Lif, the lysostaphin immunity factor, complements FemB in staphylococcal peptidoglycan interpeptide bridge formation

FEMS Microbiology Letters

Volumn 153, Issue 2, 1997, Pages 261-264

  Tschierske, M ^a   Ehlert, K ^b   Stranden A M ^a   Berger Bachi B ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b BAYER AG   (Germany)

Author keywords

Lysostaphin immunity factor; Methicillin resistance; Peptidoglycan; Staphylococcus aureus

Indexed keywords

LYSOSTAPHIN; PEPTIDOGLYCAN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; ENZYME ACTIVITY; PENICILLIN RESISTANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; STAPHYLOCOCCUS AUREUS;

AMINO ACIDS; BACTERIAL PROTEINS; CARRIER PROTEINS; CELL WALL; GENETIC COMPLEMENTATION TEST; GLYCINE; HEXOSYLTRANSFERASES; LYSOSTAPHIN; METHICILLIN RESISTANCE; MULTIENZYME COMPLEXES; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; MUTATION; PENICILLIN-BINDING PROTEINS; PEPTIDOGLYCAN; PEPTIDYL TRANSFERASES; SERINE; STAPHYLOCOCCUS AUREUS;

STAPHYLOCOCCUS AUREUS;

EID: 0030814671     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00234-6     Document Type: Article

References (15)

1. Labischinski, H. (1992) Consequences of the interaction of beta-lactam antibiotics with penicillin binding proteins from sensitive and resistant Staphylococcus aureus strains. Med. Microbiol. Immunol. 181, 241-265.
2. Schneewind, O., Fowler, A. and Faull, K.F. (1995) Structure of the cell wall anchor of surface proteins in Staphylococcus aureus. Science 268, 103-106.
3. Matsuhashi, M., Dietrich, C.P. and Strominger, J.L. (1967) Biosynthesis of the peptidoglycan of bacterial cell walls. The role of soluble ribonucleic acid and of lipid intermediates in glycine incorporation in Staphylococcus aureus. J. Biol. Chem. 242, 3191-3206.
4. Strandén, A.M., Ehlert, K., Labischinski, H. and Berger-Bächi, B. (1997) Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus. J. Bacteriol. 179, 9-16.
5. Alborn, W.E., Hoskins, J.A., Unal, S., Flokowitsch, J.E., Hayes, C.A., Dotzlaf, J.E., Yeh, W.K. and Skatrud, P.L. (1996) Cloning and characterization of femA and femB from Staphylococcus epidermidis. Gene 180, 177-181.
6. Thumm, G. and Götz, F. (1997) Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus. Mol. Microbiol. 23, 1251-1265.
7. Dehart, H.P., Heath, H.E., Heath, L.S., Leblanc, P.A. and Sloan, G.L. (1995) The lysostaphin endopeptidase resistance gene (epr) specifies modification of peptidoglycan cross bridges in Staphylococcus simulans and Staphylococcus aureus. Appl. Environ. Microbiol. 61, 1475-1479.
8. Sugai, M., Fujiwara, T., Akiyama, T., Ohara, M., Komatsuzawa, H., Inoue, S. and Suginaka, H. (1997) Purification and molecular characterization of glycylglycine endopeptidase produced by Staphylococcus capitis epk1. J. Bacteriol. 179, 1193-1202.
9. Simmonds, R.S., Pearson, L., Kennedy, R.C. and Tagg, J.R. (1996) Mode of action of a lysostaphin-like bacteriolytic agent produced by Streptococcus zooepidemicus 4881. Appl. Environ. Microbiol. 62, 4536-4541.
10. De Jonge, B.L.M. and Tomasz, A. (1993) Abnormal peptidoglycan produced in a methicillin-resistant strain of Staphylococcus aureus grown in the presence of methicillin - functional role for penicillin-binding protein-2A in cell wall synthesis. Antimicrob. Agents Chemother. 37, 342-346.
11. Henze, U., Sidow, T., Wecke, J., Labischinski, H. and Berger-Bachi, B. (1993) Influence of femB on methicillin resistance and peptidoglycan metabolism in Staphylococcus aureus. J. Bacteriol. 175, 1612-1620.
12. Kopp, U., Roos, M., Wecke, J. and Labischinski, H. (1996) Staphylococcal peptidoglycan interpeptide bridge biosynthesis: a novel antistaphylococcal target? Microb. Drug Resist. 2, 29-41.
13. Wieland, K.-P., Wieland, B. and Götz, F. (1995) A promoter-screening plasmid and xylose-inducible, glucose-repressible expression vector for Staphylococcus carnosus. Gene 158, 91-96.
14. NCCLS (1997) Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 4th edn; approved standard. NCCLS document M7-A4, Villanova, PA.
15. Baker, C.N., Stocker, S.A., Culver, D.H. and Thornsberry, C. (1991) Comparison of the E-test to agar dilution, broth microdilution, and agar diffusion susceptibility testing techniques by using a special challenge set of bacteria. J. Clin. Microbiol. 29, 533-538.