Effect of vitamin E supplementation on prostaglandin concentrations in aspirin-induced acute gastric injury in aged rats

American Journal of Clinical Nutrition

Volumn 66, Issue 5, 1997, Pages 1218-1223

  Stickel, Felix ^a   Meydani, Mohsen ^a   Wu, Dayong ^a   Bronson, Roderick ^a   Martin, Antonio ^a   Smith, Donald ^a   Meydani, Simin Nikbin ^a   Russell, Robert M ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Aging; Aspirin; Gastric injury; Prostaglandins; Rats; Thromboxane; Vitamin E

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTANOID; THROMBOXANE A2;

AGED; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RADIOIMMUNOASSAY; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STOMACH INJURY; SUPPLEMENTATION; VITAMIN BLOOD LEVEL;

EID: 0030815458     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/66.5.1218     Document Type: Article

References (45)

1. Soll AH, Weinstein WM, Kurata J, McCarthy D. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann Intern Med 1991;114:307-19.
2. Allison MC, Howaston AG, Torrance CJ, Lee FD, Russell EI. Gastrointestinal damage associated with the use of nonsteroidal anti-inflammatory drugs. N Engl J Med 1992;327:749-54.
3. Bjarnason I, Hayllar J, MacPherson AJ, Russell AS. Side effects of nonsteroidal anti-inflammatory drugs in the small and large intestine in humans. Gastroenterology 1993;104:1832-47.
4. Schoen RT, Vender RJ. Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage. Am J Med 1989;86:449-58.
5. Cryer B, Feldman M. Effects of nonsteroidal anti-inflammatory drugs on endogenous gastrointestinal prostaglandins and therapeutic strategies for prevention and treatment of nonsteroidal anti-inflammatory drug-induced damage. Arch Intern Med 1992;152:1145-52.
6. Eberhart CE, Dubois RN. Eicosanoids and the gastrointestinal tract. Gastroenterology 1995;109:285-301.
7. Somerville K, Faulkner G, Langman MJ. Nonsteroidal anti-inflammatory drugs and bleeding peptic ulcers. Lancet 1986;1:462-4.
8. Beard K, Walter AM, Perera DR, Jick H. Nonsteroidal anti-inflammatory drugs and hospitalization for gastroesophageal bleeding in the elderly. Arch Intern Med 1987;147:1621-3.
9. Faulkner G, Pritchard P, Somerville K, Langman MJ. Aspirin and bleeding peptic ulcer in the elderly. Br J Med 1988;297:1311-3.
10. Cryer B, Redfern JS, Goldschmidt M, Lee E, Feldman M. Effects of aging on gastric and duodenal mucosal prostaglandin concentrations in humans. Gastroenterology 1992;102:1118-23.
11. Goto H, Tsukamoto Y, Kuroiwa M, Ohara A, Hoshino H, Segawa H. Effects of aging of gastric mucosal prostaglandins. Gastroenterology 1991;100:A74(abstr).
12. Greenberg RE, Bank S, Kranz V. Effect of aging on aspirin-induced inhibition of gastric mucosal prostaglandins. Gastroenterology 1989;96:A163 (abstr).
13. Bank S, Greenberg RE, Kranz V, Ilardi C. The influence of aging on gastric mucosal prostaglandins. Dig Dis Sci 1988;33:898.
14. 2 levels in rats. Dig Dis Sci 1990;35:80-5.
15. Lee M, Feldman M. Age-related reductions in gastric mucosal prostaglandin levels increase susceptibility to aspirin-induced injury in rats. Gastroenterology 1994;107:1746-50.
16. 2 in rabbit. Prostaglandins Leukot Med 1982;9:373-6.
17. Gilbert VA, Zebrowsky EJ, Chan AC. Differential effect of megavitamin E on prostacyclin and thromboxane synthesis in streptozocin-induced diabetic rats. Horm Metab Res 1983;15:320-4.
18. 2 production by macrophages. Nutr Cancer 1993;20:205-14.
19. 2 production in macrophages from vitamin E-treated rats. Prostaglandins Leukot Essent Fatty Acids 1991;44:89-92.
