SCOPUS 정보 검색 플랫폼

Volumn 32, Issue 10, 1997, Pages 805-814

Structure-activity relationship studies on (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: Variation of the alkanoic acid substituent, the acyl chain and the position of the pyrrole nitrogen

(1) Lehr, M a

a UNIVERSITY OF MUNICH (Germany)

Author keywords

(4 acylpyrrol 2 yl)alkanoic acid; Cytosolic phospholipase A2; Inhibitor; Structure activity relationship

Indexed keywords

1,3,5 TRIMETHYL 4 OCTADECANOYLPYRROL 2 YL)ACETIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARACHIDONIC ACID METABOLISM; ARTICLE; ASTHMA; CATTLE; CYTOLYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; INFLAMMATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGLUTINATION;

EID: 0030826057 PISSN: 02235234 EISSN: None Source Type: Journal
DOI: 10.1016/S0223-5234(99)80066-X Document Type: Article

Times cited : (15)

References (48)

1
- 0023764723
- Moncada S, Higgs EA (1988) Ann New York Acad Sci 522, 454-463
- (1988) Ann New York Acad Sci , vol.522 , pp. 454-463
- Moncada, S.¹ Higgs, E.A.²

2
- 0023177955
- Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN (1991) Science 237, 1171-1176
- (1991) Science , vol.237 , pp. 1171-1176
- Samuelsson, B.¹ Dahlen, S.E.² Lindgren, J.A.³ Rouzer, C.A.⁴ Serhan, C.N.⁵

3
- 0026611698
- Moreno JJ, Ferrer X, Ortega E, Carganico G (1992) Agents Actions 32, 258-263
- (1992) Agents Actions , vol.32 , pp. 258-263
- Moreno, J.J.¹ Ferrer, X.² Ortega, E.³ Carganico, G.⁴

4
- 0027283342
- Venable ME, Zimmerman GA, McIntyre TM, Prescott SM (1993) J Lipid Res 34, 691-702
- (1993) J Lipid Res , vol.34 , pp. 691-702
- Venable, M.E.¹ Zimmerman, G.A.² McIntyre, T.M.³ Prescott, S.M.⁴

5
- 0024588250
- Hara S, Kudo I, Chang HW, Matsuta K (1989) J Biochem 105, 395-399
- (1989) J Biochem , vol.105 , pp. 395-399
- Hara, S.¹ Kudo, I.² Chang, H.W.³ Matsuta, K.⁴

6
- 0026489529
- Gronroos JM, Nevalainen TJ (1992) Digestion 52, 232-236
- (1992) Digestion , vol.52 , pp. 232-236
- Gronroos, J.M.¹ Nevalainen, T.J.²

7
- 0025917869
- Green JA, Smith GM, Buchta R, Lee R, Ho KY, Rajkovic IA, Scott KF (1991) Inflammation 15, 355-367
- (1991) Inflammation , vol.15 , pp. 355-367
- Green, J.A.¹ Smith, G.M.² Buchta, R.³ Lee, R.⁴ Ho, K.Y.⁵ Rajkovic, I.A.⁶ Scott, K.F.⁷

8
- 0028970917
- Murakami M, Kudo I, Inoue K (1995) J Lipid Mediators Cell Signalling 12, 119-130
- (1995) J Lipid Mediators Cell Signalling , vol.12 , pp. 119-130
- Murakami, M.¹ Kudo, I.² Inoue, K.³

9
- 12644258541
- Dillard RD, Bach NJ, Draheim SE, Berry DR, Carlson DG, Chirgadze NY, Clawson DK, Hartley LW, Johnson LM, Jones ND, McKinney ER, Mihelich ED, Olkowski JL, Schevitz RW, Smith AC, Snyder DW, Sommers CD, Wery JP (1996) J Med Chem 39, 5119-5175
- (1996) J Med Chem , vol.39 , pp. 5119-5175
- Dillard, R.D.¹ Bach, N.J.² Draheim, S.E.³ Berry, D.R.⁴ Carlson, D.G.⁵ Chirgadze, N.Y.⁶ Clawson, D.K.⁷ Hartley, L.W.⁸ Johnson, L.M.⁹ Jones, N.D.¹⁰ McKinney, E.R.¹¹ Mihelich, E.D.¹² Olkowski, J.L.¹³ Schevitz, R.W.¹⁴ Smith, A.C.¹⁵ Snyder, D.W.¹⁶ Sommers, C.D.¹⁷ Wery, J.P.¹⁸

