M33, a mammalian homologue of Drosophila Polycomb localises to euchromatin within interphase nuclei but is enriched within the centromeric heterochromatin of metaphase chromosomes

Cytogenetics and Cell Genetics

Volumn 78, Issue 1, 1997, Pages 50-55

  Wang, G ^a   Horsley, D ^a   Ma, A ^a   Otte, A P ^c   Hutchings, A ^b   Butcher, G W ^b   Singh, P B ^a  

^a Department of Development and Genetics ^*  (United States)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME PROTEIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CENTROMERE; DROSOPHILA; EUCHROMATIN; HETEROCHROMATIN; IMMUNOBLOTTING; INTERPHASE; METAPHASE; METAPHASE CHROMOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STAINING;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL NUCLEUS; CENTROMERE; CHROMATIN; DROSOPHILA; EUCHROMATIN; HETEROCHROMATIN; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERPHASE; MAMMALS; METAPHASE; MICE; REPRESSOR PROTEINS;

EID: 0030813669     PISSN: 03010171     EISSN: 1424859X     Source Type: Journal    
DOI: 10.1159/000134626     Document Type: Article

References (31)

1. Alkema MJ, Bronk M, Verhoeven H, Otte A, van’t Veer LJ, Berns A, van Lohuizen M: Identification of bmil-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev 11:226-240(1997).
2. Brunk BP, Martin EC, Adler PN: Drosophila genes Posterior Sex Combs and Suppressor two of:este encode proteins with homology to the murine bmi-I oncogene. Nature 353:351-353 (1991).
3. Bienz M, Muller J: Transcriptional silencing of hom-eotic genes in Drosophila. Bioessays 17:775-784 (1995).
4. Duncan I, Lewis EB: Genetic control of body segment differentiation in Drosophila, in: Developmental Order: Its Origin and Regulation, pp 533-554 (Alan R Liss, New York 1982).
5. Eamshaw WC, Bemat, RL: Chromosomal passengers: towards an integrated view of mitosis. Chromosoma 100:139-146(1990).
6. Franke A, DeCamiltis M, Zink D, Cheng N, Brock H W, Paro R: Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J 11:2941-2950(1992).
7. Franke A, Messmer S, Paro R: Mapping functional domains of the Polycomb protein of Drosophila melanogaster. Chrom Res 3:351 -360 (1995).
8. Gaunt SJ, Singh PB: Homeogenc expression patterns and chromosomal imprinting. Trends Genet 6:208-212(1990).
9. Galfre G, Milstein C, Wright B: Rat » rat hybrid myelomas and a monoclonal anti-Fc part of mouse IgG. Nature 277:131-133(1979).
10. Gecz J, Gaunt SJ, Passage E, Burton RD, Cudrey C, Pearce JJH, Fontes M: Assignment of a polycomblike chromobox gene (CBX2) to human chromosome 17q25. Genomics 26:130-133 (1995).
11. Gunster MJ, Satijn DPE, Hamer KM, den Blaauwen JL, de Bruijn, D, Alkema MJ, van Driel R, Otte AP: Identification and characterisation of interac-tionsbetween the vertebrate polycomb-group bmi 1 and human homologs of polyhomeotic. Mol Cell Biol 17 (in press 1997).
12. Hilwig I, Gropp A: Decondensation of constitutive heterochromatin in L cell chromosomes. Chromosoma 34:243-253(1971).
13. Horsley D, Hutchings A, Butcher GW, Singh PB: M32, a murine homologuc of Drosophila heterochromatin protein 1 (HPI), localises to euchromatin within inlerphase nuclei and is largely excluded from constitutive heterochromatin. Cylogenet Cell Genet 73:308-311(1996).
14. James TC, Elgin SCR: Identification of a nonhistone chromosomal protein associated with heterochro-matin in Drosophila melanogaster and its gene. Mol Cell Biol 6:3862-3872 (1986).
15. Jurgens G: A group of genes controlling spatial expression of the bithorax complex in Drosophila. Nature 316:153-155(1985).
16. Lewis EB: A gene complex controling segmentation in Drosophila. Nature 276:565-570 (1978).
17. Messmer S, Franke A, Paro R: Analysis of the functional roleof the Polycomb chromodomain in Drosophila melanogaster. Genes Dev 6:1241-1254 (1992).
18. Moroi Y, Peebles C, Fritzler MJ, Steigerwald J, Tan EM: Autoantibody to centromere (kinetochorc) in scleroderma sera. Proc natl Acad Sei, USA 77:1627-1631 (1980).
19. Muller J, Gaunt S, Lawrence P: Function of the Polycomb protein is conserved in mice and flies. Development 121:2847-2852(1995).
20. Orlando V, Paro R: Chromatin multiprotein complexes involved in the maintenance of transcription patterns. CurrOpin Gen Dev 5:174-179(1995).
21. Painter TS: A new method for the study of chromosome rearrangements and the plotting of chromosome maps. Science 78:585-586 (1933).
22. Paro R: Imprinting the determined state into the chromatin of Drosophila melanogaster. Trends Genet 6:416-421 (1990).
23. Paro R, Hogness DS: The Polycomb protein shares a homologous domain with a heterochromatin-asso-ciated protein of Drosophila. Proc natl Acad Sci. USA 88:263-267(1991).
24. Pearce JJ, Singh PB, Gaunt SJ: The mouse has a Poly-comb-like chromobox gene. Development 114:921-929(1992).
25. Rattner JB, Wang T, Mack G, Fritzler MJ, Martin L, Valencia D: MSA-36: A chromosome and mitotic spindle-associated protein. Chromosoma 101:625-633(1992).
26. Singh PB, Miller JR, Pearce J, Kothary R, Burton RD, Paro R, James TC, Gaunt SJ: A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucl Acids Res 19:789-794(1991).
27. Singh PB: Molecular mechanisms of cellular determination: their relation to chromatin structure and parental imprinting. J Cell Sci 107:2653-2668 (1994).
28. Singh PB, James, TC: Chromobox genes and the molecular mechanisms of cellular determination, in Ohlsson R, Hall K, Ritzen M (eds): Genomic imprinting: causes and consequences, pp 71-108 (Cambridge University Press, Cambridge 1995).
29. van Lohuizen M, Frasch M, Wicntjens E, Berns A: Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 353:353-355 (1991).
30. Wrcggett KA, Hill F, James PS, Hutchings A, Butcher GW, Singh PB: A mammalian homologue of Drosophila heterochromatin protein I (HPl)isacom-ponent of constitutive heterochromatin. Cytogenet Cell Genet 66:99-103(1994).
31. Zink B, Paro R: In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster. Nature 337:468-471 (1989).