN HERPESVIRUS 4;

EID: 0030826817     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(97)00065-8     Document Type: Article

References (30)

1. Ambinder, R.F., Shah, W.A., Rawklins, D.R., Hayward, G.S., Hayward, S.D., 1991. Definition of the sequence requirements for binding ofthe EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA. J. Virol. 64, 2369-2379.
2. Bhatia, K., Raji, A., Gutierrez, M.I., Judde, J-G., Spangler, G., Venkatesh, H., Magrath, I.T., 1996. Variation in the sequence of Epstein-Barr virus nuclear antigen 1 in normal peripheral blood lymohocytes and in Burkitt's lymphomas. Oncogene 13, 177-181.
3. Chen, M-R., Middeldorp, J.M., Hayward, S.D., 1993. Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure. J. Virol. 67, 4875-4885.
4. Falk, K., Gratama, J.W., Rowe, M., Zou, J.Z., Khamin, F., Young, L.S., Oosteveer, M.A.P., Ernberg, I., 1995. The role of repetitive DNA sequences in the size variation of Epstein-Barr virus (EBV) nuclear antigens, and the identification of different EBV isolates using RFLP and PCR analysis. J. Gen. Virol. 76, 779-790.
5. Fujiwara, S., Fisher, R.J., Bhat, N.K., Diaz de la Espina, S.M., Papas, T.S., 1988. A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C. Mol. Cell Biol. 8, 4700-4706.
6. Fujiwara, S., Koizumi, S., Fisher, R.J., Bhat, N.K., Papas, T.S., 1990. Monoclonal antibodies specific to human ets-2 oncoprotein: Recognition of epitopes clustered on the B domein. Hybridoma 9, 559-571.
7. Gergely, L., Sternas, L., Dillner, J., Klein, G., 1984. Molecular size variation of EBNA1 is determined by the EB viral genome. Intervirology 22, 85-96.
8. Grässer, F.A., Murray, P.G., Kremmer, E., Klein, K., Remberger, K., Feiden, W., Reynolds, G., Niedobitek, G., Young, L.S., Mueller-Lantzsch, N., 1994. Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): Immunohistiologic detection of EBNA1 in the malignant cells of Hodgkin's disease. Blood 84, 3792-3798.
9. Gregory, C.D., Rowe, D.M., Rickinson, A.B., 1990. Different Epstein-Barr virus (Epstein-Barr virus) B-cell interactions in phenotypically distinct clones of a Burkitt lymphoma cell line. J. Gen. Virol. 71, 1481-1495.
10. Harlow, E., Lane, D. 1988. Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, pp. 341.
11. Harling, J.C., Lewis, A., Levine, A.J., 1985. Structure of Epstein-Barr virus nuclear antigen as probed with monoclonal antibodies. Virology 142, 215-220.
12. Hinuma, Y., Konn, M., Yamaguchi, J., Wudarski, D., Blakeslee, J., Grace, J., 1967. Immunofluorescence and herpes type virus particles in the P3HR-1 Burkitt lymphoma gene. J. Virol. 1, 1045-1051.
13. Imai, S., Koizumi, S., Sugiura, M., Tokunaga, M., Uemura, Y., Yamamoto, N., Tanaka, S., Satoh, E., Osato, T., 1994. Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc. Natl. Acad. Sci. USA 91, 9131-9135.
14. Inoue, N., Harada, S., Honma, T., Kitamura, T., Yanagi, K., 1991. The domain of Epstein-Barr virus nuclear antigen 1 essential for binding to oriP region has a hypothetical basic -helix-loop-helix structure. Virology 182, 84-93.
15. Kieff, E., 1996. Epstein-Barr Virus and its replication. In: Fields, B.N. (Ed.), Virology, 3rd edn., Lippincott-Racen, Philadelphia, pp. 2343-2396.
16. Klein, G., 1994. Epstein-Barr virus strategy in normal and neoplastic B-cells. Cell 77, 791-793.
17. Luka, J., Kreofsky, T., Person, G.R., Hennessy, K., Kieff, E., 1984. Identification and characterization of a cellular protein that cross reacts with the Epstein-Barr virus nuclear antigen. J. Virol. 52, 833-838.
18. Menezes, J., Leibold, W., Klein, G., Clements, G., 1975. Establishment and characterization of an Epstein-Barr virus (EBV)-negative lymphonlastoid B-cell line (BJAB) from an exceptional EBV-genome-negative African Burkitt's lymphoma. Biomedicine 22, 276-284.
19. Miller, G., Robinson, J., Heston, L., Lipman, M., 1974. Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference. Proc. Natl. Acad. Sci. USA 71, 4006-4010.
20. Millman, G., Scott, A.L., Cho, S., Hartman, S.C., Ades, D.K., Hayward, G.S., Ki, P.G., August, J.T., Hayward, S.D., 1985. Carboxyl-terminal domain of the Epstein-Barr virus nuclear antigen 1 is highly immunogenic in man. Proc. Natl. Acad. Sci. USA 82, 6300-6304.
21. Pulvertraft, R.J.V., 1965. A study of malignant tumors in Nigeria by short-term tissue culture. J. Clin. Pathol. 18, 261-273.
22. Rickinson, A.B., Kieff, E. 1996. Epstein-Barr Virus. In: Fields, B.N. (Ed.), Virology, 3rd edn., Lippincott-Racen, Philadelphia, pp. 2397-2446.
23. Sculley, T.B., Splesberg, T.C., Pearson, G.R., 1984. Characterization of Epstein-Barr Virus nuclear antigen(s) in different cell lines by radioimmunoelectrophoresis. Intervirology 22, 191-200.
24. Shah, W.A., Ambinder, R.F., Hayward, G.S., Hayward, S.D., 1992. Binding of EBNA-1 to DNA creates a protease resistant domain that encompasses the DNA recognition and dimerization functions. J. Virol. 66.
25. Snudden, D.K., Smith, P.R., Lai, D., Ng, M-H., Griffin, B.E., 1995. Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumors. Oncogene 10, 1545-1552.
26. Sternas, L., Middleton, T., Sugden, B., 1990. The average number of molecules of Epstein-Barr nuclear antigen 1 per cell does not correlate with the average number of Epstein-Barr virus (Epstein-Barr virus) DNA molecules per cell among different clones of Epstein-Barr virus-immortalized cells. J. Virol. 64, 2407-2410.
27. van Santen, V., Cheung, A., Kieff, E., 1981. Epstein-Barr virus (Epstein-Barr virus) RNA. Vll. Viral cytoplasmic RNA in a restringently infected cell line transformed in vitro by Epstein-Barr virus. Proc. Natl. Acad. Sci. USA 78, 1930-1934.
28. Wrightham, M.N., Stewart, J.P., Janjua, N.J., Pepper, S.V., Sample, C., Rooney, C.M., Arrand, J.R., 1995. Antigenic and sequence variation in the C-terminal unique domain of the Epstein-Barr virus nuclear antigen EBNA-1. Virology 208, 521-530.
29. Wilson, J.B., Bell, J.L., Levine, A.J., 1996. Expression of Epstein-Barr virus nuclear antigen-1 induces B-cell neoplasma in transgenic mice. EMBO J. 15, 3117-3126.
30. Yates, J.L., Warren, N., Sudgen, B., 1985. Stable replication of plasmid derived from Epstein-Barr virus in various mammalian cells. Nature (London) 313, 812-815.