Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer

Surgery

Volumn 122, Issue 2, 1997, Pages 228-234

  Coveney, Eamonn ^a   Wheatley III, Grayson H ^a   Lyerly, H Kim ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE IMMUNIZATION; ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; BREAST CANCER; CELL MIGRATION; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EFFECTOR CELL; HELPER CELL; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TUMOR GROWTH;

EID: 0030822648     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-6060(97)90013-1     Document Type: Conference Paper

References (22)

1. Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991;9:271-96.
2. Sornasse T, Flamand V, De Becker G, et al. Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo. J Exp Med 1992;175:15-21.
3. Inaba K, Metlay J, Crowley M, et al. Dendritic cells as antigen presenting cells in vivo. Int Rev Immunol 1990;6:197-206.
4. Crowley M, Inaba K, Steinman R. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J Exp Med 1990;172:383-90.
5. Steinman R, Witmer-Pack M, Inaba K. Dendritic cells: antigen presentation, assessory function and clinical relevance. Adv Exp Med Biol 1993;329:1-9.
6. Inaba K, Romani N, Steinman R. An antigen-independent contact mechanism as an early step in T cell proliferative responses to dendritic cells. J Exp Med 1989;170:527-42.
7. Mayordomo J, Zorina T, Storkus W, et al. Bone marrow derived dendritic cells pulsed with synthetic tumor peptides elicit protective and therapeutic antitumor immunity. Nature Medicine 1995;1:1297-302.
8. Boczkowski D, Nair S, Snyder D, Gilboa E. Dendritic cells pulsed with RNA are potent antigen presenting cells in vitro and in vivo. J Exp Med 1996;184:465-72.
9. Flamand V, Sornasse T, Thielman K, et al. Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur J Immunol 1994;24:605-10.
10. Porgador A, Gilboa E. Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes. J Exp Med 1995;182:255-60.
11. Anichini A, Mortarini R, Maccalli C, et al. Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1 restricted immune repertoire to melanoma. J Immunol 1996;156:208-17.
12. + cytolytic T lymphocytes. J Exp Med 1996;183:791-800.
13. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α. J Exp Med 1994;179:1109-18.
14. O'Doherty U, Steinman RM, Peng M, et al. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med 1993;178:1067-78.
15. Inaba K, Inaba M, Romani H, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992;176:1693-702.
16. Romani N, Gruner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994;180:8393.
17. Knight S, Hunt R, Dore C, Medawar P. Influence of dendritic cells on tumor growth. Proc Natl Acad Sci U S A 1985;82:4495-7.
18. Caux C, Liu Y, Banchereau J. Recent advances in the study of dendritic cells and follicular dendritic cells. Immunol Today 1995;16:2-4.
19. Grabbe S, Bruvers S, Gallo R, et al. Tumor antigen presentation by murine epidermal cells. J Immunol 1991;146:3656-61.
20. Porgador A, Snyder D, Gilboa E. Induction of antitumor immunity using bone marrow generated dendritic cells. J Immunol 1996;156:2918-26.
21. Shimizu J, Sud T, Yoshioka T, et al. Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells. J Immunol 1989;142:1053-9.
22. Cohen PJ, Cohen PA, Rosenberg SA, et al. Murine epidermal Langerhans cells and splenic dendritic cells present tumor-associated antigens to primed T cells. Eur J Immunol 1994;24:315-9.