메뉴 건너뛰기




Volumn 14, Issue 2, 1997, Pages 83-89

Targeting signal transduction for disease therapy

Author keywords

Disease therapy; Epidermal growth factor; Platelet derived growth factor; Targetting signal transduction

Indexed keywords

ALPHA (3,4 DIMETHOXYBENZYLIDENE) 2 PYRIDYLACETONITRILE; ALPHA (3,5 DICHLOROBENZYLIDENE) 3 PYRIDYLACETONITRILE; CD19 ANTIGEN; CELL NUCLEUS RECEPTOR; CYCLIN DEPENDENT KINASE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; FULVESTRANT; GENISTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; ONCOPROTEIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAS PROTEIN; TAMOXIFEN; TRANSCRIPTION FACTOR; TYRPHOSTIN;

EID: 0030813014     PISSN: 07360118     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02990952     Document Type: Article
Times cited : (21)

References (63)
  • 1
    • 0028000069 scopus 로고
    • Signal transduction therapy
    • Levitzki, A. (1994) Signal transduction therapy. Eur. J. Biochem. 226, 1-3.
    • (1994) Eur. J. Biochem. , vol.226 , pp. 1-3
    • Levitzki, A.1
  • 2
    • 0028069064 scopus 로고
    • Signaling pathways as targets for anticancer drugs
    • Powis, G. (1994) Signaling pathways as targets for anticancer drugs. Pharmacol. Ther. 62, 57-95.
    • (1994) Pharmacol. Ther. , vol.62 , pp. 57-95
    • Powis, G.1
  • 3
    • 0024240990 scopus 로고
    • Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors
    • Yaish, P., Gazit, A., Gilon, C. and Levitzki, A. (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242, 933-35.
    • (1988) Science , vol.242 , pp. 933-935
    • Yaish, P.1    Gazit, A.2    Gilon, C.3    Levitzki, A.4
  • 4
    • 0024434810 scopus 로고
    • Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors
    • Gazit, A., Yaish, P., Gilon, C. and Levitzki, A. (1989) Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J. Med. Chem. 32, 2344-52.
    • (1989) J. Med. Chem. , vol.32 , pp. 2344-2352
    • Gazit, A.1    Yaish, P.2    Gilon, C.3    Levitzki, A.4
  • 5
    • 0025988512 scopus 로고
    • The antiproliferative effects of tyrosine kinase inhibitor tyrphostin on a human squamous cell carcinoma in vitro and in nude mice
    • Yoneda, T., Lyall, R., Alsine, M.M., Pearsons, P.E., Spada, A.P., Levitzki, A., Zilberstein, A. and Mundy, G.R. (1991) The antiproliferative effects of tyrosine kinase inhibitor tyrphostin on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 51, 4430-5.
    • (1991) Cancer Res. , vol.51 , pp. 4430-4435
    • Yoneda, T.1    Lyall, R.2    Alsine, M.M.3    Pearsons, P.E.4    Spada, A.P.5    Levitzki, A.6    Zilberstein, A.7    Mundy, G.R.8
  • 8
    • 0030044628 scopus 로고    scopus 로고
    • Enhancement of chemosensitivity by tyrphostin AG 825 in high p185neu expressing non-small cell lung cancer cells
    • Tsai, C.M., Levitzki, A., Wu, L.H., Chang, K.T., Chen, J.U., Cheng, C.C., Gazit, A. and Peng, R.P. (1996) Enhancement of chemosensitivity by tyrphostin AG 825 in high p185neu expressing non-small cell lung cancer cells. Cancer Res. 56, 1068-74.
