Central control mechanisms in hypertension

Australian and New Zealand Journal of Medicine

Volumn 27, Issue 4, 1997, Pages 474-478

  Arnolda, Leonard ^a,b   Wang, Hui H ^a   Maison, Jane ^b   Llewellyn Smith, Ida ^a   Suzuki, Satoshi ^b   Pilovosky, Paul ^b   Chalmers, John ^a  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Antisense oligonucleotides; Human hypertension; Spontaneously hypertensive rat; Sympathetic nervous system

Indexed keywords

ANIMAL MODEL; BLOOD PRESSURE REGULATION; CONFERENCE PAPER; GENE EXPRESSION REGULATION; HYPERTENSION; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC TONE;

EID: 0030826260     PISSN: 00048291     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1445-5994.1997.tb02221.x     Document Type: Conference Paper

References (41)

1. Dittmar C. Über die läge des sogenannten Gefasszentrums in der Medulla oblongata. Ber Verh sachs Ges Wiss Leipzig Math Phys Kl 1873; 25: 449-69.
2. Starling EH. The physiological factors in hyperpyesia. BrMedJ 1925; 2: 1163-5.
3. Esler MD. Catecholamines and essential hypertension. Baillieres Clin-Endocrinol Metab 1993; 7: 415-38.
4. Floras JS, Hara K. Sympathoneural and haemodynamic characteristics of young subjects with mild essential hypertension. J Hypertens 1993; 11: 647-55.
5. Lowenstein J. Clonidine. Ann Intern Med 1980; 92: 74-7.
6. Doyle AE, Smirk FH. The neurogenic component in hypertension. Circulation 1955; 12: 543-52.
7. Prichard BNS, Gillam PMS. Use of propranolol (inderal) in the treatment of hypertension. Br Med J 1964; 2: 725-7.
8. Chalmers J, Arnolda L, Llewellyn-Smith I, Minson J, Pilowsky P. Central nervous control of blood pressure. In: Swales J (Ed.). Textbook of Hypertension. Oxford: Blackwell Scientific Publications Ltd, 1994; 409-26.
9. Dampney RAL. Functional organisation of central pathways regulating the cardiovascular system. Physiol Rev 1994; 74: 323-64.
10. Llewellyn-Smith IJ, Minson JB, Pilowsky PM, Arnolda LF, Chalmers JP. The one hundred percent hypothesis: glutamate or GABA in synapses on sympathetic preganglionic neurons. Clin Exp Hypertens 1995; 17: 323-33.
11. Bacon S, Smith AD. Preganglionic sympathetic neurones innervating the rat adrenal medulla: immunocytochemical evidence of synaptic input from nerve terminals containing substance P, GABA or 5hydroxytryptamine. J Auton Nerv Syst 1988; 24: 97-122.
12. Ross ÇA, Ruggiero DA, Park DH et al. Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing Cl adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressin. J Neurosci 1984; 4: 474-94.
13. Sved AF. Effects of monoamine oxidase inhibition on catecholamine levels: evidence of synthesis but not storage of epinephrine in rat spinal cord. Brain Res 1990; 512: 253-8.
14. AicCall RB. Effects of putative neurotransmitters on sympathetic preganglionic neurons. Annu Rev Physiol 1988; 50: 553-64.
15. Mills EH, Minson JB, Chalmers J. Effects of intrathecal administration of methysergide, phentolamine and pindolol on presser responses to electrical stimulation of the rostral ventrolateral medulla. J Cardiovasc Pharmacol 1988; 11: 456-60.
16. Minson J, Pilowsky P, Llewellyn-Smith I, Kaneko T, Kapoor V, Chalmers J. Glutamate in spinally projecting neurons of the rostral ventral medulla. Brain Res 1991; 555: 326-31.
17. Kapoor V, Minson JB, Chalmers J. Ventral medulla stimulation increases blood pressure and spinal cord amino acid release. Neuro Report 1992; 3: 55-8.
18. Mills EH, Minson JB, Pilowsky PM, Chalmers J. Nmethyl-D-aspartate receptors in the spinal cord mediate pressor responses to stimulation of the rostral ventrolateral medulla in the rat. Clin Exp Pharmacol Physiol 1988; 15: 147-55.
19. Bazil MK, Gordon FJ. Spinal NMDA receptors mediate pressor responses evoked from the rostral ventrolateral medulla. Am J Physiol 1991; 260: H267H275.
20. Alexander RS. Tonic and reflex functions of medullary sympathetic cardiovascular centres. J Neurophysiol 1946; 9: 205-17.
21. Day TA, Ro A, Renaud LP. Depressor area within the caudal ventrolateral medulla does not correspond to the Al catecholaminergic cell group. Brain Res 1983; 279: 299-302.