10
- 0030300104
- Teshirogi I, Matsutani S, Shirahase K, Fujii Y, Yoshida T, Tanaka K, Ohtani M (1996) J Med Chem 39, 5183-5191
- (1996) J Med Chem , vol.39 , pp. 5183-5191
- Teshirogi, I.¹ Matsutani, S.² Shirahase, K.³ Fujii, Y.⁴ Yoshida, T.⁵ Tanaka, K.⁶ Ohtani, M.⁷

11
- 0029067997
- Tibes U, Vondran A, Rodewald E, Friebe WG, Schäfer W, Scheuer W (1995) Int Arch Allergy Immunol 107, 432-434
- (1995) Int Arch Allergy Immunol , vol.107 , pp. 432-434
- Tibes, U.¹ Vondran, A.² Rodewald, E.³ Friebe, W.G.⁴ Schäfer, W.⁵ Scheuer, W.⁶

12
- 0343631281
- Tibes U, Scheuer W, Burgermeister E, Thierse HJ, Friebe WG (1996) Prostaglandins, Leukotrienes and Essential Fatty Acids 55 (Suppl 1), 95
- (1996) Prostaglandins, Leukotrienes and Essential Fatty Acids , vol.55 , Issue.SUPPL. 1 , pp. 95
- Tibes, U.¹ Scheuer, W.² Burgermeister, E.³ Thierse, H.J.⁴ Friebe, W.G.⁵

13
- 0030592136
- Fox N, Song M, Schrementi J, Sharp JD, White DL, Snyder DW, Hartley LW, Carlson DG, Bach NJ, Dillard RD, Draheim SE, Bobbitt JL, Fisher L, Mihelich ED (1996) Eur J Pharmacol 308, 195-203
- (1996) Eur J Pharmacol , vol.308 , pp. 195-203
- Fox, N.¹ Song, M.² Schrementi, J.³ Sharp, J.D.⁴ White, D.L.⁵ Snyder, D.W.⁶ Hartley, L.W.⁷ Carlson, D.G.⁸ Bach, N.J.⁹ Dillard, R.D.¹⁰ Draheim, S.E.¹¹ Bobbitt, J.L.¹² Fisher, L.¹³ Mihelich, E.D.¹⁴

14
- 0025107548
- Clark JD, Milona N, Knopf JL (1990) Proc Natl Acad Sci USA 87, 7708-7712
- (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7708-7712
- Clark, J.D.¹ Milona, N.² Knopf, J.L.³

15
- 0025133135
- Gronich JH, Bonventre JV, Nemonoff RA (1990) Biochem J 271, 37-43
- (1990) Biochem J , vol.271 , pp. 37-43
- Gronich, J.H.¹ Bonventre, J.V.² Nemonoff, R.A.³

16
- 0025922172
- Kramer RM, Roberts EF, Manetta J, Putnam JE (1991) J Biol Chem 266, 5268-5272
- (1991) J Biol Chem , vol.266 , pp. 5268-5272
- Kramer, R.M.¹ Roberts, E.F.² Manetta, J.³ Putnam, J.E.⁴

17
- 0026354921
- Wijkander J, Sundler R (1991) Eur J Biochem 202, 873-880
- (1991) Eur J Biochem , vol.202 , pp. 873-880
- Wijkander, J.¹ Sundler, R.²

18
- 0029985923
- Roshak A, Mochan E, Marshall LA (1996) J Rheumatol 23, 420-427
- (1996) J Rheumatol , vol.23 , pp. 420-427
- Roshak, A.¹ Mochan, E.² Marshall, L.A.³

19
- 0026611170
- Lin LL, Lin AY, Knopf JL (1992) Proc Natl Acad Sci USA 89, 6147-6151
- (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6147-6151
- Lin, L.L.¹ Lin, A.Y.² Knopf, J.L.³

20
- 0027337227
- Mounier C, Faili A, Vargaftig BB, Bon C, Hatmi M (1993) Eur J Biochem 16, 169-175
- (1993) Eur J Biochem , vol.16 , pp. 169-175
- Mounier, C.¹ Faili, A.² Vargaftig, B.B.³ Bon, C.⁴ Hatmi, M.⁵

