L-arginine deficiency causes suppression of nonadrenergic noncholinergic nerve-mediated smooth muscle relaxation: Role of L-citrulline recycling

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 1, 1997, Pages 378-384

  Chakder, Sushanta ^a   Rattan, Satish ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE; ARGININE; CITRULLINE; GLUTAMIC ACID; GLUTAMINE; N(G) HYDROXYARGININE;

ANIMAL TISSUE; ANUS SPHINCTER; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; FEMALE; MALE; MUSCLE ISOMETRIC CONTRACTION; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; RECTUM; SMOOTH MUSCLE RELAXATION;

ANAL CANAL; ANIMALS; ARGINASE; ARGININE; CITRULLINE; ELECTRIC STIMULATION; FEMALE; GLUTAMINE; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; OPOSSUMS;

EID: 0030819109     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. ANAND, N. AND PATERSON, W. G.: Role of nitric oxide in esophageal peristalsis. Am. J. Physiol. Gastrointest. Liver Physiol. 266: G123-G131, 1994.
2. BIANCANI, P., WALSH, J. H. AND BEHAR, J.: Vasoactive intestinal polypeptide: A neurotransmitter for relaxation of the rabbit internal anal sphincter. Gastroenterology 89: 867-874, 1985.
3. g-Nitro-L-arginine reduces nonadrenergic, noncholinergic relaxations of human gut. Gastroenterology 102: 679-683, 1992.
4. BUSH, P. A., GONZALEZ, N. E. AND IGNARRO, L. J.: Biosynthesis of nitric oxide and citrulline from 1-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. Biochem. Biophys. Res. Commun. 186: 308-314, 1992.
5. GOLD, M. E., BUSH, P. A. AND IGNARRO, L. J.: Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. Biochem. Biophys. Res. Commun. 164: 714-721, 1989.
6. GOYAL, R. K. AND HIRANO, I.: The enteric nervous system. N. Engl. J. Med. 334: 1106-1115, 1996.
7. G-hydroxy-L-arginine in alveolar macrophages: Implications for the utilization of L-arginine for nitric oxide synthesis. FEBS Lett. 359: 251-254, 1995.
8. JAFFREY, S. R. AND SNYDER, S. H.: Nitric oxide: A neural messenger. Annu. Rev. Cell Biol. 11: 417-440, 1995.
9. KNUDSEN, M. A., GLAVIND, E. B. AND TOTTRUP, A.: Transmitter interactions in rabbit internal anal sphincter. Am. J. Physiol. Gastrointest. Liver Physiol. 269: G232-G239, 1995.
10. KONTUREK, J. W., GILLESSEN, A. AND DOMSCHKE, W.: Diffuse esophageal spasm: A malfunction that involves nitric oxide? Scand. J. Gastroenterol. 30: 1041-1045, 1995.
11. LEE, T. J. F., SARWINSKI, S., ISHINE, T., LAI, C. C. AND CHEN, F. Y.: Inhibition of cerebral neurogenic vasodilation by L-glutamine and nitric oxide synthase inhibitors and its reversal by L-citrulline. J. Pharmacol. Exp. Ther. 276: 353-358, 1996.
12. LOWRY, O. H., ROSENBROUGH, N. J., FARR, A. L. AND RANDALL, R. J.: Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
13. MAKHLOUF, G. M. AND GRIDER, J. R.: Nonadrenergic noncholinergic inhibitory neurotransmitters of the gut. News Physiol. Sci. 8: 195-199, 1993.
14. MONCADA, S., PALMER, R. M. J. AND HIGGS, E. A.: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
15. MONCADA, S. AND HIGGS, A.: Mechanisms of disease: The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329: 2002-2012, 1993.
16. MOUMMI, C. AND RATTAN, S.: Effect of methylene blue and N-ethylmaleimide on internal anal sphincter relaxation. Am. J. Physiol. 255: G571-G578, 1988.
