Intraventricular administration of GABA(A) receptor agonist muscimol attenuates the exo-focal change of the substantia nigra neurons following transient middle cerebral artery occlusion in rats

Neuropathology

Volumn 17, Issue 2, 1997, Pages 101-105

  Yamada, Kazumichi ^a   Goto, Satoshi ^a   Yoshikawa, Makoto ^a   Okamura, Akira ^a   Nagahiro, Shinji ^a   Ushio, Yukitaka ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Exo focal post ischemic death; Heat shock response; Immunohistochemistry; Middle cerebral artery occlusion; Substantia nigra; aminobutyric acid

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; HEAT SHOCK PROTEIN; MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; ARTICLE; BRAIN ISCHEMIA; CELL DENSITY; CELL LOSS; CONTROLLED STUDY; HEAT SHOCK RESPONSE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

EID: 0030824918     PISSN: 09196544     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1789.1997.tb00021.x     Document Type: Article

References (13)

1. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 1982; 239: 57-69.
2. Kirino T, Sano K. Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol. (Berl.) 1984; 62:201-208.
3. Nakano S, Kogure K, Fujikura H. Ischemia-induced slowly progressive neuronal damage in the rat brain. Neuroscience 1990;38:115-124.
4. Smith ML, Auer RN, Siesjö BK. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol. 1984; 64:309-332.
5. Globus MY-T, Busto R, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia. Neurosci. Lett. 1988; 91: 36-40.
6. Globus MY-T, Ginsberg MD, Busto R. Excitotoxic index: a biochemical marker of selective vulnerability. Neurosci. Lett. 1991; 127: 39-42.
7. Kato H, Araki T, Kogure K. Role of the excitotoxic mechanism in the development of neuronal damage following repeated brief cerebral ischemia in the gerbil: Protective effects of MK-801 and pentobarbital. Brain Res. 1990:516:175-179.
8. Meldrum B. Excitotoxicity in ischemia: an overview. In: Ginsberg MD, Dietrich WD (eds.) Cerebrovascular Diseases - Sixteenth Research (Princeton) Conference New York: Raven Press, 1989; 47-60.
9. Rothman SM, Olney JW. Excitotoxicity and the NMDA receptor. Trends Neurosci. 1987; 10: 299-302.
10. Nagasawa H, Kogure K. Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 1989; 20: 1037-1043.
11. Nagasawa H, Kogure K. Exo-focal postischemic neuronal death in the rat brain. Brain Res. 1990; 524:196-202.
12. Tamura A, Kirino T, Sano K, Takagi K, Oka H. Atrophy of the ipsilateral substantia nigra following middle cerebral artery occlusion in the rat. Brain Res. 1990; 510: 154-157.
13. Tamura A, Nakayama H, Kirino T, Tomukai N, Sano K, Kanazawa I. Remote disinhibition hyperemia after focal cerebral ischemia. In: Tomita M, Sawada T, Noritomi H, Heiss WD (eds) Cerebral Hyperemia and Ischemia: From the Standpoint of Cerebral Blood Volume. Amsterdam: Elsevier, 1988; 195-206.