    • (1996) Cancer Res. , vol.56 , pp. 1068-1074
    • Tsai, C.M.1    Levitzki, A.2    Wu, L.H.3    Chang, K.T.4    Chen, J.U.5    Cheng, C.C.6    Gazit, A.7    Peng, R.P.8
  • 10
    • 0026521394 scopus 로고
    • Amplified and rearranged epidermal growth factor receptors genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
    • Ekstrand, A.J., Sugawa, N., James, C.D. and Collins, V.P. (1992) Amplified and rearranged epidermal growth factor receptors genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc. Natl. Acad. Sci. USA 89, 4309-13.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4309-4313
    • Ekstrand, A.J.1    Sugawa, N.2    James, C.D.3    Collins, V.P.4
  • 11
    • 0030063104 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) promotes chemomigration of a human prostate tumor cell line, and EGF immunoreactive proteins are present at sites of metastasis in the stroma of lymph nodes and medullary bone
    • Rajan, R., Vanderslice, R., Kapur, S., Lynch, J., Thompson, R. and Djakiew, D. (1996) Epidermal growth factor (EGF) promotes chemomigration of a human prostate tumor cell line, and EGF immunoreactive proteins are present at sites of metastasis in the stroma of lymph nodes and medullary bone. Prostate 28, 1-9.
    • (1996) Prostate , vol.28 , pp. 1-9
    • Rajan, R.1    Vanderslice, R.2    Kapur, S.3    Lynch, J.4    Thompson, R.5    Djakiew, D.6
  • 12
    • 0027690442 scopus 로고
    • Expression of transforming growth factor-alpha, epidermal growth factor and the epidermal growth factor receptor in adenocarcinoma of the prostate and benign prostatic hyperplasia
    • Myers, R.B., Kudlow, J.E. and Grizzle, W.E. (1993) Expression of transforming growth factor-alpha, epidermal growth factor and the epidermal growth factor receptor in adenocarcinoma of the prostate and benign prostatic hyperplasia. Mod. Pathol. 6, 733-7.
    • (1993) Mod. Pathol. , vol.6 , pp. 733-737
    • Myers, R.B.1    Kudlow, J.E.2    Grizzle, W.E.3
  • 13
    • 0029837306 scopus 로고    scopus 로고
    • Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors
    • Han, Y., Caday, C.G., Nanda, A., Cavenee, W.K. and Huang, H.J. (1996) Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res. 56, 3859-61.
    • (1996) Cancer Res. , vol.56 , pp. 3859-3861
    • Han, Y.1    Caday, C.G.2    Nanda, A.3    Cavenee, W.K.4    Huang, H.J.5
  • 15
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon, D.J., Clark, G.M., Wong, S.G., Levin, W.I., Ullrich, A. and McGuire, W.L. (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177-82.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.I.4    Ullrich, A.5    McGuire, W.L.6
  • 16
    • 0025933703 scopus 로고
    • Platelet-derived growth factor and autocrine mechanisms of oncogenic processes
    • Heldin, C.H. and Westermark, B. (1991) Platelet-derived growth factor and autocrine mechanisms of oncogenic processes. CRC Crit. Rev. Oncog. 2, 109-24.
    • (1991) CRC Crit. Rev. Oncog. , vol.2 , pp. 109-124
    • Heldin, C.H.1    Westermark, B.2
  • 17
    • 0027131289 scopus 로고
    • Tyrphostin 3. Structure activity relation-ship studies of 5-S-Aryl α-substituted Benzylidenemalononitrile Tyrphostins
    • Gazit, A., Osherov, N., Posner, I., Bar-Sinai, A., Gilon, C. and Levitzki, A. (1993) Tyrphostin 3. Structure activity relation-ship studies of 5-S-Aryl α-substituted Benzylidenemalononitrile Tyrphostins. J. Med. Chem. 36, 3556-64.
    • (1993) J. Med. Chem. , vol.36 , pp. 3556-3564
    • Gazit, A.1    Osherov, N.2    Posner, I.3    Bar-Sinai, A.4    Gilon, C.5    Levitzki, A.6
  • 18
    • 0029899585 scopus 로고    scopus 로고
    • Tyrphostins 5.-Potent Inhibitors of PDGF receptor tyrosine kinase. SAR in Quinixalines, Quinolines and Indole tyrphostins
    • Gazit, A., App, H., McMahon, G., Chen, J., Levitzki, A. and Bohmer, F.D. (1996) Tyrphostins 5.-Potent Inhibitors of PDGF receptor tyrosine kinase. SAR in Quinixalines, Quinolines and Indole tyrphostins. J. Med. Chem., 39, 2170-7.
