Breaks in double-strand DNA by Cu(II) complexes of etoposide (VP-16) and its derivatives, as evaluated by S1 nuclease treatment

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 9, 1997, Pages 1002-1005

  Tawa, Riichi ^a   Takami, Masashi ^a   Imakura, Yasuhiro ^b   Lee, Kuo Hsiung ^c   Sakurai, Hiromu ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b NARUTO UNIVERSITY OF EDUCATION   (Japan)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

5 methylcytosine; Copper(II) ion; DNA strand breaks; Hydroxyl radical ( OH); S1 nuclease; VP 16 (etoposide)

Indexed keywords

COPPER COMPLEX; DOUBLE STRANDED DNA; ETOPOSIDE; ETOPOSIDE DERIVATIVE; NUCLEASE S1; SYRINGIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; DNA CONFORMATION; DNA METHYLATION; DNA REPLICATION; DNA STRAND BREAKAGE;

EID: 0030813466     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.1002     Document Type: Article

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