Comparison of the combination of enalapril and a very low dose of hydrochlorothiazide with atenolol in patients with mild-to moderate hypertension

American Journal of Hypertension

Volumn 10, Issue 8, 1997, Pages 899-904

  Os, Ingrid ^a   Hotnes, Tom ^b   Dollerup, Jens ^c   Mogensen, Carl Erik ^d  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b Merck Research Laboratories ^*  (Norway)

^c MERCK RESEARCH LABORATORIES   (United States)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Atenolol; Combination therapy; Enalapril; Hydrochlorothiazide; Hypertension

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; HYDROCHLOROTHIAZIDE;

ARTICLE; ASTHENIA; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VERTIGO;

ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; ATENOLOL; BLOOD PRESSURE; DIURETICS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ENALAPRIL; FEMALE; HUMANS; HYDROCHLOROTHIAZIDE; HYPERTENSION; MALE; MIDDLE AGED; SODIUM CHLORIDE SYMPORTER INHIBITORS;

EID: 0030819390     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(97)00110-6     Document Type: Article

References (15)

1. Collins R, Peto R, MacMahon S, et al: Blood pressure, stroke and coronary hearth disease. Part 2, short term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990;335:827-838.
2. Lithell HOL: Effect of antihypertensive drugs on insulin, glucose and lipid metabolism. Diabetes Care 1991; 14:203-209.
3. Andersson PE, Johansson J, Berne C, Lithell H: Effects of selective alpha 1 and beta 1-adrenoceptor blockade on lipoprotein and carbohydrate metabolism. J Hum Hypertens 1994;8:219-226.
4. Lardinois CK, Neuman SL: The effects of antihypertensive agents on serum lipids and lipoproteins. Arch Intern Med 1988;148:1280-1288.
5. Carlsen JE, Koeber L, Torp-Pedersen C, et al: Relation between dose of bendroflumethiazide, antihypertensive effect, and adverse biochemical effect. Br Med J 1990;300:975-978.
6. Pollare T, Lithell H, Berne C: A comparison of the effects of HCTZ and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J Med 1989;321:868-873.
7. Jounela AJ, Lilja M, Lumme J, et al: Relation between low dose of HCTZ, antihypertensive effect and adverse effects. Blood Press 1994;3:231-235.
8. Guul SJ, Os I, Jounela AJ: The efficacy and tolerability of enalapril in formulation with a very low dose of hydrochlorothiazide in hypertensive patients resistent to enalapril monotherapy. Am J Hypertens 1995;8:727-731.
9. Andren L, Weiner L, Svensson A, et al: Enalapril with either a "very low" or "low" dose of HCTZ is equally ineffective on essential hypertension. A double blind trial in 100 hypertensive patients. J Hypertens 1983; 1(suppl 3):384-386.
10. Canadian Enalapril Study Group: Comparison of monotherapy with enalapril and atenolol in mild to moderate hypertension. Can Med Assoc J 1987;137:803-808.
11. Steiner SS, Friedhoff AJ, Wilson BL, et al: Antihypertensive therapy and quality of life: a comparison of atenolol, captopril, enalapril and propranolol. J Hum Hypertens 1990;4:217-225.
12. Helgeland A, Strømmen R, Hagelund CH, Tretiti S: Enalapril, atenolol and hydrochlorothiazide in mild to moderate hypertension: a comparative multicenter study in general practice in Norway. Lancet 1986;1:872-875.
13. Gabriel MA, Tsianco MC, Kramsch DM, Moncloa F: Once-a-day enalapril compared with atenolol in hypertension. Clin Pharmacol Ther 1985;37:198.
14. Webster J, Petrie JC, Robb OJ, et al: Enalapril in moderate to severe hypertension: a comparison to atenolol. Br J Clin Pharmacol 1986;21:489-495.
15. Slater EE, Merrill DD, Guess HA, et al: Clinical profile of angioedema associated with angiotensin converting enzyme inhibition. JAMA 1988;260:967-970.