Elevated plasma levels of reduced homocysteine in common variable immunodeficiency - A marker of enhanced oxidative stress

European Journal of Clinical Investigation

Volumn 27, Issue 9, 1997, Pages 723-730

  Aukrust, P ^a,c   Berge, R K ^b   Muller F ^a   Ueland, P M ^b   Svardal, A M ^b   Froland S S ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Common variable immunodeficiency; Homocysteine; Lipid peroxidation; Oxidative stress; Vitamin E; Carotene

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE; HOMOCYSTEINE; MARKER;

ADULT; ARTICLE; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; HUMAN; IMMUNOPATHOGENESIS; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL;

EID: 0030823822     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1997.18807328.x     Document Type: Article

References (31)

1. Sies H. Oxidative stress: from basic research to clinical application. Am J Med 1991;91(Suppl. 3C):31S-38S.
2. Halliwell B, Gutteridge JMC, Ross CE. Free radicals, antioxidants, and human disease: where are we now? J Clin Lab Med 1992; 119:598-619.
3. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90:7915-22.
4. Staal FTJ, Ela SW, Roderer M, Anderson MT, Herzenberg LA, Herzenberg LA. Glutathione deficiency and human immunodeficiency virus infection. Lancet 1992;339:909-12.
5. + lymphocytes associated with disturbed intracellular redox balance in human immunodeficiency virus type 1 infection. Blood 1995;86:258-67.
6. Spickett GP, Misbah SA, Chapel HM. Primary antibody deficiency in adults. Lancet 1991;337:281-4.
7. WHO Scientific Group Report. Primary immunodeficiency diseases. Clin Exp Immunol 1995;97(Suppl. 1):1-24.
8. Spickett, GP, Webster ADB, Farrant J. Cellular abnormalities in common variable immunodeficiency. Immunodefic Rev 1991;2: 199-219.
9. Aukrust P, Müller F, Frøland SS. Enhanced generation of reactive oxygen species in monocytes from patients with common variable immunodeficiency. Clin Exp Immunol 1994;97:232-8.
10. + lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor α system: possible immunopathogenic role of oxidative stress. Blood 1995;86:1383-91.
11. Aukrust P, Lien E, Kristoffersen AK et al. Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency - possible immunologic and clinical consequences. Blood 1996;87:674-81.
12. Meister A, Anderson ME. Glutathione. Annu Rev Biochem 1983; 52:711-60.
13. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest 1996;98:5-7.
14. Niki E, Nogouchi N, Tsuchihashi H, Gotoh N. Interaction among vitamin C, vitamin E, and β-carotene. Am J Clin Nutr 1995;62 (Suppl.):1322S-1326S.
15. Meister A. Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem 1994;269:9397-400.
16. + lymphocytes. Clin Immunol Immunopathol 1994;70:217-24.
17. Mansoor MA, Svardal AM, Ueland PM. Determination of in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in plasma. Anal Biochem 1992;200:218-29.
18. Arnaud J, Fortis I, Blachier S, Kia D, Favier A. Simultaneous determination of retinol, α-tocopherol and β-carotene by isocratic high-performance liquid chromatography. J Chromatogr 1991;572: 103-16.
19. Li X-X, Chow CK. An improved method for the measurement of malondialdehyde in biologic samples. Lipids 1994;29:73-5.
20. Rock CL, Jacob RA, Bowen PE. Update on the biological characteristics of the antioxidant micronutrients: vitamin C, vitamin E. and the carotenoids. J Am Diet Assoc 1996;96:693-702.
21. Das BS, Thurnham DI, Das DB. Plasma α-tocopherol, retinol, and carotenoids in children with falciparum malaria. Am J Clin Nutr 1996;64:94-100.
22. Greenspan HC, Aruoma OI. Oxidative stress and apoptosis in HIV infection: a role for plant-derived metabolites with synergistic antioxidant activity. Immunol Today 1994;15:209-13.
23. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intake. JAMA 1995;274:1049-57.
24. Ueland PM, Mansoor MA, Guttormsen AB et al. Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status - a possible element of the extracellular antioxidant system. J Nutr 1996;127:1281S-1284S.
25. Müller F, Svardal AM, Aukrust P, Berge RK, Ueland PM, Frøland SS. Elevated plasma concentration of reduced homocysteine in patients with human immunodeficiency virus infection. Am J Clin Nutr 1996;63:242-8.
26. Svardal AM, Mansoor MA, Ueland PM. Determination of reduced, oxidized, and protein-bound glutathione in human plasma with precolumn derivation with monobromobimane and liquid chromatography. Anal Biochem 1990;184:338-46.
27. Sies H, Stahl W. Vitamins E and C, β-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 1995;62(Suppl.):1315S-1321S.
28. Staal FTJ, Anderson MT, Staal GEJ, Herzenberg LA, Herzenberg LA. Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx. Proc Natl Acad Sci USA 1994;91:3619-22.
29. Packer L. New horizons in vitamin E research - the vitamin E cycle, biochemistry, and clinical application. In: Ong ASH, Packer L, eds. Lipid soluble antioxidants: biochemistry and clinical applications. Berlin: Birkhäuser Verlag, 1992:1-14.
30. Baum MK, Shor-Posner G, Bonvehi P et al. Influence of HIV infection on vitamin status and requirements. Ann NY Acad Sci 1992;669:165-74.
31. Meydani SN, Wu D, Santos MS, Hayek MG. Antioxidants and immune responses in aged persons: overview of present evidence. Am J Clin Nutr 1995;62(Suppl.):1462S-1476S.