20. 2 production in rat peritoneal macrophages. Biochim Biophys Acta 1991;1074:251-5.
21. Beharka AA, Wu D, Han SN, Meydani SN. Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by dietary antioxidants. Mech Ageing Dev 1997;93:59-77.
22. Meydani SN, Barklund PM, Liu S, et al. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 1990;52:557-63.
23. 2 and aortic prostacyclin synthesis in rats. Nutr Biochem 1993;4:322-6.
24. Tengerdy RP, Mathias MM, Nockels CF. Effects of vitamin E on immunity and disease resistance. In: Prasad A, ed. Vitamins, nutrition, and cancer. Basel, Switzerland: Karger, 1986:123-33.
25. Meydani M. Vitamin E. Lancet 1995;345:170-5.
26. Reeves PG, Nielsen FH, Fancy GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee in the reformulation of the AIN-76A rodent diet. J Nutr 1993;123:1939-51.
27. Lanza FL, Royer GL, Nelson RS. Endoscopic evaluation of the effect of aspirin, buffered aspirin, and enteric-coated aspirin on gastric and duodenal mucosa. N Engl J Med 1980;303:136-8.
28. Hwang DH, Mathias MM, Dupont J, Meyer DL. Linoleate enrichment of diet and prostaglandin metabolism in rats. J Nutr 1976;105:995-1002.
29. 2a in unextracted plasma, serum, and myocardium. Prostaglandins 1976;12:472-86.
30. Hayek MG, Meydani SN, Meydani M, Blumberg JB. Age differences in eicosanoid production of mouse splenocytes: effects on mitogen-induced T-cell proliferation. J Gerontol 1994;49:B197-207.
31. Meydani SN, Dupont J. Effect of zinc deficiency on prostaglandin levels in different organs of the rat. J Nutr 1982;112:1098-104.
32. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
33. Brodie DA, Hooke KF. Effects of route of administration on the production of gastric hemorrhage in rats by aspirin and sodium salicylate. Am J Dig Dis 1971;16:985-8.
34. Konturek SI, Piastucki I, Brzozowski T, et al. Role of prostaglandins in the formation of aspirin-induced gastric ulcers. Gastroenterology 1981;80:4-9.
35. Ligumsky M, Golanska E, Hansen DG, Kauffman GL. Aspirin can inhibit gastric mucosal cyclooxygenase without causing lesions in rats. Gastroenterology 1983;84:756-61.
36. Azuumi Y, Ohara S, Ishihara K, Okabe H, Hotta K. Correlation of quantitative changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats. Gut 1980;21:533-6.
37. Lee M, Feldman M. Non-essential role of leukotrienes as mediators of acute gastric mucosal injury induced by aspirin in rats. Dig Dis Sci 1992;37:1282-7.
38. Weindruch RH, Kristie JA, Kay E, Cheney P, Walford RL. Influence of controlled dietary restriction on immunologieal function and aging. Fed Proc Sci 1979;38:2007-16.
39. Fernandes G. Effect of dietary fish oil supplement on autoimmune disease: changes in lymphoid cell subsets, oncogene mRNA expression and neuroendocrine hormones. In: Chandra RK, ed. Health effect of fish and fish oils. St John's, Newfoundland, Canada: ARTS Biomedical Publishers and Distributors, 1989:409-33.
40. Corvin LM, Schloss H. Role of antioxidants on the stimulation of the mitogenic response. J Nutr 1980;110:2497-505.
41. Hwang DH, Donovan J. In vitro and in vivo effect of vitamin E on arachidonic acid metabolism in rat platelets. J Nutr 1982;112:1233-7.
42. Toivanen JL. Effects of selenium, vitamin E, and vitamin C on human prostacyclin and thromboxane synthesis in humans. Prostaglandins Leukot Med 1987;26:265-80.
43. Ali M, Gudbranson G, McDonald JWD. Inhibition of human platelet cyclooxygenase by α-tocopherol. Prostaglandins Med 1980;4:79-85.
44. Tengerdy RP. Effect of vitamin E on immune responses. Basic Clin Nutr 1980;1:429-45.
45. 1a by the gastric mucosa of several species. J Physiol 1978;275:4P-5P.