Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII

Journal of Biological Chemistry

Volumn 272, Issue 39, 1997, Pages 24121-24124

  Swaroop, Manju ^a   Moussalli, Micheline ^a   Pipe, Steven W ^a   Kaufman, Randal J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; EDETIC ACID; IMMUNOGLOBULIN BINDING FACTOR; METAL ION; MUTANT PROTEIN; PHENYLALANINE; SERINE; THROMBIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; CELL STRAIN COS1; CHELATION; CHO CELL; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION; SITE DIRECTED MUTAGENESIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; COS CELLS; EDETIC ACID; FACTOR VIII; HEAT-SHOCK PROTEINS; IMMUNOGLOBULIN HEAVY CHAINS; MOLECULAR CHAPERONES; MUTAGENESIS, SITE-DIRECTED;

ANIMALIA;

EID: 0030821993     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.39.24121     Document Type: Article

References (25)

1. Toole, J. J., Knopf, J. L., Wozney, J. M., Sultzman, L. A., Bucker, R. L., Pittman, D. D., Kaufman, R. J., Brown, E., Shoemaker, C., Orr, E. C., Amphlett, G. W., Foster, W. B., Coe, M. L., Knutson, G. J., Fass, D. N., and Hewick, R. M. (1984) Nature 312, 342-347
2. Vehar, G. A., Keyt, B., Eaton, D., Rodriguez, H., O'Brien, D. P., Rotblat, F., Oppermann, H., Keck, R., Wood, W. I., Harkins, R. N., Tuddenham, E. G. D., Lawn, R. M., and Capon, D. J. (1984) Nature 312, 337-342
3. Jenny, R. J., Pittman, D. D., Toole, J. J., Kriz, R. W., Aldape, R. A., Hewick, R. M., Kaufman, R. J., and Mann, K. G. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 4846-4850
4. Kane, W. H., and Davie, E. W. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 6800-6804
5. Kaufman, R. J., Wasley, L. C., and Dorner, A. J. (1988) J. Biol. Chem. 263, 6352-6362
6. Munro, S., and Pelham, H. R. B. (1986) Cell 46, 291-300
7. Dorner, A. J., Wasley, L. C., and Kaufman, R. J. (1989) J. Biol. Chem. 264, 20602-20607
8. Flynn, G. C., Chappell, T. G., and Rothman, J. E. (1989) Science 245, 385-390
9. Dorner, A. J., Wasley, L. C., and Kaufman, R. J. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 7429-7432
10. Pittman, D. D., Tomkinson, K. N., and Kaufman, R. J. (1994) J. Biol. Chem. 269, 17329-17337
11. Morris, J. A., Dorner, A. J., Edwards, C. A., Hendershot, L. M., and Kaufman, R. J. (1997) J. Biol. Chem. 272, 4327-4334
12. Marquette, K. A., Pittman, D. D., and Kaufman, R. J. (1995) J. Biol. Chem. 270, 10297-10303
13. Blond-Elguindi, S., Cwirla, S. E., Dower, W. J., Lipshutz, R. J., Sprang, S. R., Sambrook, J. F., and Gething, M. J. (1993) Cell 75, 717-728
14. Kaufman, R. J., Davies, M. V., Wasley, L. C., and Michnick, D. (1991) Nucleic Acids Res. 19, 4485-4490
15. Kaufman, R. J. (1989) Methods Enzymol. 185, 487-511
16. Pittman, D. D., and Kaufman, R. J. (1993) Methods Enzymol 222, 236-260
17. Kaufman, R. J. (1989) Methods Enzymol. 185, 537-566
18. Michnick, D. A., Pittman, D. D., Wise, R. J., and Kaufman, R. J. (1994) J. Biol. Chem. 269, 20095-20102
19. Fay, P. J., Beattie, T. L., Regan, L. M., O'Brien, L. M., and Kaufman, R. J. (1996) J. Biol. Chem. 271, 6027-6032
20. Zatloukal, K., Cotten, M., Berger, M., Schmidt, W., Wagner, E., and Birnstiel, M. L. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 5148-5152
21. Bihoreau, N., Pin, S., de Kersabiec, A.-M., Vidot, F., and Fontaine-Aupart, M. P. (1994) Eur. J. Biochem. 220, 41-48
22. Tagliavacca, L., Moon, N., Dunham, W. R., and Kaufman, R. J. (1997) J. Biol. Chem. 272, in press
23. Zaitseva, I., Zaitsev, V., Card, K. M., Bax, B., Ralph, A., and Lindley, P. (1996) Bioinorg. Chem. 1, 15-23
24. Pemberton, S., Lindley, P., Zaitsev, V., Card, G., and Tuddenham, E. G. D. (1997) Blood 89, 2413-2421
25. Lollar, P., and Parker, C. G. (1991) J. Biol. Chem. 267, 23652-23657