BRS1, a C30 bis-amino, bis-hydroxy polyunsaturated lipid from an australian calcareous sponge that inhibits protein kinase C

Toxicon

Volumn 35, Issue 7, 1997, Pages 1125-1129

  Willis, R H ^a   De Vries, D J ^a,b  

^a AUSTRALIAN INSTITUTE OF MARINE SCIENCE   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL ESTER; POLYUNSATURATED FATTY ACID; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR;

ARTICLE; AUSTRALIA; BINDING SITE; ENZYME INHIBITION; LIPID ANALYSIS; PRIORITY JOURNAL; SPECTROSCOPY; SPONGE;

AMINO ALCOHOLS; ANIMALS; AUSTRALIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FATTY ALCOHOLS; PHORBOL 12,13-DIBUTYRATE; PORIFERA; PROTEIN KINASE C; RADIOLIGAND ASSAY; RATS;

CALCAREA;

EID: 0030825377     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(96)00218-8     Document Type: Article

References (15)

1. de Vries, D. J., Herald, C. L., Pettit, G. R. and Blumberg, P. M. (1988) Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain. Biochem. Pharmac. 37, 4069-1073.
2. de Vries, D. J., Sundar Rao, K. and Willis, R. H. (1997) Application of a radioreceptor assay to the screening and characterisation of compounds from marine organisms with activity at the phorbol ester binding site of protein kinase C. Toxicon 35, 347-354.
3. Fujiki, H., Suganuma, M. and Sugimura, T. (1989) Significance of new environmental tumor promoters. J. envir. Sci. Hlth C7, 1-51.
4. Kong, F. and Faulkner, D. J. (1993) Leucettamols A and B, two antimicrobial lipids from the calcareous sponge Leucetta microaphis. J. org. Chem. 58, 970-971.
5. Jares-Erijman, E. A., Bapat, C. P., Lithgow-Bertelloni, A., Rinehart, K. L. and Sakai, R. (1993) Crucigasterins, new polyunsaturated amino alcohols from the Mediterranean tunicate Pseudistoma crucigaster. J. org. Chem. 58, 5732-5737.
6. Makerieva, T. N., Denisenko, V. A., Stonik, V. A., Milgrom. Yu. M. and Rashkes, Ya. V. (1989) Rhizochalin, a novel secondary metabolite of mixed biosynthesis from the sponge Rhizochalina incrustata. Tetrahedron Lett. 30, 6581-6584.
7. Newton, A. C. (1995) Protein kinase C: structure, function and regulation. J. biol. Chem. 270, 28495-28498.
8. Nishizuka, Y. (1992) Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
9. Pettit, G. R., Herald. C. L., Doubek, D. L., Herald, D. L., Arnold, E. and Clardy, J. (1982) Isolation and structure of bryostatin 1. J. Am. chem. Soc. 104, 6846-6848.
10. Silverstein, R. M., Bassler, G. C. and Morrill, T. C. (1991) Spectrometric Identification of Organic Compounds, 5th Edn. New York: Wiley.
11. S. J., Ho, C., Kelly, M. B., Larkin, J. D., Taddeo, F. J., Yeager, M. D. and Christopher, C. D. (1996) Protein kinase Ca contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities. J. biol. Chem. 271, 4627-4631.
12. Stabel, S. and Parker. P. J. (1991) Protein kinase C. Pharmac. Ther. 51, 71-95.
13. Sullivan, J. P., Connor, J. R., Shearer, B. G. and Burch, R. M. (1992) 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Molec. Pharmac. 41, 38-44.
14. Tamaoki, T. and Nakano, H. (1990) Potent and specific inhibitors of protein kinase C of microbial origin. BioTechnology 8, 732-735.
15. Wilkinson, S. E. and Hallam, T. J. (1994) Protein kinase C: is its pivotal role in cellular activation over-stated? Trends biochem. Sci. 15, 53-57.