    • (1996) J. Med. Chem. , vol.39 , pp. 2170-2177
    • Gazit, A.1    App, H.2    McMahon, G.3    Chen, J.4    Levitzki, A.5    Bohmer, F.D.6
  • 20
    • 0029994470 scopus 로고    scopus 로고
    • SRC as a target for anti-cancer drugs
    • Levitzki, A. (1996) SRC as a target for anti-cancer drugs. Anti Cancer Drug Design 11, 175-82.
    • (1996) Anti Cancer Drug Design , vol.11 , pp. 175-182
    • Levitzki, A.1
  • 22
    • 0028846008 scopus 로고
    • VEGF mediated tumor angiogenesis: A new target for cancer therapy
    • Martiny-Baron, G. and Norme, D. (1995) VEGF mediated tumor angiogenesis: a new target for cancer therapy. Curr. Op. Biotech. 6, 675-80.
    • (1995) Curr. Op. Biotech. , vol.6 , pp. 675-680
    • Martiny-Baron, G.1    Norme, D.2
  • 30
    • 0028171075 scopus 로고
    • Epidermal growth factor dependent activation of Src family kinases
    • Osherov, N. and Levitzki, A. (1994) Epidermal growth factor dependent activation of Src family kinases. Eur. J. Biochem. 225, 1047-53.
    • (1994) Eur. J. Biochem. , vol.225 , pp. 1047-1053
    • Osherov, N.1    Levitzki, A.2
  • 32
    • 0028180234 scopus 로고
    • 4,5-Dianilinophthalimide: A protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo and tumor activity
    • Buchdunger, E., Trinks, U., Mett, H., Regenass, U., Muller, M., Meyer, T., McGlynn, E., Pinna, L.A., Traxler, P. and Lydon, N.G. (1994) 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo and tumor activity. Proc. Natl. Acad. Sci. USA 91, 2334-8.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2334-2338
    • Buchdunger, E.1    Trinks, U.2    Mett, H.3    Regenass, U.4    Muller, M.5    Meyer, T.6    McGlynn, E.7    Pinna, L.A.8    Traxler, P.9    Lydon, N.G.10
  • 33
    • 0028968949 scopus 로고
    • Tyrosine kinases inhibition: An approach to drug development
    • Levitzki, A. and Gazit, A. (1995) Tyrosine kinases inhibition: An approach to drug development. Science 267, 1782-8.
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 34
    • 0027198702 scopus 로고
    • Selective inhibition of the EGF and HER2/Neu receptors by tyrphostins
    • Osherov, N., Gazit, A., Gilon, C. and Levitzki, A. (1993) Selective inhibition of the EGF and HER2/Neu receptors by tyrphostins. J. Biol. Chem. 268, 11134-42.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11134-11142
    • Osherov, N.1    Gazit, A.2    Gilon, C.3    Levitzki, A.4
  • 36
    • 0028968622 scopus 로고
    • Selective inhibition of the platelet derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimideine class
    • Buchdunger, E., Zimmermann, J., Mett, H., Meyer, T., Muller, M., Regenass, U. and Lydon, N.B. (1995) Selective inhibition of the platelet derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimideine class. Proc. Natl. Acad. Sci. USA 28, 2558-62.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.28 , pp. 2558-2562
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5    Regenass, U.6    Lydon, N.B.7
  • 37
    • 0027255141 scopus 로고
    • Tyrphostins induce differentiation of mouse erythroleukemia cells
    • Anafi, M., Ben-Neriah, Y. and Levitzki, A. (1993) Tyrphostins induce differentiation of mouse erythroleukemia cells. FEBS Lett. 330, 260-4.
