The conserved HR domain of the Drosophila Suppressor 2 of zeste [Su(z)2] and murine bmi-1 proteins constitutes a locus-specific chromosome binding domain

Chromosoma

Volumn 106, Issue 2, 1997, Pages 70-80

  Sharp, Edward J ^a   Abramova, Natasha A ^a   Park, Woo Jin ^a,b   Adler, Paul N ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME PROTEIN; COMPLEMENTARY DNA; HEAT SHOCK PROTEIN 70; SIGNAL PEPTIDE;

ARTICLE; BINDING SITE; CELL NUCLEUS; COMB; DROSOPHILA; GENE DELETION; GENE LOCUS; GENE REPRESSION; GENETIC CONSERVATION; MOUSE; NONHUMAN; POLYTENE CHROMOSOME; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

ABNORMALITIES; ANIMALS; CHROMOSOME BANDING; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENES, MYC; INSECT PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSGENES; X CHROMOSOME;

MURINAE;

EID: 0030824032     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004120050226     Document Type: Article

References (73)

1. Adler P, Charlton J, Brunk B (1989) Genetic interactions of the Suppressor 2 of zeste region genes. Dev Genet 101:249-260
2. Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M, Koseki H (1996) A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development 122:1513-1522
3. Alkema MJ, van der Lugt NMT, Bobeldijk RC, Berns A, van Lohuizen M (1995) Transformation of axial skeleton due to over-expression of bmi-1 in transgenic mice. Nature 374:724-727
4. Breen TR, Duncan IM (1986) Maternal expression of genes that regulate the bithorax complex of Drosophila melanogaster. Dev Biol 118:442-456
5. Brunk B (1989) Analysis of the PAS-R in Drosophila. Doctoral dissertation. University of Virginia, Charlottesville, Va
6. Brunk BP, Adler PN (1991) The sequence of the Drosophila regulatory gene Suppressor 2 of zeste. Nucleic Acids Res 19:3149
7. Brunk BP, Martin EC, Adler PN (1991a) Molecular genetics of the Posterior Sex Combs/Suppressor 2 of zeste region ot Drosophila: aberrant expression of the Suppressor 2 of zeste gene results in abnormal bristle development. Genetics 128:119-132
8. Brunk BP, Martin EC, Adler PN (1991b) Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Nature 353:351-353
9. Bunker CA, Kingston RE (1994) Transcriptional repression by Drosophila and mammalian Polycomb group proteins in transfected mamalian cells. Mol Cell Biol 14:1721-1732
10. Busturia A, Morata G (1988) Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis. Development 104:713-720
11. Celniker SE, Sharma S, Keelan DJ, Lewis EB (1990) The molecular genetics of the bithorax complex of Drosophila: cis-regulation of the Abdominal-B domain. EMBO J 9:4277-4286
12. Chan C-S, Rastelli L, Pirrotta V (1994) A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression. EMBO J 13:2553-2564
13. Chiang A, O'Connor MB, Paro R, Simon J, Bender W (1995) Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex. Development 121:1681-1689
14. DeCamillis M, Cheng N, Pierre D, Brock HW (1992) The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb. Genes Dev 6:223-232
15. Duncan I (1986) Control of the bithorax complex functions by the segmentation gene fushi tarazu of Drosophila melanogaster. Cell 47:297-309
16. Evans GI, Lewis GK, Ramsay G, Bishop JM (1985) Isolation ot monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol 5:3610-3616
17. Franke A, DeCamillis M, Zink D, Cheng N, Brock HW, Paro R (1992) Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J 11:2941-2950
18. Freemont P (1993) The RING finger: a novel sequence motif related to the zinc finger. Ann N Y Acad Sci 68:174-192
19. Freemont PS, Hanson IM, Trowsdale J (1991) A novel cysteine-rich sequence motif. Cell 64:483-484
20. Gelhart WM, Wu CT (1982) Interactions of zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster. Genetics 102:179-189
