Substance P augments fibrogenic cytokine-induced fibroblast proliferation: Possible involvement of neuropeptide in tissue fibrosis

Journal of Dermatological Science

Volumn 15, Issue 3, 1997, Pages 201-206

  Katayama, Ichiro ^a,b   Nishioka, Kiyoshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytokine; Fibrosis; Histamine; Mast cell; Systemic sclerosis

Indexed keywords

BUTYRIC ACID; CALCITONIN GENE RELATED PEPTIDE; CONCANAVALIN A; CYTOKINE; CYTOKINE ANTIBODY; FK 224; HISTAMINE; INTERLEUKIN 3; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ A; NEUROPEPTIDE; PLATELET DERIVED GROWTH FACTOR; SPANTIDE; SUBSTANCE P; SUBSTANCE P ANTAGONIST; TRANSFORMING GROWTH FACTOR BETA; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; FIBROBLAST; FIBROSIS; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; ANIMALS; CELL DIVISION; CELL LINE; CYTOKINES; FIBROBLASTS; FIBROSIS; HISTAMINE; MAST CELLS; MICE; MICE, INBRED BALB C; NEUROPEPTIDES; SUBSTANCE P;

EID: 0030822201     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(97)00608-7     Document Type: Article

References (19)

1. Nishioka K, Kobayashi S, Katayama I, Takijiri C: Mast cell numbers in diffuse scleroderma. Arch Dermatol 123: 205-208, 1987.
2. Katayama I, Nishioka K: The role of mast cells and their mediators in the pathogenesis of scleroderma. In Proceedings of the Scleroderma International Symposium - Current Topics in Scleroderma. Edited by: S. Mori. 1992, pp. 181-186.
3. Kovacs EJ: Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol Today 12: 17-23, 1991.
4. Morimoto H, Murai M, Maeda Y et al.: FK224, a novel cyclopeptides substance P antagonist with NK1 and NK2 receptor selectivity. J Pharmacol Exp Ther 262: 398-402, 1992.
5. Fujii T, Murai M, Morimoto H et al.: Pharmacological profile of a high affinity dipeptide NK 1 receptor antagonist, FK888. Br J Pharmacol 107: 785-789, 1992.
6. Weiche E, Hartshuh W: Multiple peptides in cutaneous nerves. Regulation under physiological conditions and a pathogenic role in skin disease? Semin Dermatol 7: 284-300, 1988.
7. Katayama I, Yokozeki H, Nishioka K: Mast cell derived mediators induce epidermal cell proliferation: clue for lichenified skin lesion formation in atopic dermatitis. Int Arch Allergy Appl Immunol 98: 410-414, 1992.
8. Hatamochi A, Fujiwara K, Ueki H: Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin. Arch Dermatol Res 277: 60-64, 1985.
9. Gordon JR, Galli SJ: Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via Fc∈R1. Role for mast cell derived transforming growth factor β and tumor necrosis factor α. J Exp Med 180: 2027-2037, 1994.
10. Levi-Schaffer F, Rubinchik F: Activated mast cells are fibrogenic for 3T3 fibroblasts. J Invest Dermatol 104: 999-1003, 1995.
11. Sempowski GD, Beckmann MP, Derdak S, Phipps RP: Subsets of murine lung fibroblasts express membrane bound and soluble IL4 receptors. Role of IL4 in enhancing fibroblast proliferation and collagen synthesis. J Immunol 152: 3606-3613, 1994.
12. Gordon JR, Burd PR, Galli S: Mast cell as a source of multi-functional cytokines. Immunol Today 11: 458-464, 1990.
13. Galli SJ: New concepts about the mast cell. N Engl J Med 328: 257-265, 1993.
14. Nilsson J, von Euler AM, Dalsgaard CJ: Stimulation of connective tissue by substance P and substance K. Nature 315: 61-63, 1985.
15. Tanaka T, Danno K, Ikai K, Imamura S: Effects of substance P and substance K on the growth of cultured keratinocytes. J Invest Dermatol 90: 399-401, 1988.
16. Erjavec F, Lembeck F, Florjanc-Irman T et al.: Release of histamine by substance P. Naunyn-Schmiedeberg's Arch Pharmacol 317: 67-70, 1981.
17. Claman HN: Mast cells and fibrosis. The relevance to scleroderma. Rheum Clin North Am 16: 141-151, 1990.
18. Weinstock JV, Blum AM: Tachykinin production in granulomas of murine Schistosomiasis mansoni. J Immunol 142: 3256-3261, 1989.
19. Kimball ES, Fisher MC: Potentiation of IL1-induced Balb/3T3 fibroblast proliferation by neuropeptides. J Immunol 141: 4203-4208, 1988.