Abnormality in fatty acid composition of gastric mucosal phospholipids in patients with liver cirrhosis and its correction with a polyunsaturated fatty acid-enriched soft oil capsule

Journal of Gastroenterology and Hepatology (Australia)

Volumn 12, Issue 9-10, 1997, Pages 644-652

  Miyamoto, Ayumu ^a   Wakabayashi, Hiroyuki ^a   Watanabe, Akiharu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Gastric mucosal lesion; Liver cirrhosis; Phospholipid; Polyunsaturated fatty acid; PUFA enriched soft oil capsule

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; SERUM ALBUMIN;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG CAPSULE; ENDOSCOPY; FAT INTAKE; FEMALE; GASTRITIS; HUMAN; HUMAN TISSUE; LIPID COMPOSITION; LIVER CIRRHOSIS; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH BIOPSY; STOMACH MUCOSA LESION;

EID: 0030819713     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1997.tb00528.x     Document Type: Article

References (25)

1. McCormack TT, Sims J, Eyre-Brook IS et al. Gastric lesions in portal hypertension: inflammatory gastritis on congestive gastropathy? Gut 1985; 26: 1226-32.
2. Hosokawa Y. Mucosal lesions of the stomach in liver cirrhosis with a special reference to phospholipid metabolism. Gastroenterol. Jpn. 1991; 26: 329-35.
3. Arakawa T, Satoh H, Fukuda T, Nakamura H, Kobayashi K. Endogenous prostaglandin E2 in gastric mucosa of patients with alcoholic cirrhosis and portal hypertension. Gastroenterology 1987; 93: 135-40.
4. Casadevall M, Panes J, Pique JM, Marroni N, Bosch J, Whittle BJ. Involvement of nitric oxide and prostaglandins in gastric mucosal hyperemia of portal hypertensive anesthetized rats. Hepatology 1993; 18: 628-34.
5. Nardone G, d'Armiento F, Corso G, Coscione P, Esposito M, Budillon G. Lipids of human gastric mucosa: effect of Helicobacter pylori infection and nonalcoholic cirrhosis. Gastroenterology 1994; 107: 362-8.
6. Gunnlaugsson O, Berkowitz D. Individual free fatty acids in patients with liver disease. Am. J. Dig. Dis. 1977; 22: 1005-9.
7. Okita M, Watanabe A, Tsuji T. Lipid malnutrition of patients with liver cirrhosis: effect of low intake of dietary lipid on plasma fatty acid composition. Acta Med. Okayama 1989; 43: 39-45.
8. Cabre E, Abad-Lacruz A, Nunez MC et al. The relationship of plasma polyunsaturated fatty acid deficiency with survival in advanced liver cirrhosis: multivariate analysis. Am. J. Gastroenterol. 1993; 88: 718-22.
9. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of oesophagus for bleeding oesophageal varices. Br. J. Surg. 1973; 60: 646-9.
10. D'Amico G, Montalbano L, Traina M et al. Natural history of congestive gastropathy in cirrhosis. Gastroenterology 1990; 99: 1558-64.
11. Kreuning J, Lindeman J, Biemond I, Lamers CB. Relation between IgG and IgA antibody titres against Hclicobacter pylori in serum and severity of gastritis in asymptomatic subjects. J. Clin. Pathol. 1994; 47: 227-31.
12. Bligh EG, Dyer WG. A rapid method of total lipid extraction and purification. J. Biochem. Physiol 1972; 37: 911-7.
13. Fleischer S, Rouser G, Siakotos AN. Quantitative analysis of phospholipids by thin layer chromatography and phosphorus analysis of spots. Lipid 1966; 1: 85-7.
14. Sato Y, Mukai K, Watanabe S, Goto M, Shimosato Y. The AMeX method. A simplified technique of tissue processing and paraffin embedding with improved preservation of antigens for immunostaining. Am. J. Pathol. 1986; 125: 431-5.
15. Kao YC, Lichtenberger LM. Localization of phospholipid-rich zones in rat gastric mucosa: possible origin of a protective Hydrophobic luminal lining. J. Histochem. Cytochem. 1987; 35: 1285-98.
16. Panes J, Bordas JM, Pique JM et al. Increased gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy. Gastroenterology 1992; 103: 1875 82.
17. Okita M, Miyamoto A, Wakabayashi H, Watanabe A. Improvement of polyunsaturated fatty acid deficiency in decompensated cirrhotic patients by arachidonic acidrich oil capsules. In: Yasugi T, Nakamura H, Soma M, eds. Advances in Polyunsaturated Fatty Acid Research. Tokyo: Excerpta Medica, 1993; 241-2.
18. Murty VL, Sarosiek J, Slomiany A, Slomiany BL. Effect of lipids and proteins on the viscosity of gastric mucus glycoprotein. Biochem. Biophys. Res. Commun. 1984; 121: 521-9.
19. Slomiany A, Jozwiak Z, Takagi A, Slomiany BL. The role of covalently bound fatty acids in the degradation of human gastric mucus glycoprotein. Arch. Biochem. Biophys. 1984; 229: 560-7.
20. Hills BA, Butler BD, Lichtenberger LM. Gastric mucosal barrier: Hydrophobic lining to the lumen of the stomach. Am. J. Physiol. 1983 244: G561-8.
21. Stubbs CD, Smith AD. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochem. Biophys. Acta 1984; 779: 89 137.
22. Okita M, Watanabe A, Tsuji T. Beneficial effect of polyunsaturated fatty acids supplemented diet on altered composition of plasma fatty acids in patients with liver cirrhosis. J. Clin. Biochem. Nutr. 1989; 6: 213-20.
23. Bernhard W, Linck M, Beinborn M, Schunemann P, Sewing KF. Phospholipid synthesis in isolated porcine gastric mucous cells. Pharmacology 1994; 48: 176-86.
24. Robert A. Cytoprotection by prostaglandins. Gastroenterology 1979; 77: 761-7.
25. Meydani SN, Lichtenstein AH, Cornwall S et al. Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived N-3 fatty acid enrichment. J. Clin. Invest. 1993; 92: 105-13.