Vigabatrin in refractory childhood epilepsy. The Brazilian multicenter study

Epilepsy Research

Volumn 29, Issue 1, 1997, Pages 1-6

  Gherpelli, J L D ^a   Guerreiro, M M ^b   Da Costa, J C ^c   Rotta, N T ^d   Manreza, M L G ^a   Reed, U C ^a   Diament, A ^a   Silva, E A ^b   Guerreiro, C A M ^b   Nunes, M L ^c   Palmini, A ^c   Vega Gutierrez L ^c   Vizioli, J ^d   Pedroso, F ^d   Chiste M A ^d  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Antiepileptic drugs; Childhood epilepsy; Refractory epilepsy; Vigabatrin

Indexed keywords

CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; DIAZEPAM; LAMOTRIGINE; LORAZEPAM; NITRAZEPAM; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; VALPROIC ACID; VIGABATRIN;

ADOLESCENT; ADULT; ANTICONVULSANT ACTIVITY; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CLONIC SEIZURE; COMPLEX PARTIAL SEIZURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GASTROINTESTINAL SYMPTOM; GRAND MAL EPILEPSY; HUMAN; HYPERACTIVITY; IRRITABILITY; MALE; MYOCLONUS SEIZURE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SOMNOLENCE; TONIC SEIZURE; VERTIGO;

ADOLESCENT; ANTICONVULSANTS; BRAZIL; CHILD; CHILD, PRESCHOOL; EPILEPSIES, PARTIAL; EPILEPSY, GENERALIZED; FEMALE; FOLLOW-UP STUDIES; GAMMA-AMINOBUTYRIC ACID; HUMANS; INFANT; MALE; PROSPECTIVE STUDIES; VIGABATRIN;

EID: 0030815347     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(97)00052-1     Document Type: Article

References (16)

1. Riekkinen P.J., Pitkanen A., Ylinen A., Sivenius J., Halonen T. Specificity of vigabatrin for GABAergic system in human epilepsy. Epilepsia. 30(Suppl 3):1989;S18-S22.
2. Schechter P.J. Biochemical and therapeutic effect of GABA-transferase inhibition: clinical studies with gamma-vynil GABA. Neuropharmacology. 23:1984;865-866.
3. Gram L., Blatt Lyon B., Dam M. Gamma-vynil GABA: a single trial in patients with epilepsy. Acta Neurol Scand. 68:1983;34-39.
4. Matilainen R., Pitkänen A., Ruutiainen T., Mervaala E., Sarlund H., Riekkinen P. Effect of vigabatrin on epilepsy in mentally retarded patients. Neurology. 38:1988;743-747.
5. Pitkänen A., Ylinen A., Matilainen R., Luukkainen R., Mervaala E., Seppänen R., Ruutiainen T., Riekkinen P.J. Long-term antiepileptic efficacy of vigabatrin in drug-refractory epilepsy in mentally retarded patients. Arch Neurol. 50:1993;224-229.
6. Reynolds E.H., Ring H.A., Farr I.N., Heller A.J., Elwes R.D.C. Open, double-blind and long-term study of vigabatrin in chronic epilepsy. Epilepsia. 32:1991;530-538.
7. Sivenius J., Ylinen A., Murros K., Mumford J.P., Riekkinen P.J. Vigabatrin in drug-resistant partial epilepsy. Neurology. 41:1991;562-565.
8. Livingston J.H., Beaumont D., Arzimanoglou A., Aicardi J. Vigabatrin in the treatment of epilepsy in children. Br J Clin Pharmacol. 27(Suppl 1):1989;109S-112S.
9. Luna D., Dulac O., Pajot N., Beaumont D. Vigabatrin in the treatment of childhood epilepsies: a single blind placebo controlled study. Epilepsia. 30:1989;430-437.
10. Dulac O., Chiron C., Luna D., Cusmai R., Pajot N., Beaumont D., Mondragon S. Vigabatrin in childhood epilepsy. J Child Neurol. 6(Suppl 2):1991;S30-S37.
11. Appleton R.E. The role of vigabatrin in the management of infantile epileptic syndromes. Neurology. 43(Suppl 5):1993;S21-S23.
12. Vles J.S., van der Heyden A.M., Ghijs A., Troost J. Vigabatrin in the treatment of infantile spasms. Neuropediatrics. 24:1993;230-231.
13. Gibbs J.M., Appleton R.E., Rosenbloom L. Vigabatrin in intractable childhood epilepsy: a retrospective study. Pediatr Neurol. 8:1992;338-340.
14. Uldall P., Alving J., Gram L., Beck S. Vigabatrin in pediatric epilepsy - an open study. J Child Neurol. 6(Suppl 2):1991;S38-S44.
15. Fois A., Buoni S., Di Bartolo R.M., Di Marco V., Mostardini R. Vigabatrin treatment in children. Child's Nerv Syst. 10:1994;244-248.
16. Herranz J.L., Arteaga R., Farr I.N., Valdizan E., Beaumont D., Armijo J.A. Dose-response study of vigabatrin in children with refractory epilepsy. J Child Neurol. 6(Suppl 2):1991;S45-S51.