Ventilation inhomogeneities and mixed venous blood N2 in multibreath N2 washout

Respiration Physiology

Volumn 110, Issue 1, 1997, Pages 47-56

  Cruz, Julio C ^a,c   Jeng, Duen Ren ^b,c   Han, Decai ^b,c   Wu, Guoming ^b,c   Flores, Xavier F ^a,c  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b The University of Toledo   (United States)

^c Flower Hospital   (United States)

Author keywords

Gas exchange; Inert gases; Lung gas mixing; Lung washout; Models; Parallel heterogeneity; Stratified

Indexed keywords

ARTICLE; FUNCTIONAL RESIDUAL CAPACITY; GAS EXCHANGE; GAS TRANSPORT; HUMAN; LUNG MODEL; LUNG PERFUSION; NONHUMAN; PRIORITY JOURNAL; THEORY;

COMPUTER SIMULATION; FUNCTIONAL RESIDUAL CAPACITY; HUMANS; MODELS, BIOLOGICAL; NITROGEN; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; RESPIRATORY MECHANICS;

EID: 0030821731     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(97)00068-6     Document Type: Article

References (21)

1. Bowes C., Cumming G., Horsfield K., Loughhead J., Preston S. Gas mixing in a model of the pulmonary acinus with asymmetrical alveolar ducts. J. Appl. Physiol. 52:1982;624-633.
2. Crawford A.B.H., Makowska M., Paiva M., Engel L.A. Convection- and diffusion-dependent ventilation maldistribution in normal subjects. J. Appl. Physiol. 59:1985;838-846.
3. Crawford A.B.H., Makowska M., Engel L.A. Effect of bronchomotor tone on static mechanical properties of lung and ventilation distribution. J. Appl. Physiol. 63:1987;2278-2285.
4. Cruz J.C. A combined parallel and series distribution model of inspired inert gases. Respir. Physiol. 86:1991;1-14.
5. 2 washout. Eur. Respir. J. 9:1996;68s.
6. Haefeli-Bleuer B., Weibel E.R. Morphometry of the human pulmonary acinus. Anat. Rec. 220:1988;401-414.
7. Hansen J.E., Ampaya E.P. Human airspace shapes, sizes, areas and volumes. J. Appl. Physiol. 38:1975;990-995.
8. 2 washout modeled by non-uniform 7 parallel regions and a diffusion-convection equation with a source term. FASEB J. 10:1996;A364.
9. Luijendijk S.C.M., Zwart A., de Vries W.R., Salet W.M. The sloping aveolar plateau at synchronous ventilation. Pflügers Arch. Eur. J. Physiol. 384:1980;267-277.
10. Milic-Emili J., Henderson J.A.M., Dolovich M.B., Kaneko K. Regional distribution of inspired gas in the lung. J. Appl. Physiol. 21:1966;749-759.
11. Neufeld G.R., Gobran S.R., Baumgardner J.E., Aukburg S.J., Schriner M.S., Scherer P.W. Diffusivity, respiratory rate and tidal volume influence inert gas expirograms. Respir. Physiol. 84:1991;31-47.
12. Paiva M. Gas transport in the human lung. J. Appl. Physiol. 25:1973;401-410.
13. Paiva M., Engel L.A. Pulmonary interdependece of gas transport. J. Appl. Physiol. 47:1979;296-305.
14. Paiva M., Engel L.A. Model analysis of gas distribution within human lung acinus. J. Appl. Physiol. 56:1984;418-425.
15. Scherer P.W., Shendalman L.H., Green N.M. Simultaneous diffusion and convection in single breath lung washout. Bull. Math. Biophys. 34:1972;393-412.
16. 2 and inert gas washout. J. Appl. Physiol. 64:1988;1022-1029.
17. Scherer P.W., Neff J.D., Baumgardner J.E., Neufeld G.R. The importance of a source term in modeling multibreath inert gas washout. Respir. Physiol. 103:1996;99-103.
18. Sikand R., Cerretelli P., Farhi L.E. Effects of V̇A and V̇A/Q̇ distribution and of time on the alveolar plateau. J. Appl. Physiol. 21:1966;1331-1337.
19. Weibel, E.R., 1963. Morphometry of the Human Lung. Springer-Verlag, Berlin.
20. West J.B. Regional differences in gas exchange in the lung of erect man. J. Appl. Physiol. 17:1962;893-898.
21. Wu G., Jeng D.R., Flores X.F., Cruz J.C. Convection-diffusion mechanisms in a 7 region lung model. FASEB J. 7:1993;A230.