NS-105. Cognition enhancer, nootropic agent

Drugs of the Future

Volumn 22, Issue 6, 1997, Pages 639-640

  Graul, A ^a   Tracy, M ^a   Castaner J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FASORACETAM; NOOTROPIC AGENT;

CEREBROVASCULAR DISEASE; COGNITION; DRUG SYNTHESIS; HUMAN; LEARNING; MEMORY; NONHUMAN; SHORT SURVEY;

EID: 0030814475     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1997.022.06.410774     Document Type: Short Survey

References (10)

1. Joseki, S., Nakamura, K., Tomita, T., Oshe, M., Sugiyama, S., Ogasawara, T., Kimura, K. Synthesis and learning and memory enhancing action of a new pyroglutamic acid amide derivative. 108th Annu Meet Pharm Soc Jpn (April 4-7, Hiroshima) 1988, Abst 4E11 3-1.
2. Kimura, K., Chonai, S., Tomita, T., Kise, M., Nakamura, K. (Nippon Shinyaku Co., Ltd.). Pyroglutamide derivs. DE 3701494, FR 2597100, GB 2185483, JP 87252761, JP 87252762, JP 88146857, US 5102882.
3. Oka, M., Fukui, T., Itoh, Y., Ukai, Y., Kimura, K. NS-105, a novel nootropic agent, reverses GABAB receptor-mediated inhibition of cyclic AMP accumulation in the rat brain. J Neurochem 1995, 65(Suppl.): S164.
4. Oka, M., Fukui, T., Itoh, Y., Ukai, Y., Kimura, K. Antagonism of GABAB receptor-mediated inhibition of cAMP formation and PI turnover by a nootropic, NS-105, in the rat brain. Jpn J Pharmacol 1995, 67(Suppl. 1): Abst P3-47.
5. Nakagawa, Y., Tamura, M., Ogasawara, T., Ukai, Y., Kimura, K. Effects of a newly synthesized pyroglutaminamide derivative, LAM-105 on learning and memory in rats. Jpn J Pharmacol 1988, 46(Suppl.): Abst O-258.
6. Nakagawa, Y., Yamazaki, A., Tatsumi, S., Ukai, Y., Kimura, K. A pyroglutaminamide, LAM-105, improved the deficit in a spatial memory task induced by transient forebrain ischemia in rats. Jpn J Pharmacol 1990, 52(Suppl. 1): Abst P-491.
7. Ukai, Y., Nakagawa, Y., Ishima, T., Tamura, M., Yamazaki, A., Kimura, K. A pyroglutaminamide derivative, LAM-105, improves learning and memory in rats by enhancing the cholinergic neuronal activity. 17th Cong Coll Int Neuro-Psychopharmacol (Sept 10-14, Kyoto) 1990, Abst P-14-2-20.
8. B receptor up-regulation in the antidepressant activity of NS-105, a novel cognition enhancer. Jpn J Pharmacol 1994, 64(Suppl. 1): Abst P-44.
9. Kimura, K., Ukai, Y. (Nippon Shinyaku Co., Ltd.). Antidepressant. EP 711554, JP 95505738, WO 9503801.
10. Nippon Shinyaku Co., Ltd. Annual Report 1996.