Clinical significance of selective decline of donor-reactive IL-2-producing T lymphocytes after renal transplantation

Transplant Immunology

Volumn 5, Issue 2, 1997, Pages 89-96

  Beik, A I ^a   Higgins, R M ^a   Lam, F T ^a   Morris, A G ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; HLA DR ANTIGEN; INTERLEUKIN 2;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030814623     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(97)80048-2     Document Type: Article

References (38)

1. Starzl TE, Demetris AJ, Murase N, Thomson AW, Trucco M, Ricordi C. Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Immunol Today 1993; 14: 326-32.
2. Bennett WM. The nephrotoxicity of immunosuppressive drugs. Nephrol Dial Transplant 1996; 11: 1899-901.
3. Starzl TE, Murase N, Demetris AJ, Giorda R, Valdivia L, Trucco M. Drug development and testing in relation to cell migration and chimerism. Transplant Proc 1993; 25: 469-72.
4. Sorof JM, Portale AA, Potter D, DeSantes K, Cowan M. Renal transplantation without chronic immunosuppression after T cell-depleted HLA-mismatched bone marrow transplantation. Transplantation 1995; 59: 1633-35.
5. Reinsmoen NL, Matas AJ. Evidence that improved late renal transplant outcome correlates with the development of in vitro donor antigen-specific hyporeactivity. Transplantation 1993; 55: 1017-23.
6. Starzl TE, Demetris AJ, Trucco M et al. Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation 1993; 55: 1272-77.
7. Herzog W, Zanker B, Irschick E et al. Selective reduction of donor-specific cytotoxic lymphocyte precursors in patients with a well functioning kidney allograft. Transplantation 1987; 43: 384-89.
8. Lantz O, Alard P, Ben Aribia MH et al. Persistence of donor-specific IL-2-secreting cells and cytotoxic T lymphocyte precursors in human kidney transplant recipients evidenced by limiting dilution analysis. J Immunol 1990; 144: 3748-55.
9. Mathew JM, Marsh JW, Susskind B, Mohanakumar T. Analysis of T cell responses in liver allograft : Evidence for deletion of donor-specific cytotoxic T cells in the peripheral circulation. J Clin Invest 1993; 91: 900-906.
10. Alard P, Lantz O, Perrot JY, Chavanel G, Senik A, Charpentier B. A possible role for specific anergy in immunologic hyporeactivity to donor stimulation in human kidney allograft recipients. Transplantation 1993; 55: 277-83.
11. Morris PJ, Dallman M, Wood KJ. Anergy in allogeneic transplantation. Transplant Proc 1993; 25: 281-83.
12. Burlingham WJ, Grailer AP, Fechner JH et al. Microchimerism linked to cytotoxic T lymphocyte functional unresponsiveness (clonal anergy) in a tolerant renal transplant recipient. Transplantation 1995; 59: 1147-55.
13. Duffy BF, Mathew JM, Flye MW, Mohanakumar T. Development of autoantibodies to T cell clonotypic structures in a liver-kidney allograft recipient. Transplantation 1993; 56: 212-16.
14. Pollak R, Fabrega AJ, Vasquez E, Sanchez J, Mulero CB, Williams RH. Measurement of serum-soluble interleukin-2 receptor levels following renal transplantation. Transplantation 1995; 59: 926-27.
15. Burdick JF, Kittur DS. Factors affecting early diagnosis of organ allograft rejection. Transplant Proc 1991; 23: 2047-51.
16. Vaessen LM, Baan CC, Ouwehand AJ et al. Acute rejection in heart transplant patients is associated with the presence of committed donor-specific cytotoxic lymphocytes in the graft but not in the blood. Clin Exp Immunol 1992; 88: 213-19.
17. Eberspacher ML, Otto G, Herfarth C, Kabelitz D. Frequency analysis of donor-reactive cytotoxic T lymphocyte precursors in liver allograft recipients: lack of correlation with clinical outcome. Transplantation 1994; 57: 1746-52.
18. Mestre M, Massip E, Bas J et al. Sequential study of immune mechanisms involved in graft acceptance in kidney transplantation. Transplantation Proceedings 1995; 27: 2371-73.
