Novel dithiocarbamate carbapenems with anti-MRSA activity

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 13, 1997, Pages 1617-1622

  Ohtake, Norikazu ^a   Imamura, Hideaki ^a   Kiyonaga, Hideo ^a   Jona, Hideki ^a   Ogawa, Masayuki ^a   Okada, Shigemitsu ^a   Shimizu, Aya ^a   Moriya, Minoru ^a   Sato, Hiroki ^a   Tominaga, Yushin ^a   Yamada, Koji ^a   Nakano, Masato ^a   Ushijima, Ryosuke ^a   Nakagawa, Susumu ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM DERIVATIVE; DITHIOCARBAMIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; SEPTICEMIA;

EID: 0030816304     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00272-2     Document Type: Article

References (15)

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13. The relative hydrolysis rate was determined by using partially purified porcine DHP-I, taking the hydrolysis rate of imipenem as 1.0.
14. 14C]benzylpenicillin using membrane isolated from MRSA BB6294 strain.
15. ICR mice (4 weeks old, male) were infected intraperitonealy with homotypic MRSA BB6221 in 5% gastric mucin. Each agent was administered subcutaneously at Ihr after infections in combination with cilastatin at a dose of 40 mg/kg.