NAD- and NADP-dependent 11β-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition

Acta Pharmacologica Sinica

Volumn 18, Issue 6, 1997, Pages 481-485

  Wang, Mao Shan ^a,b   Lorenzo, Beverly J ^a   Reidenberg, Marcus M ^a  

^a Department of Obstetrics Gynecology   (United States)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Gossypol; Hydroxysteroid dehydrogenases; Hypokalemia; Isoenzymes; Steroids

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GOSSYPOL; ISOENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; GUINEA PIG; HYPOKALEMIA; KIDNEY; MALE; NONHUMAN;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CONTRACEPTIVE AGENTS, FEMALE; GOSSYPOL; GUINEA PIGS; HYDROXYSTEROID DEHYDROGENASES; ISOENZYMES; KIDNEY CORTEX; MALE; MICROSOMES; NAD; NADP;

EID: 0030822359     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. National coordinating group on male antifertility agents. Gossypol - a new antifertility agent for males. Chin Med J 1978; 4: 417-28.
2. Wang C, Yeung RTT. Gossypol and hypokalaemia. Contraception 1985; 32: 237-52.
3. Monder C, Shackleton CHL, Bradlow HL, New MI, Stoner E, Iohan F, et al. The syndrome of apparent mineralocorticoid excess: its association with 11β-dehydrogenase and 5β-reductase deficiency and some consequences for corticosteroid metabolism. J Clin Endocr Metab 1986; 63: 550-7.
4. Walker BR, Campbell JC, Williams BC, Edwards CR. Tissue-specific distribution of the NAD( + )-dependent isoform of 11β-hydroxysteroid dehydrogenase. Endocrinology 1992; 131: 970-2:
5. Mercer WR, Krozowski ZS. Localization of an 11β-hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney. Endocrinology 1992; 130: 540-3.
6. Sang GW, Lorenzo B, Reidenberg MM. Inhibitory effects of gossypol on corticosteroid 11β-hydroxysteroid dehydrogenase from guinea pig kidney: a possible mechanism for causing hypokalemia. J Steroid Biochem Mol Biol 1991; 39: 169-76.
7. Song D, Lorenzo B, Reidenberg MM. Inhibition of 11β-hydroxy-steroid dehydrogenase by gossypol and bioflavonoids. J Lab Clin Med 1992; 120: 792-7.
8. National Collaborative Team on the Clinical Study of Gossypol as Male Antifertility Drug. The clinical study of gossypol in 8806 men. Reprod Contracep 1985; 5 (4): 5-11.
9. Roy AK. Regulation of steroid hormone action in target cells by specific hormone-inactivating enzymes. Proc Soc Exp Biol Med 1992; 199: 265-72.
10. Ferguson MM, Glen JB, Mason DK. Cortisol utilization by salivary gland, kidney and adrenal cortex. J Endocrinol 1970; 47: 511-5.
11. Lamey PJ, Ferguson MM, Marshall W, Wallace M, Wiesenfeld D. Study of the ductal epithelial cell component of human labial salivary glands in vitro. J Biol Buccale 1984; 12: 191-9.
12. Krozowski ZS, Provencher PH, Smith RE, Obeyesekere VR, Mercer WR, Albiston AL. Isozymes of 11β-hydroxysteroid dehydrogenase: which enzyme endows mineralocorticoid specificity? Steroids 1994; 59: 116-20.