21. Goebl MG (1991) The bmi-1 and mel-18 gene products define a new family of DNA-binding proteins involved in cell proliferation and tumorigenesis. Cell 66:623
22. Gutjahr T, Frei E, Spicer C, Baumgartner S, White R, Noll M (1995) The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family. EMBO J 14:4296-4306
23. Harding K, Levine M (1988) Gap genes define the limits of Antennapedia and bithorax gene expression during early development in Drosophila. EMBO J 7:205-214
24. Haupt Y, Alexander WS, Barri G, Klinken SP, Adams JM (1991) Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E:-myc transsenic mice. Cell 65:753-763
25. Ingham P, Martinez-Arias A (1986) The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene. Nature 32:592-597
26. Irish VF, Martinez-Arias A, Akam M (1989) Spatial regulation of the Antennapedia and Ultrabithorax homeotic genes during Drosophila early development. EMBO J 8:1527-1537
27. Irminger-Finger I, Nothiger R (1995) The Drosophila melanogaster gene lethal(3)73 Ah encodes a ring finger protein homologous to the oncoproteins MEL-18 and BMI-1. Gene 163:203-208
28. Jones RS, Gelbart WM (1990) Genetic analysis of the Enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster. Genetics 126:185-199
29. Jurgens G (1985) A group of genes controlling spatial expression of the bithorax complex in Drosophila. Nature 316:153-155
30. Kanno M, Hasegawa M, Ishida A, Isono K, Taniguchi M (1995) mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J 14:5672-5678
31. Karch F, Bender W, Weiffenbach B (1990) abdA expression in Drosophila embryos. Genes Dev 4:1573-1587
32. Klemenz R, Weber U, Gehring WJ (1987) The white gene as a marker in a new P-element vector for gene transfer in Drosophila. Nucleic Acids Res 15:3947-3959
33. Krumlauf R (1993) Hox genes and pattern formation in the branchial region of the vertebrate head. Trends Genet 9:106-112
34. Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276:565-570
35. Locke J, Kotarski M, Tartoff K (1988) Dosage-dependent modifiers of position effect variegation in Drosophila and a mass-action model that explains their effects. Genetics 120:181-198
36. Lonie A, D'andrea R, Paro R, Saint R (1994) Molecular characterization of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression. Development 120:2629-2636
37. Lovering R, Hanson I, Borden K, Martin S, O'Reilly N, Evan G, Rahman D, Pappin D, Trowsdale J, Freemont P (1993) Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci 90:2112-2116
38. Lundell MJ, Hirsh J (1994) A new visible light DNA fluorochrome for confocal microscopy. Biotechniques 16:434-440
39. Martin E, Adler P (1993) The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein. Development 117:641-655
40. McGinnis W, Krumlauf R (1992) Homeobox genes and axial patterning. Cell 68:283-302
41. McKeon J, Brock H (1991) Interactions of the Polycomb group of genes with homeotic loci of Drosophila. Rouxs Arch Dev Biol 199:387-396
42. Messmer S, Franke A, Paro R (1992) Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes Dev 6:1241-1254
43. Muller J (1995) Transcriptional silencing by the Polycomb protein in Drosophila embryos. EMBO J 14:1209-1220
44. Muller I, Gaunt S, Lawrence P (1995) Function of the Polycomb protein is conserved in mice and flies. Development 121: 2847-2852
45. Neckameyer W, White K (1993) Drosophila tyrosine hydroxylase is encoded by the pale locus. J Neurogenet 8:189-199
46. Pirrotta V (1988) Vectors for P-element transformation in Drosophila. In: Rodrigues RL, Denhardt DT (eds) Vectors. A survey of molecular cloning vectors and their uses. Butterworths; Boston and London, pp 437-456
47. Pirrotta V (1995) Chromatin complexes regulating gene expression in Drosophila. Curr Opin Genet Dev 5:466-472
48. Platero JS, Sharp EJ, Adler PN, Eissenberg JC (1996) In vivo assay for protein-protein interactions using Drosophila chromosomes. Chromosoma 104:393-404
