Pharmacokinetics and metabolism of the new thromboxane a2 receptor antagonist ramatroban in animals. 2nd communication: Distribution to organs and tissues in male, female and pregnant rats, and characteristics of protein binding in plasma

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 8, 1997, Pages 939-948

  Steinke, Wolfram ^a   Ahr, Hans Jürgen ^a   Hirayama, Masashi ^b  

^a BAYER AG   (Germany)

^b BAYER YAKUHIN LTD   (Japan)

Author keywords

BAY u 3405; CAS 116649 85 5; Elimination; Mammary excretion; Plantal transfer; Plasma protein binding; Ramatroban; Thromboxane A2 receptor antagonist; Tissue distribution

Indexed keywords

RAMATROBAN; THROMBOXANE A2 RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; FEMALE; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PLACENTAL TRANSFER; PREGNANCY;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; AUTORADIOGRAPHY; BLOOD PROTEINS; CARBAZOLES; DOGS; FEMALE; INJECTIONS, INTRAVENOUS; MALE; MICE; MILK; PLACENTA; PREGNANCY; PROTEIN BINDING; RABBITS; RATS; RATS, WISTAR; RECEPTORS, THROMBOXANE; SULFONAMIDES; THROMBOXANE A2; TISSUE DISTRIBUTION;

EID: 0030825494     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. McKenniff, M. G:, Norman, P., Cuthbert, N. J. et al., Br. J Pharmacol. 104, 585 (1991)
2. Theis, J. G. W., Dellweg, H., Perzborn, E. et al., Biochem. Pharmacol. 44, 495 (1992)
3. Narita, S., Asakura, K., Kataura, A., Int. Arch. Allergy Immunol. 109, 161 (1996)
4. Iwamoto, I., Umibe, T., Nakajima, H. et al., Int. Arch. Allergy Immunol. 108, 68 (1995)
5. Inoue, H., Tani, N., Iijima, H. et al., Arerugi 42, 205 (1993)
6. Nagai, H., Takeda, H., Yamaguchi, S. et al., Prostaglandins 50, 75 (1995)
7. Radtke, M., Boberg, M., Pleiss, U. et al., J. Labelled Comp. Radiopharm., 34 (12), 1207 (1994)
8. Curtis, C. G., Gross, S. A. M., McCulloch, R. J. et al., in: Whole body autoradiography, J. E. Treherne, P. H. Rubery (eds.), Academic Press, London-New York (1981)
9. Hebel, R., Stromberg, M. W., in: anantomy and embryology of the laboratory rat, Bio-Med Verlag, Wörthsee, Germany (1986)
10. Heintze, J., Fischbeck, H., Z. Phys. 147, 277 (1957)
11. Benet, L. Z., Galeazzi, R. L., J. Pharm. Sci. 68, 1071 (1979)
12. Yamaoka, K., Nakagawa, T., Uno, T., J. Pharmacokin. Biopharm. 6, 547 (1978)
13. Riegelman, S., Collier, P., J. Pharmacokin. Biopharm. 8, 509 (1980)
14. Allen, L., Kimura, K., McKichan, J. et al., J. Clin. Pharmacol. 22, 1S (1982)
15. Boberg, M., Ahr, J. J., Beckermann, B. et al., Arzneim.-Forsch./Drug Res. 47 (II), 928 (1997)
16. Waddell, W. J., Marlowe, C., Pharmacol. Ther. 14, 375 (1981)
17. Grigor, M. R., Allan, J. F., Carrington, J. M. et al., J. Nutrition 7, 1247 (1987)