21
- 0028024212
- Mounier C, Vargaftig BB, Franken PA, Verheij HM, Bon C, Touqui L (1994) Biochim Biophys Acta 1214, 88-96
- (1994) Biochim Biophys Acta , vol.1214 , pp. 88-96
- Mounier, C.¹ Vargaftig, B.B.² Franken, P.A.³ Verheij, H.M.⁴ Bon, C.⁵ Touqui, L.⁶

22
- 0028016212
- Faili A, Emadi S, Vargaftig B, Hatmi M (1994) British J Haematol 88, 149-155
- (1994) British J Haematol , vol.88 , pp. 149-155
- Faili, A.¹ Emadi, S.² Vargaftig, B.³ Hatmi, M.⁴

23
- 0028173131
- Angel J, Berenbaum F, Le Denmat C, Nevalainen T, Masliah J, Fournier C (1994) Eur J Biochem 226, 125-131
- (1994) Eur J Biochem , vol.226 , pp. 125-131
- Angel, J.¹ Berenbaum, F.² Le Denmat, C.³ Nevalainen, T.⁴ Masliah, J.⁵ Fournier, C.⁶

24
- 0028181780
- Hulkower KI, Wertheimer SJ, Levin W, Coffey JW, Anderson CM, Chen T, DeWitt DL, Crowl RM, Hope WC, Morgan DW (1994) Arthritis Rheumatism 37, 653-661
- (1994) Arthritis Rheumatism , vol.37 , pp. 653-661
- Hulkower, K.I.¹ Wertheimer, S.J.² Levin, W.³ Coffey, J.W.⁴ Anderson, C.M.⁵ Chen, T.⁶ DeWitt, D.L.⁷ Crowl, R.M.⁸ Hope, W.C.⁹ Morgan, D.W.¹⁰

25
- 0027360798
- Connolly S, Robinson DH (1993) Drug News Perspectives 6, 584-590
- (1993) Drug News Perspectives , vol.6 , pp. 584-590
- Connolly, S.¹ Robinson, D.H.²

26
- 0028970907
- Clark JD, Schievella AR, Nalefski EA, Lin LL (1995) J Lipid Mediators Cell Signalling 12, 83-117
- (1995) J Lipid Mediators Cell Signalling , vol.12 , pp. 83-117
- Clark, J.D.¹ Schievella, A.R.² Nalefski, E.A.³ Lin, L.L.⁴

27
- 0027513175
- Mayer RJ, Marshall LA (1993) FASEB J 7, 339-348
- (1993) FASEB J , vol.7 , pp. 339-348
- Mayer, R.J.¹ Marshall, L.A.²

28
- 0343195583
- McGregor WH, Chang JY (1988) PCT Int Appl WO 88 06,885
- (1988) PCT Int Appl WO 88 06,885
- McGregor, W.H.¹ Chang, J.Y.²

29
- 0025147986
- 2 activity in vitro and in vivo
- (Wong PYK, Dennis EA, eds) Plenum Press, New York, London
- 2: Role and Function in Inflammation, Vol 275 (Wong PYK, Dennis EA, eds) Plenum Press, New York, London, 169-182
- (1990) 2: Role and Function in Inflammation , vol.275 , pp. 169-182
- Marshall, L.A.¹ Chang, J.Y.²

30
- 0027205399
- Märki F, Breitenstein W, Beriger E, Bernasconi R, Caravatti G, Francis JE, Paioni R, Wehrli HU, Wiederkehr R (1993) Agents Actions 38, 202-211
- (1993) Agents Actions , vol.38 , pp. 202-211
- Märki, F.¹ Breitenstein, W.² Beriger, E.³ Bernasconi, R.⁴ Caravatti, G.⁵ Francis, J.E.⁶ Paioni, R.⁷ Wehrli, H.U.⁸ Wiederkehr, R.⁹

31
- 0027131849
- Trimble LA, Street IP, Perrier H, Tremblay NM, Weech PK, Bernstein MA (1993) Biochemistry 32, 12560-12565
- (1993) Biochemistry , vol.32 , pp. 12560-12565
- Trimble, L.A.¹ Street, I.P.² Perrier, H.³ Tremblay, N.M.⁴ Weech, P.K.⁵ Bernstein, M.A.⁶

32
- 0343631257
- Clemens JA, Sofia MJ, Stephenson DT (1995) PCT Int Appl WO 95 17,183
- (1995) PCT Int Appl WO 95 17,183
- Clemens, J.A.¹ Sofia, M.J.² Stephenson, D.T.³