49. Qian S, Capovilla M, Pirrotta V (1991) The bx region enhancer, a distant cis-control element of the Drosophila Ubx gene and its regulation by hunchback and other segmentation genes. EMBO J 10:1415-1425
50. Rastelli L, Chan C, Pirotta V (1993) Related chromosome binding sites for zeste, suppressors of zeste, and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J 12:1513-1522
51. Reijnen MJ, Hamer KM, den Blaauwen JL, Lambrechts C, Schoneveld I, van Driel, Otte AP (1995) Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other. Mech Dev 53:35-46
52. Rubin G, Spradling A (1982) Genetic transformation of Drosophila with transposable element vectors. Science 218:348-353
53. Sambrook J, Fritsch EF, Maniatis T (1994) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
54. Sharp EJ, Martin EC, Adler PN (1994) Directed overexpression of Suppressor 2 of zeste and Posterior sex combs results in bristle abnormalities in Drosophila melanogaster. Dev Biol 161:379-392
55. Simon J, Chiang AC, Bender W (1992) Ten different Polycomb-group genes are required for spatial control of the abdA and AbdB homeotic products. Development 114:493-505
56. Simon J, Chiang A, Bender W, Shimell MJ, O'Connor M (1993) Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products. Dev Biol 158:131-144
57. Soto MC, Chou TB, Bender W (1995) Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogaster. Genetics 140:231-243
58. Struhl G, Akam ME (1985) Altered distribution of Ultrabithorax and in extra sex combs mutant embryos of Drosophila. EMBO J 4:3259-3264
59. Suter B, Steward R (1991) Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation. Cell 76:917-926
60. Tagawa M, Sakamoto T, Shigemoto K, Matsubara H, Tamura Y, Ito T, Nakamura I, Okitsu A, Imai K, Taniguchi M (1990) Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. J Biol Chem 265:20021-20026
61. van der Lugt NMT, Domen J, Linders K, Van Roon M, Robanus-Maandag E, Te Riele H, Van der Valk M, Deschamps J, Sofroniew M, Van Lohuizen M, Berns A (1994) Posterior transformations, neurological abnormalities and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8:757-769
62. van Lohuizen M, Frasch M, Wientjens F, Berns A (1991a) Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 353:353-355
63. van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A (1991b) Identification of cooperating oncogenes in E:-myc transgenk mice by provirus tagging. Cell 65:737-752
64. Wedeen C, Harding K, Levine M (1986) Spatial regulation of Antennapedia and bithorax gene expression by the Pc locus in Drosophila. Cell 44:739-748
65. White RAH, Akam ME (1985) Contrabithorax mutations cause inappropriate expression of Ultrabithorax products in Drosophila. Nature 318:567-569
66. White RAH, Lehmann R (1986) A gap gene, hunchback, regulates the expression of Ultrabithorax. Cell 47:311-321
67. Wright TRF, Black BC, Bishop CP, Marsh JL, Pentz ES, Steward R, Wright EY (1982) The genetics of dopa decarboxylase in Drosophila melanogaster. Mol Gen Genet 188:18-26
68. Wu CT (1982) A genetic analysis of tansvection. Doctoral dissertation, Harvard University, Cambridge, Mass
69. Wu CT, Howe M (1995) A genetic analysis of the Suppressor 2 of zeste complex of Drosophila melanogaster. Genetics 140: 139-181
70. Wu CT, Jones RS, Lasko PF, Gelbart WM (1989) Homeosis and the interaction of zeste and white in Drosophila. Mol Gen Genet 218:559-564
71. Zhang CC, Muller J, Hock M, Jackle H, Bienz M (1991) Target sequences for hunchback in a control region conferring Ultrabithorax expression boundaries. Development 113:1171-1179
72. Zink B, Paro R (1989) In vivo binding pattern of a trans-regulator of homeotic genes in Drosophila melanogaster. Nature 337: 468-171
73. Zink B. Engstrom Y, Gehring W, Paro R (1991) Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster. EMBO J 10:153-162