Endogenous and exogenous regulation of redox-properties of coenzyme Q

Molecular Aspects of Medicine

Volumn 18, Issue SUPPL., 1997, Pages 33-40

  Nohl, H ^a   Gille, L ^a   Staniek, K ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

Coenzyme Q; Dihydrolipoic acid; ESR; Lipid peroxidation; Liposomes

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; DIHYDROLIPOATE; LOW DENSITY LIPOPROTEIN; UBIQUINONE;

ANTIOXIDANT ACTIVITY; AUTOOXIDATION; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENERGY METABOLISM; LIPID BILAYER; LIPID PEROXIDATION; MITOCHONDRIAL ENERGY TRANSFER; OXIDATION REDUCTION REACTION; RESPIRATORY CHAIN;

EID: 0030819021     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0098-2997(97)00020-4     Document Type: Conference Paper

References (23)

1. Anusevicius, Z. J. and Cenas, N. K. (1993). Dihydrolipoamide-mediated redox cycling of quinones. Archives of Biochemistry and Biophysics, 302, 420-424.
2. Babbs, C. F. and Steiner, M. G. (1990). Simulation of free radical reactions in biology and medicine: a new two compartment kinetic model of intracellular lipid peroxidation. Free Radicals in Biology and Medicine, 8, 171-185.
3. Cadenas, E., Boveris, A., Ragan, C. I. and Stoppani, A. O. M. (1977). Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef heart mitochondria Archives of Biochemistry and Biophysics, 180, 248-257.
4. Ellman, G. L. (1959). Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 82, 70-77.
5. Esterbauer, H., Gebicki, J., Puhl, H. and Juergens, G. (1992). The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radicals in Biology and Medicine, 13, 341-390.
6. Janzen, E. G., Krygsman, P. H., Lindsay, D. A. and Haire, D. L. (1990). Detection of alkyl, alkoxyl, and alkyperoxyl radicals from the thermolysis of azobis(isobutyronitrile) by ESR/spin trapping. Evidence for double spin adducts from liquid-phase chromatography and mass spectroscopy. Journal of the American Chemistry Society, 112, 8279-8284.
7. Kagan, V., Serbinova, E. and Packer, L. (1990). Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochemical and Biophysical Research Communications, 169, 851-857.
8. Kagan, V. E., Shvedova, A., Serbinova, E., Khan, S., Swanson, C., Powell, R. and Packer, L. (1992). Dihydrolipoic acid - A universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochemical Pharmacology, 44, 1637-1649.
9. Konstantinov, A. A., Peskin, A. V., Popova, E. Yu., Khomutov, G. B. and Ruuge, E. K. (1987). Superoxide generation by the respiratory chain of tumor mitochondria. Biochimica Biophysica Acta, 894, 1-10.
10. Kroeger, A. (1978) Determination of contents and redox states of ubiquinone and menaquinone. In Methods in Enzymology Vol. LIII (S. Fleischer and L. Packer, eds), pp. 573-591. Academic Press, New York.
11. Maguire, J. J., Kagan, V., Ackrell, B. A. C., Serbinova, E. and Packer, L. (1992). Succinate ubiquinone reductase linked recycling of alpha-tocopherol in reconstituted systems and mitochondria: requirement for reduced ubiquinone. Archives of Biochemistry and Biophysics, 292, 47-53.
12. -. quinone binding site from the protein surface of the cytochrome bel complex in Rhodobacter capsulates chromatophores. Biochimica Biophysica Acta, 1100, 67-74.
13. Molin, Y. N., Sahlikhov, K. M., and Zamaraev, K. I. (1980) Spin Exchange (Springer Series in Chemical Physics; Vol. 8). Springer, Heidelberg.
14. Mukai, K., Kikuchi, S. and Urano, S. (1990). Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution. Biochimica Biophysica Acta, 1035, 77-83.
15. Mukai, K., Morimoto, H., Kikuchi, S. and Nagaoka, S. (1993). Kinetic study of free radical scavenging action of biological hydroquinones (reduced forms of ubiquinone, vitamin K and tocopherolquinone) in solution. Biochimica Biophysica Acta, 1157, 313-317.
16. Nohl, H. (1986) Oxygen radical release in mitochondria: influence of age. In Modern Aging Research, Vol. 8; Free Radicals, Aging and Degenerative Diseases (J. E. Johnson, D. Harman, R. Walford and J. Miquel, eds), pp. 77-97. A. R. Liss, New York.
17. Nohl, H. and Stolze, K. (1992). Ubisemiquinones of the mitochondrial respiratory chain do not interact with molecular oxygen. Free Radical Research Communications, 16, 409-419.
18. Nohl, H., Gille, L., Schoenheit, K. and Liu, Y. (1996). Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox couple with molecular oxygen. Free Radicals in Biology and Medicine, 20, 207-213.
19. Rauchova, H., Drahota, Z. and Lenaz, G. (1995). Function of coenzyme Q in the cell: some biochemical and physiological properties. Physiology Research, 44, 209-216.
20. Stolze, K. and Nohl, H. (1993). The effect of xenobiotics on the respiratory activity of rat heart mitochondria and the concomitant formation of superoxide radicals. Environmental Toxicology and Chemistry, 13, 499-502.
21. Suzuki, Y. J., Tsuchiya, M. and Packer, L. (1993). Antioxidant activities of dihydrolipoic acid and its structural homologues. Free Radical Research Communication, 18, 115-122.
22. Thomas, S. R., Neuzil, J. and Stocker, R. (1996). Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation. Arteriosclerosis Thrombosis and Vascular Biology, 16, 687-696.
23. Urban, P. F. and Klingenberg, M. (1969). On the redox potentials of ubiquinone and cytochrome b in the respiratory chain. European Journal of Biochemistry, 9, 519-525.