22. Blessing JVw. Depressor neurones in rabbit medulla act via GABA receptors in rostral medulla. Am J Physiol 1988; 254: H686-H692.
23. Blessing JVW, YC'est MJ, Chalmers JP. Hypertension, bradycardia and pulmonary oedema in the conscious rabbit after lesions of the ventrolateral medulla oblongata coinciding with the Al group of catecholamine neurons. Circulation Res 1981; 49: 949-58.
24. West MJ. Blessing JVW, Chalmers JP. Arterial baroreceptor reflex function in the conscious rabbit after lesions in the ventrolateral medulla oblongata coinciding with the Al group of catecholamine neurons. Circulation Res 1981; 49: 959-70.
25. Lipski J, McAllen RM, Spyer KM. The sinus nerve and baroreceptor input into the medulla of the cat. J Physiol 1975; 269: 797-810.
26. Talman WT, Pcrrone MH, Reis DJ. Evidence for Lglutamate as the neurotransmitter of primary baroreceptor afferent nerve fibers. Science 1980; 209: 813-5.
27. Gordon FJ. Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal ventrolateral medulla. Am J Physiol 1987; 252: R628-R633.
28. Somogyi P, Minson JB, Morilak D, Llewellyn-Smith I, Mcllhinney JRA, Chalmers JP. Evidence for an excitatory amino acid pathway in the brainstem and for its involvement in cardiovascular control. Brain Res 1989; 496: 401-7.
29. Grobecker H, Roizen MF, Weise V, Saavedra JM, Kopin IJ. Sympathoadrenal medullary activity in young, spontaneously hypertensive rats. Nature 1975; 258: 267.
30. Judy JW, Watanabe AM, Henry DP, Besch HR Jr, Murphy JVR, Hockel G. Sympathetic nerve activity. Role in the regulation of blood pressure in the spontaneously hypertensive rat. Circulation Res 1976; 38: II-21-H-29.
31. Rickstein S-E, Lundin S, Thoren P. Spontaneous variations in arterial blood pressure, heart rate and sympathetic nerve activity in conscious normotensive and spontaneously hypertensive rats. Acta Physiol Scand 1984; 120: 595-600.
32. Leenen FHH, Yuan B, Tsoporis J, Lee RMKW. Arterial hypertrophy and presser responsiveness during development of hypertension in spontaneously hypertensive rats. J Hypertens 1994; 12: 23-32.
33. Mills E, Minson J, Drolet G, Chalmers J. Effect of intrathecal amino acid receptor antagonists on basal blood pressure and presser responses to brainstem stimulation in normotensive and hypertensive rats. J Cardiovasc Pharmacol 1990; 15: 877-83.
34. Minson J, Arnolda L, Llewellyn-Smith I, Pilowsky P, Chalmers J. Altered c-fos in rostral ventral medulla and spinal cord of spontaneously hypertensive rats. Hypertension 1996; 27: 433-41.
35. Chan RKw, Chan YS, Wong TM. Electrophysiological properties of neurons in the rostral ventrolateral medulla of normotensive and spontaneously hypertensive rats. Brain Res 1991; 549: 118-26.
36. Smith JK, Barron KW. GABAergic responses in ventrolateral medulla in spontaneously hypertensive rats. Am J Physiol 1990; 258: R450-R456.
37. Arnolda L, Minson J, Pilowsky P, Llewellyn-Smith I, Chalmers J. Decreased activity of a medullary GABA pathway contributes to hypertension in the spontaneously hypertensive rat. High Blood Pressure 1995; 4: 97-104.
38. Murotani H, Ferrario CM, Averill DB. Ventrolateral medulla in spontaneously hypertensive rats: role of angiotensin II. Am J Physiol 1993; 264: R388-R395.
39. Minson J, Denoroy L, Chalmers J. Effects of sinoaortic baroreceptor denervation on blood pressure and PNMT activity in medulla oblongata and spinal cord of normotensive and genetically hypertensive rats. J Hypertens 1985; 3: 81-7.
40. Wang H, Arnolda LF, Minson JB, Pilowsky PM, Llewellyn-Smith IJ, Chalmers JP. Disinhibition of bulbospinal sympathetic excitatory pathway contributes to hypertension in conscious SHR. Proc High Blood Pressure Research Council of Australia, 15th Meeting, 1995; 104.
41. Suzuki S, Pilowsky P, Minson J, Arnolda L, Llewellyn-Smith I, Chalmers J. Antisense to thyrotropin releasing hormone receptor reduces arterial blood pressure in spontaneously hypertensive rats. Circ Res 1995; 77: 679-83.