19. Ouwehand AJ, Baan CC, Roelen DL et al. The detection of cytotoxic T cells with high affinity receptors for donor antigens in the transplanted heart as a prognostic factor for graft rejection. Transplantation 1993; 56: 1223-29.
20. Hall BM. Cells mediating allograft rejection. Transplantation 1991; 51: 1141-51.
21. Bishop DK, Shelby J, Eichwald EJ. Mobilization of T lymphocytes following cardiac transplantation. Transplantation 1992; 53: 849-57.
22. Zanker B, Jooss-Rudiger J, Franz HE, Wagner H, Kabelitz D. Evidence that functional deletion of donor-reactive T lymphocytes in kidney allograft recipients can occur at the level of cytotoxic T cells, IL-2-producing T cells, or both. Transplantation 1993; 56: 628-32.
23. Mason PD, Warrens AN, Lechler RI. Could analysis of helper T cell precursor frequencies be used as a predictive parameter in renal transplantation. Transplant Proc 1995; 27: 230-31.
24. Debruyne LA, Renlund DG, Bishop DK. Evidence that human cardiac allograft acceptance is associated with a decrease in donor-reactive helper T lymphocytes. Transplantation 1995; 59: 778-83.
25. Ghobrial II, Morris AG, Booth LJ. Clinical significance of in vitro donor specific hyporesponsiveness in renal allograft recipients as demonstrated by the MLR. Transplant Int 1994; 7: 420-27.
26. Sharrock CE, Kaminski E, Man S. Limiting dilution analysis of human T cells: a useful clinical tool. Immunol Today 1990; 11: 281-86.
27. Deacock S, Schwarer A, Batchelor R, Goldman J, Lechler R. A rapid limiting dilution assay for measuring frequencies of alloreactive, interleukin-2-producing T cells in humans. J Immunol Methods 1992; 147: 83-92.
28. Orosz CG, Adams PW, Ferguson RM. Frequency of human alloantigen-reactive T lymphocytes: II Method for limiting dilution analysis of alloantigen-reactive helper T cells in human peripheral blood. Transplantation 1987; 43: 718-24.
29. Taswell C. Limiting dilution assays for the determination of immunocompetent cell frequencies: I - data analysis. J Immunol 1981; 126: 1614-19.
30. Strijbosch LW, Does RJ, Buurman WA. Computer aided design and evaluation of limiting and serial dilution experiments. Int J Biomed Comput 1988; 23: 279-90.
31. Solez K, Axelsen RA, Benediktsson H et al. International standardisation of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411-22.
32. Hu H, Robertus M, De Jonge N et al. Reduction of donor-specific cytotoxic T lymphocyte precursors in peripheral blood of allografted heart recipients. Transplantation 1994; 58: 1263-68.
33. Bouma GJ, Meer-Prins EM, Woude FJ, Rood JJ, Claas FH. Relevance of pretransplant donor-specific T cell allorepertoire for human kidney graft survival. Transplantation 1995; 59: 969-76.
34. Reader JA, Burke MM, Counihan P et al. Noninvasive monitoring of human cardiac allograft rejection. Transplantation 1990; 50: 29-33.
35. Schwarer AP, Jiang YZ, Deacock S et al. Comparison of helper and cytotoxic antirecipient T cell frequencies in unrelated bone marrow transplantation. Transplantation 1994; 58: 1198-203.
36. Roosnek E, Hogendijk S, Zawadynski S et al. The frequency of pretransplant donor cytotoxic T cell precursors with anti-host specificity predicts survival of patients transplanted with bone marrow from donors other than HLA-identical siblings. Transplantation 1993; 56: 691-96.
37. Debruyne LA, Ensley RD, Olsen SL et al. Increased frequency of alloantigen-reactive helper T lymphocytes is associated with human cardiac allograft rejection. Transplantation 1993; 56: 722-27.
38. - cells as stimulator cells for limiting dilution analysis of alloreactive IL-2-secreting cells and cytotoxic precursors: comparison of their stimulator capacity and ability to generate specific alloreactivity. J Immunol Methods 1991; 137: 121-32.