17. MURRAY, J., DU, C., LEDLOW, A., BATES, J. N. AND CONKLIN, J. L.: Nitric oxide: Mediator of nonadrenergic noncholinergic responses of opossum esophageal muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 261: G401-G406, 1991.
18. NURKO, S. AND RATTAN, S.: Role of vasoactive intestinal polypeptide in the internal anal sphincter relaxation of the opossum. J. Clin. Invest. 81: 1146-1153, 1988.
19. O'KELLY, T., BRADING, A. AND MOHTENSEN, N.: Nerve mediated relaxation of the human internal anal sphincter: The role of nitric oxide. Gut 34: 689-693, 1993.
20. RAE, M. G. AND MUIR, T. C.: Neuronal mediators of inhibitory junction potentials and relaxation in the guinea-pig internal anal sphincter. J. Physiol. (Lond.) 493: 517-527, 1996.
21. RATTAN, S., MOUMMI, C. AND CHAKDER, S.: CGRP and ANF cause relaxation of opossum internal anal sphincter via different mechanisms. Am. J. Physiol. Gastrointest. Liver Physiol. 260: G764-G769, 1991.
22. RATTAN, S. AND CHAKDER, S.: Role of nitric oxide as a mediator of internal anal sphincter relaxation. Am. J. Physiol. Gastrointest. Liver Physiol. 262: G107-G112, 1992.
23. RATTAN, S., SARKAR, A. AND CHAKDER, S.: Nitric oxide pathway in rectoanal inhibitory reflex of opossum internal anal sphincter. Gastroenterology 103: 43-50, 1992.
24. RATTAN, S. AND CHAKDER, S.: Inhibitory effect of CO on internal anal sphincter: Heme oxygenase inhibitor inhibits NANC relaxation. Am. J. Physiol. Gastrointest. Liver Physiol. 265: G799-G804, 1993.
25. RATTAN, S., MORI, M., BANDYOPADHYAY, A. AND CHAKDER, S.: Evidence for L-citrulline recycling being responsible for the maintenance of internal anal sphincter (IAS) relaxation by nonadrenergic noncholinergic (NANC) nerve stimulation (Abstract). Gastroenterology 110: A742, 1996.
26. SANDERS, K. M. AND WARD, S. M.: Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am. J. Physiol. Gastrointest. Liver Physiol. 262: G379-G392, 1992.
27. SESSA, W. C., HECKER, M., MITCHELL, J. A. AND VAKE, J. R.: The metabolism of 1-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 87: 8607-8611, 1990.
28. SHUTTLEWORTH, C. W. R., BURNS, A. J., WARD, S. M., O'BRIEN, W. E. AND SANDERS, K. M.: Recycling of L-citrulline to sustain nitric oxide-dependent enteric neurotransmission. Neuroscience 68: 1295-1304, 1995.
29. STARK, M. E. AND SZURSZEWSKI, J. H.: Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology 103: 1928-1949, 1992.
30. TOTTRUP, A., GLAVIND, E. B. AND SVANE, D.: Involvement of the L-arginine-nitric oxide pathway in internal anal sphincter relaxation. Gastroenterology 102: 409-415, 1992.
31. TOTTRUP, A., KNUDSEN, M. A., SORENSEN, F. H. AND GLAVIND, E. B.: Pharmacological identification of different inhibitory mediators involved in the innervation of the internal anal sphincter. Br. J. Pharmacol. 115: 158-162, 1995.
32. YAMATO, S., SPECHLER, S. J. AND GOYAL, R. K: Role of nitric oxide in esophageal peristalsis in the opossum. Gastroenterology 103: 197-204, 1992.
33. YU, Y., TERADA, K., NAGASAKI, A., TAKIGUCHI, M. AND MORI, M.: Preparation of recombinant argininosuccinate synthetase and argininosuccinate lyase: Expression of the enzymes in rat tissues. J. Biochem. (Tokyo) 117: 952-957, 1995.