33
- 0029729794
- Lehr M (1996) Arch Pharm Pharm Med Chem 329, 483-488
- (1996) Arch Pharm Pharm Med Chem , vol.329 , pp. 483-488
- Lehr, M.¹

34
- 85030303115
- PhD Thesis, University of Regensburg (Germany)
- Lehr M (1989) PhD Thesis, University of Regensburg (Germany)
- (1989)
- Lehr, M.¹

35
- 0023819724
- Dannhardt G, Lehr M (1988) Arch Pharm 321, 159-162
- (1988) , vol.321 , pp. 159-162
- Dannhardt, G.¹ Lehr, M.²

36
- 84931653447
- Mironov AF, Ol'shanskaya NB, Zhestkov VP, Evstigneeva RP (1973) Khim Geterotsikl Soedin 27-30
- (1973) Khim Geterotsikl Soedin , pp. 27-30
- Mironov, A.F.¹ Ol'shanskaya, N.B.² Zhestkov, V.P.³ Evstigneeva, R.P.⁴

37
- 85178473029
- Nenitzescu CD, Solomonica E (1931) Ber Dtsch Chem Ges 64, 1924-1931
- (1931) Ber Dtsch Chem Ges , vol.64 , pp. 1924-1931
- Nenitzescu, C.D.¹ Solomonica, E.²

38
- 0343195566
- Fischer H, Walach B (1926) Liebigs Ann Chem 447, 38-48
- (1926) Liebigs Ann Chem , vol.447 , pp. 38-48
- Fischer, H.¹ Walach, B.²

39
- 0018392187
- Bates HA, Rapoport H (1979) J Am Chem Soc 101, 1259-1265
- (1979) J Am Chem Soc , vol.101 , pp. 1259-1265
- Bates, H.A.¹ Rapoport, H.²

40
- 0002141061
- Robinson JA, McDonald E, Battersby AR (1985) J Chem Soc Perkin Trans I 1699-1709
- (1985) J Chem Soc Perkin Trans I , pp. 1699-1709
- Robinson, J.A.¹ McDonald, E.² Battersby, A.R.³

41
- 84982078113
- Treibs A, Dietl A (1958) Liebigs Ann Chem 619, 80-95
- (1958) Liebigs Ann Chem , vol.619 , pp. 80-95
- Treibs, A.¹ Dietl, A.²

42
- 0342898510
- Treibs A, Michl KH (1954) Liebigs Ann Chem 589, 163-173
- (1954) Liebigs Ann Chem , vol.589 , pp. 163-173
- Treibs, A.¹ Michl, K.H.²

43
- 0000627966
- Lehr M (1992) Pharm Pharmacol Lett 2, 176-179
- (1992) Pharm Pharmacol Lett , vol.2 , pp. 176-179
- Lehr, M.¹

44
- 0028272107
- Riendeau D, Guay J, Weech PK, Laliberte F, Yergey J, Li C, Desmarais S, Perrier H, Liu S, Nicoll-Griffith D, Street IP (1994) J Biol Chem 269, 15619-15624
- (1994) J Biol Chem , vol.269 , pp. 15619-15624
- Riendeau, D.¹ Guay, J.² Weech, P.K.³ Laliberte, F.⁴ Yergey, J.⁵ Li, C.⁶ Desmarais, S.⁷ Perrier, H.⁸ Liu, S.⁹ Nicoll-Griffith, D.¹⁰ Street, I.P.¹¹

45
- 0000918726
- Lehr M (1995) Pharm Pharmacol Lett 5, 108-111
- (1995) Pharm Pharmacol Lett , vol.5 , pp. 108-111
- Lehr, M.¹

46
- 0029661860
- Lehr M (1996) Arch Pharm Pharm Med Chem 329, 386-392
- (1996) Arch Pharm Pharm Med Chem , vol.329 , pp. 386-392
- Lehr, M.¹

47
- 37049092546
- Baldwin JE, Bottaro JC (1982) J Chem Soc Chem Commun 624-625
- (1982) J Chem Soc Chem Commun , pp. 624-625
- Baldwin, J.E.¹ Bottaro, J.C.²

48
- 0342760967
- Hess K, Wissing F, Suchier A (1915) Ber Dtsch Chem Ges 48, 1865-1884
- (1915) Ber Dtsch Chem Ges , vol.48 , pp. 1865-1884
- Hess, K.¹ Wissing, F.² Suchier, A.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.