Antithrombotic effects of KBT-3022, a novel antiplatelet agent, in an arterial thrombosis model in the guinea-pig

Drug Development Research

Volumn 40, Issue 3, 1997, Pages 217-222

  Shimazawa, Masamitsu ^a,c   Takiguchi, Yoshiharu ^a,b   Umemura, Kazuo ^a   Nakashima, Mitsuyoshi ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c KANEBO LTD   (Japan)

Author keywords

Acetylsalicylic acid; Cyclooxygenase inhibitor; Ticlopidine

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; PAMICOGREL; TICLOPIDINE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GUINEA PIG; IN VITRO STUDY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; THROMBOCYTE AGGREGATION; THROMBOSIS;

EID: 0030818145     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199703)40:3<217::AID-DDR1>3.0.CO;2-N     Document Type: Article

References (14)

1. Ashida S, Abiko Y (1979): Mode of action of ticlopidine in inhibition of platelet aggregation in the rat. Thromb Haemost 41:436-449.
2. Burke SE, Lefer AM, Nicolaou KC, Smith GM, Smith B (1983): Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues. Br J Pharmacol 78:287-292.
3. Gabriel SE, Jaakkimainen L, Bombardier C (1991): Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: A meta-analysis. Ann Intern Med 115:787.
4. Gandin E, Lion Y, Van de Dorst A (1983): Quantum yield of singlet oxygene production by xanthine derivatives. Photochem Photobiol 37:271-278.
5. Graham DY (1990): The relationship between nonsteroidal anti-inflammatory drug use and peptic ulcer disease. Gastroenterol Clin North Am 19:171.
6. Gralnick HR, Kramer WS, McKeown LP, Garfinkel L, Pinot A, Williams SB, Krutzsch H (1996): Platelet adhesion at high shear rates: The roles of von Willebrand factor/GPIb and the β1 integrin α2β1. Thromb Res 81:113-119.
7. 2, ADP and thrombin in thrombogenesis in the guinea pig. Eur J Pharmacol 231:421-425.
8. 2 pathway in intravascular platelet aggregation in guinea-pigs and rats. Br J Pharmacol 84:425.
9. Roth GJ, Calverley DC (1994): Aspirin, platelets, and thrombosis: Theory and practice. Blood 83:885-898.
10. Takiguchi Y, Hirata Y, Wada K, Nakashima M (1992): Arterial thrombosis model with photochemical reaction in guinea-pig and its property. Thromb Res 67:435-445.
11. Yamamoto N, Yokota K, Yamashita A, Oda M (1995): The effects of KBT-3022, a new anti-platelet agent, on hemorheological properties in guinea pigs. Thromb Haemost 73:118-121.
12. Yamashita A, Matsuo K, Yokota K, Ito K, Nurimoto S (1990): Anti-platelet effect and mode of action of a new anti-platelet agent KBT-3022. Eur J Pharmacol 183:340.
13. Yokota K, Yamamoto N, Morimoto Y, Yamashita A, Oda M (1995a): Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functions. J Pharm Pharmacol 47:768-774.
14. Yokota K, Yamashita A, Oda M (1995b): Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis. Jpn J Pharmacol 68:201-206.