    • (1993) FEBS Lett. , vol.330 , pp. 260-264
    • Anafi, M.1    Ben-Neriah, Y.2    Levitzki, A.3
  • 39
    • 0028670569 scopus 로고
    • In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence
    • Choo, Y., Sanchez-Garcia, I. and Klug, A. (1994) In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence. Nature 372, 642-645.
    • (1994) Nature , vol.372 , pp. 642-645
    • Choo, Y.1    Sanchez-Garcia, I.2    Klug, A.3
  • 40
    • 0027384743 scopus 로고
    • Ribozyme-mediated cleavage of the BCR-ABL oncogene transcript: In vitro cleavage of RNA and in vivo loss of P210 protein kinase activity
    • Shore, S.K., Nabissa, P.M. and Reddy, E.P. (1993) Ribozyme-mediated cleavage of the BCR-ABL oncogene transcript: in vitro cleavage of RNA and in vivo loss of P210 protein kinase activity. Oncogene 8, 3183-8.
    • (1993) Oncogene , vol.8 , pp. 3183-3188
    • Shore, S.K.1    Nabissa, P.M.2    Reddy, E.P.3
  • 41
    • 0027767671 scopus 로고
    • Tamoxifen therapy in breast cancer worldwide
    • Love, R.R. and Korolchouk, V. (1993) Tamoxifen therapy in breast cancer worldwide. Bull. Wld. Hlth. Organ. 71, 795-803.
    • (1993) Bull. Wld. Hlth. Organ. , vol.71 , pp. 795-803
    • Love, R.R.1    Korolchouk, V.2
  • 42
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling, A.E., Dukes, M. and Bowler, J. (1991) A potent specific pure antiestrogen with clinical potential. Cancer Res. 51, 3867-73.
    • (1991) Cancer Res. , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 43
    • 0028028068 scopus 로고
    • Receptor blockade with monoclonal antibodies as anti-cancer therapy
    • Besalga, J. and Mendelson, J. (1994) Receptor blockade with monoclonal antibodies as anti-cancer therapy. Pharmacol. Ther. 64, 127-54.
    • (1994) Pharmacol. Ther. , vol.64 , pp. 127-154
    • Besalga, J.1    Mendelson, J.2
  • 45
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990's
    • Ross, R.C. (1993) The pathogenesis of atherosclerosis: A perspective for the 1990's. Nature 302, 801-9.
    • (1993) Nature , vol.302 , pp. 801-809
    • Ross, R.C.1
  • 46
    • 0026666967 scopus 로고
    • Inhibition of platelet derived growth factor (PDGF) induced mitogenic activity by PDGF receptor tyrosine kinase tyrphostin inhibitors
    • Bryckaert, M.C., Eldor, A., Gazit, A., Osherov, N., Gilon, C., Fontenay, M., Levitzki, A. and Tobelem, G. (1992) Inhibition of platelet derived growth factor (PDGF) induced mitogenic activity by PDGF receptor tyrosine kinase tyrphostin inhibitors. Exp. Cell Res. 199, 255-61.
    • (1992) Exp. Cell Res. , vol.199 , pp. 255-261
    • Bryckaert, M.C.1    Eldor, A.2    Gazit, A.3    Osherov, N.4    Gilon, C.5    Fontenay, M.6    Levitzki, A.7    Tobelem, G.8
  • 50
    • 0024535228 scopus 로고
    • The human Papillomavirus-16 E7 is able to bind the retinoblastoma gene product
    • Dyson, N., Howley, P.M., Munger, K. and Harlow, E. (1989) The human Papillomavirus-16 E7 is able to bind the retinoblastoma gene product. Science 243, 934-7.
    • (1989) Science , vol.243 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Munger, K.3    Harlow, E.4
  • 51
    • 26844442354 scopus 로고
    • Association of human papilloma virus type 16 and 18 with p53
    • Werness, B.A., Levine, A.J. and Howley, P.M. (1990) Association of human papilloma virus type 16 and 18 with p53. Science 248, 934-7.
