Effect of metformin on glucose disposal and hyperinsulinaemia in a 14-year-old boy with acanthosis nigricans

Hormone Research in Paediatrics

Volumn 48, Issue 2, 1997, Pages 88-92

  Lee, Philip J ^a   Cranston, Iain ^b   Amiel, Stephanie A ^b   O’Rahilly, Stephen ^c   Green, Albert Aynsley ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Acanthosis nigricans; Biguanide; Hyperinsulinaemic euglycaemic clamp; Hyperinsulinism; Obesity

Indexed keywords

GLUCOSE; INSULIN; METFORMIN;

ACANTHOSIS NIGRICANS; ADOLESCENT; ARTICLE; BODY MASS; CASE REPORT; GASTROINTESTINAL DISEASE; GLUCONEOGENESIS; GLUCOSE METABOLISM; HUMAN; HYPERINSULINEMIA; INSULIN RESPONSE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PUBERTY; SKIN DEFECT;

EID: 0030814131     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000185493     Document Type: Article

References (20)

1. Stuart CA, Pate CJ, Peters EJ: Prevalence of acanthosis nigricans in an unsclccted population. Am J Med 1989;87:269-272.
2. Brown J, Winkelman RK: Acanthosis nigricans: A study of 90 cases. Medicine 1968:47: 33-40.
3. Richards GE, Cavallo A, Meyer WJ, Prince MJ, Peters EJ, Stuart CA, Smith ER: Obesity, acanthosis nigricans, insulin resistance, and hy-perandrogenemia: Pediatric perspective and natural history. J Pediatr 1985:1107:893-897.
4. Sobey WJ, Beer SF, Carrington CA, Clark PMS, Frank BH, Gray IP, Luzio SD, Owens DR, Schneider AE, Siddle K, Temple RC, Hales CN: Sensitive and specific two-site im-munoradiomctric assays for human insulin-proinsulin, 65-66 split and 32-33 split proinsulins. Biochem J 1989;260:535-541.
5. Powrie JK, Smith GD, Henncssy TR, Shojaee-Moradic F, Kelly JM, Sönksen PH, Jones RH: Incomplete suppression of hepatic glucose production in non-insulin dependent diabetes mellitus measured with [ö.ö-^Hi] glucose enriched glucose infusion during hyperinsulinaemie eu-glycaemic clamps. Eur J Clin Invest 1992:22: 244-253.
6. Steele R: Influences of glucose loading and injected insulin on hepatic glucose output. Ann NY Acad Sei 1959:82:420-430.
7. Amicl SA, Caprio S, Shcrwin RS, Plewe G, Haymond MW, Tantborlane WV: Insulin resistance of puberty: A defect restricted to peripheral glucose metabolism. J Clin Endocrinol Metab 1991;72:277-282.
8. Geffner ME, Golde DW: Selective insulin action on skin, ovary, and heart in insulin-resistant states. Diabetes Care 1988:11:500-505.
9. Mollier DE, Flier JS: Insulin resistance: Mechanisms. syndromes, and implications. N Engl J Med 1991;325:938-948.
10. Correnblum B, Bayliss BW: Medical therapy for the syndrome of familial virilization, insulin resistance, and acanthosis nigricans. Ferlil Steril 1990;53:421-425.
11. Kuzuya H, Matsuura N, Sakamoto M, Makino H, Sakamoto Y, Kadowaki T, Suzuki Y, Koayashi M, Akazawa Y, Nomura M, Yosho-mara Y, Kasuga M, Goji K, Nagataki S, Oyasu H, Imura H: Trial of insulin-like growth factor 1 therapy for patients with extreme insulin resistance syndromes. Diabetes 1993:42:696-705.
12. Ishihama H, Suzuki Y, Muramatsu K, Nagai M, Kokubo M, Shiraya H, Kawakita A, Nishi-mura Y, Imamura T. Kobayashi M: Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I. Arch Dis Child 1994:71:144-146.
13. Shcrcrtz EF: Improved acanthosis nigricans with lipodystrophic diabetes during dietary fish oil supplementation. Arch Dermatol 1988; 124:1094-1096.
14. Bailey CJ, Turner RC: Drug therapy: Metformin. N Engl J Med 1996:334:574-579.
15. Kozka IJ, Holman GD: Metformin blocks downregulation of cell surface GLUT4 caused by chronic insulin treatment of rat adipocytes. Diabetes 1993:42:1159-1165.
16. Stumvoll M, Nurjhan N, Perrello G, Dailey G, Gerich JE: Metabolic effects of metformin in non-insulin-dcpendent diabetes mellitus. N Engl J Med 1995;333:550-554.
17. Widen EIM, Eriksson J, Groop LC: Metformin normalizes nonoxidativc glucose metabolism in insulin-resistant normoglycemic first-degree relatives of patients with NIDDM. Diabetes 1992:41:354-358.
18. Gin H, Messerschmitt C, Brottier E, Aubertin I: Metformin improved insulin resistance in type 1. insulin dependent, diabetic patients. Metabolism 1985;34:923-925.
19. Pagano G, Tagliaferro V, Carta Q, Caselle MT, Bozzo C, Vitelli F, Trovati M, Cocuzza E: Metformin reduces insulin requirement in type I (insulin-dependent) diabetes. Diabetologia 1983;24:351-354.
20. Martha PM, Rogol AD, Veldhuis JD: Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys. J Clin Endocrinol Metab 1989:69: 563-570.