The use of precision-cut rat lung slices for studying PGF(2α) metabolism

Environmental Toxicology and Pharmacology

Volumn 3, Issue 4, 1997, Pages 251-256

  Madhu, Cherukury ^a   Rix, Peter ^a   Small, David ^a   Yuan, Yang Dar ^a   Tang Liu, Diane D S ^a  

^a ALLERGAN INC   (United States)

Author keywords

Lung slices; Metabolism; Prostaglandin F(2 ); Rat

Indexed keywords

PROSTAGLANDIN F2 ALPHA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG SLICE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030818535     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(97)00020-3     Document Type: Article

References (16)

1. Azri, S., Mata, H.P., Reid, L.L., Gandolfi, A.J., 1990. Further examination of the selective toxicology of CC14 in rat liver slices. Toxicol. Appl. Pharmacol. 112, 81.
2. Beamand, J.A., Price, R.J., Blowers, S.D., Wield, P.T., Cunningham, M.E., Lake, B.G., 1994. Use of precision-cut liver slices for studies of unscheduled DNA synthesis. Food Chem. Toxicol. 32, 819.
3. 2α, metabolism by human ocular tissues. Invest. Ophthalmol. Vis. Sci. 25, 1087.
4. Fisher, R.L., Smith, M.S., Hasal, S.J., Hasal, K.S., Gandolfi, A.J., Brendal, K., 1994. The use of human lung slices in toxicology. Hum. Exp. Toxicol. 13, 466.
5. 2α in female subjects. J. Biol. Chem 246, 7470.
6. Guengerich, F.P., 1990. Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue. Pharmcol. Ther. 45, 299.
7. Granstrom, E., Kindahl, H., 1982. Species differences in circulating prostaglandin metabolites; relevance for the assay of prostaglandin release. Biochim. Biophys. Acta. 713, 555-569.
8. Granstrom, E., Kindahl, H., Swahn, M.L., 1982. Profiles of prostaglandin metabolites in the human circulation identification of late-appearing, long-lived products. Biochim. Biophys. Acta. 713, 46.
9. Hanss, G.J., Taylor, G.W., 1993. Metabolism and toxicology of the prostaglandins. In: Vane, J.R., O'Grady, J. (Eds.), Therapeutic application of prostaglandins, Edward Arnold, London, pp. 37-48.
10. Lake, B.G., Beamand, J.A., Japenga, A.C., Renwick, A., Davies, S., Price, R.J., 1993. Induction of cytochrome P-450-dependent enzyme activities in cultured rat. Food Chem. Toxicol. 31, 377.
11. Pace-Asciak, C., Miller, D., 1973. Prostaglandins during development. I. Age-dependent activity profiles of prostaglandin 15-hydroxydehydrogenase and 13,14-reductase in lung tissue from late prenatal, early postnatal and adult rats. Prostaglandins 4, 351.
12. Poet, S.T., Brendal, K., Halpert, J.R., 1994. Inactivation of cytochrome P450 2B protects against cocaine-mediated toxicity in rat liver slices. Toxicol. Appl. Pharmacol. 126, 26.
13. Powell, W.S., 1978. ω-Oxidation of prostaglandins by lung and liver microsomes. J. Biol. Chem. 253, 6711.
14. Steensma, A., Beamand, J.A., Walters, D.G., Price, R.J., Lake, B.G., 1994. Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices. Xenobiotica 24, 893.
15. Stefaniak, M.S., Krumdiek, C.L., Spall, R.Da., Gandolfi, J., Brendel, K., 1992. Biochemical and histological characterization of agar-filled precision-cut rat lung slices in dynamic organ culture as an in vitro tool. In Vitro Toxicol. 5, 7.
16. 2 and its subsequent metabolism in rat, rabbit and guinea pig. Biochem. Pharmacol. 37, 3591.