    • (1990) Science , vol.248 , pp. 934-937
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 52
    • 0028138582 scopus 로고
    • Targeted expression of the E6 and E7 oncogenes of human papilloma virus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors
    • Auewarakul, P., Gissmaa, L. and Cid-Arregui, A. (1994) Targeted expression of the E6 and E7 oncogenes of human papilloma virus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors. Mol. Cell. Biol. 14, 8250-8.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8250-8258
    • Auewarakul, P.1    Gissmaa, L.2    Cid-Arregui, A.3
  • 53
    • 26844479982 scopus 로고    scopus 로고
    • Blockers of EGF receptor and the cell cycle induce growth arrest, differentiation and apoptosis in HPV 16 immortalized human keratinocytes
    • in press
    • Ben-Bassat, H. (1997) Blockers of EGF receptor and the cell cycle induce growth arrest, differentiation and apoptosis in HPV 16 immortalized human keratinocytes. Cancer Res. (in press).
    • (1997) Cancer Res.
    • Ben-Bassat, H.1
  • 54
    • 0024376173 scopus 로고
    • Ras oncogenes and human cancer
    • Boss, J.L. (1989) Ras oncogenes and human cancer. Cancer Res. 49, 4682-9.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Boss, J.L.1
  • 55
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl: Protein transferase blocks the anchorage-dependent and independent growth of human tumor cell lines
    • Stepp-Lorenzino, L., Zhenping, M., Rands, E., Kohl, N.E., Gibbs, J.B., Oliff, A. and Rosen N. (1995) A peptidomimetic inhibitor of farnesyl: protein transferase blocks the anchorage-dependent and independent growth of human tumor cell lines. Cancer Res. 55, 5302-9.
    • (1995) Cancer Res. , vol.55 , pp. 5302-5309
    • Stepp-Lorenzino, L.1    Zhenping, M.2    Rands, E.3    Kohl, N.E.4    Gibbs, J.B.5    Oliff, A.6    Rosen, N.7
  • 56
    • 0027175224 scopus 로고
    • Residues crucial for Ras interaction with GDP-GTP exchangers
    • Segal, M., Willumsen, B.M. and Levitzki, A. (1993) Residues crucial for Ras interaction with GDP-GTP exchangers. Proc. Natl. Acad. Sci. USA 90, 5564-8.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5564-5568
    • Segal, M.1    Willumsen, B.M.2    Levitzki, A.3
  • 57
    • 0028808638 scopus 로고
    • The Roc Rho pathways as a source for drug targets for Ras-mediated malignancies
    • Symons, M. (1995) The Roc Rho pathways as a source for drug targets for Ras-mediated malignancies. Curr. Op. Biotech. 6, 668-74.
    • (1995) Curr. Op. Biotech. , vol.6 , pp. 668-674
    • Symons, M.1
  • 58
    • 0028991396 scopus 로고
    • Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia
    • Cordon-Cardo, C. (1995) Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am. J. Pathol. 147, 545-60.
    • (1995) Am. J. Pathol. , vol.147 , pp. 545-560
    • Cordon-Cardo, C.1
  • 59
    • 0030785696 scopus 로고    scopus 로고
    • Tyrphostin AG 494 blocks Cdk2 activation
    • Osterov, N. and Levitzki, A. (1997) Tyrphostin AG 494 blocks Cdk2 activation. FEBS lett. 410, 187-190.
    • (1997) FEBS Lett. , vol.410 , pp. 187-190
    • Osterov, N.1    Levitzki, A.2
  • 62
    • 0026653293 scopus 로고
    • Ribozymes designed to inhibit transformation of MH 3T3 cells by the activated c-Ha-ras gene
    • Koizumi, M., Kamiya, H. and Ohtsuka, E. (1992) Ribozymes designed to inhibit transformation of MH 3T3 cells by the activated c-Ha-ras gene. Gene 17, 179-84.
    • (1992) Gene , vol.17 , pp. 179-184
    • Koizumi, M.1    Kamiya, H.2    Ohtsuka, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.