Optimization of a new filler/binder for direct compression using central composite design

Drug Development and Industrial Pharmacy

Volumn 23, Issue 10, 1997, Pages 945-950

  Cirunay, Jesusa Joyce N ^a   Plaizier Vercammen, Jacqueline A ^a  

^a PHARMACEUTICAL INSTITUTE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ASAGRAN; CARBOXYMETHYLCELLULOSE; FILLER; UNCLASSIFIED DRUG; XYLITAB 200; XYLITOL;

ARTICLE; TABLET COMPRESSION;

EID: 0030818394     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.3109/03639049709149145     Document Type: Article

References (13)

1. D. E. Fonner Jr, J. R. Buck, and G. S. Banker, J. Pharm. Sci. 59, 1587 (1970).
2. D. A Doornbos, Pharm. Weekbl. [Sci], 3, 549 (1981).
3. R. Huisman, H. V. Van Kamp, J. W. Weyland, D. A Doornbos, G. K. Bolhuis, and C. F. Lerk, Pharm. Weekbl. [Sci], 6, 185 (1984).
4. J. H. De Boer, A. K. Smilde, and D. A. Doornbos, Acta Pharm. Technol., 34, 140 (1988).
5. J. B. Schwartz, J. R. Flamholtz, and R. H. Press, J. Pharm. Sci. 6, 1165 (1973).
6. H. A. Lieberman, M. M. Rieger, and G. S. Banker, Pharmaceutical Dosage Forms-Disperse Systems, Vol. 1, Marcel Dekker, New York, 1988, pp. 438-464.
7. J. J. N. Cirunay and J. Plaizier-Vercammen, Evaluation of a new filler/binder for direct compression using factorial design, accepted for publicaion. Drug. Dev. and Ind. Pharm.
8. Directly Compressible Xylitab® Brochure 1991, Xyrofin, Finland.
9. European Pharmacopoeia 2nd ed., European Department for the Quality of Medicines with the Council of Europe, F67029 Strasbourg, pp. V.5.1.1.
10. US Pharmacopoeia, 21st rev; US Pharmacopeial Convention, Rockville, MD, 1985, pp. 78, 1243-1244.
11. G. E. P. Box, W. G. Hunter, and J. S. Hunter, Statistics for Experimenters, Wiley, New York, 1978; pp. 307-351.
12. SPSS for Windows, Release 5.0.1.
13. N. R. Draper and H. Smith, Applied Regression Analysis, 2nd ed., Wiley, New York, 1981.