A newly synthesized bifunctional inhibitor, CKA1083, enhances adriamycin activity against human ovarian carcinoma cells

Anticancer Research

Volumn 17, Issue 3 C, 1997, Pages 1985-1992

  Maeda, Osamu ^a   Kikkawa, Fumitaka ^a   Tamakoshi, Koji ^a   Obata, Naoko Hasegawa ^a   Mizuno, Kimio ^a   Suganuma, Nobuhiko ^a   Tomoda, Yutaka ^a   Kuzuya, Kazuo ^b   Ishikawa, Tomohiko ^a   Hidaka, Hiroyoshi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

Adriamycin; Biochemical modulation; CKA1083; Glutathione S transferase; P glycoprotein

Indexed keywords

ANTINEOPLASTIC AGENT; CKA 1083; DOXORUBICIN; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P; N [2 (4 BENZYLOXYCARBONYLPIPERAZINYL) 1 (P METHOXYBENZYL)ETHYL] N METHYL N (5 ISOQUINOLINE)SULFONAMIDE; UNCLASSIFIED DRUG; VERAPAMIL; W 77;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RESISTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TISSUE LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; OVARY CARCINOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL SURVIVAL; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENZYME INHIBITORS; FEMALE; GLUTATHIONE TRANSFERASE; HUMANS; ISOQUINOLINES; KINETICS; OVARIAN NEOPLASMS; PIPERAZINES; RECOMBINANT PROTEINS; SULFONAMIDES; TRANSFECTION; TUMOR CELLS, CULTURED; VERAPAMIL;

EID: 0030824795     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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