메뉴 건너뛰기




Volumn 197, Issue 2, 1997, Pages 63-79

The proteoglycan metabolism, morphology and viability of articular cartilage treated with a synthetic matrix metalloproteinase inhibitor

Author keywords

Cartilage; Interleukin 1; Matrix metalloproteinase; Proteoglycan; Synthetic inhibitor

Indexed keywords

INTERLEUKIN 1; MATRIX METALLOPROTEINASE INHIBITOR; N [2 [2 (HYDROXYAMINO) 2 OXOETHYL] 4 METHYL 1 OXOPENTYL]LEUCYLPHENYLALANINAMIDE; PROTEOGLYCAN; UNCLASSIFIED DRUG;

EID: 0030812958     PISSN: 03009130     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004330050056     Document Type: Article
Times cited : (2)

References (47)
  • 1
    • 0026737382 scopus 로고
    • A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro
    • Andrews HJ, Plumpton TA, Harper GP, Cawston TE (1992) A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro. Agents Actions 37:147-154
    • (1992) Agents Actions , vol.37 , pp. 147-154
    • Andrews, H.J.1    Plumpton, T.A.2    Harper, G.P.3    Cawston, T.E.4
  • 2
    • 0022998478 scopus 로고
    • Purification and characterization of an acid metalloproteinase from human articular cartilage
    • Azzo W, Woessner JF (1986) Purification and characterization of an acid metalloproteinase from human articular cartilage. J Biol Chem 261:5434-5441
    • (1986) J Biol Chem , vol.261 , pp. 5434-5441
    • Azzo, W.1    Woessner, J.F.2
  • 3
    • 0023914781 scopus 로고
    • Inhibitors of mammalian tissue collagenase and metalloproteinase suppress ovulation in the perfused rat ovary
    • Brännström M, Woessner JF Jr, Koos RD, Sear CHJ, LeMaire WJ (1988) Inhibitors of mammalian tissue collagenase and metalloproteinase suppress ovulation in the perfused rat ovary. Endocrinology 122:1715-1721
    • (1988) Endocrinology , vol.122 , pp. 1715-1721
    • Brännström, M.1    Woessner Jr., J.F.2    Koos, R.D.3    Sear, C.H.J.4    Lemaire, W.J.5
  • 5
    • 0025043647 scopus 로고
    • Fibronectin and proteoglycan synthesis in long term cultures of cartilage explants in Ham's F-12 supplemented with insulin and calcium: Effects of the addition of TGF-β
    • Burton-WursterN, Lust G (1990) Fibronectin and proteoglycan synthesis in long term cultures of cartilage explants in Ham's F-12 supplemented with insulin and calcium: effects of the addition of TGF-β. Arch Biochem Biophys 283:27-33
    • (1990) Arch Biochem Biophys , vol.283 , pp. 27-33
    • Burton-Wurster, N.1    Lust, G.2
  • 6
    • 0027438713 scopus 로고
    • Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation
    • Buttle DJ, Handley CJ, Ilic MZ, Saklatvala J, Murata M, Barrett AJ (1993) Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthritis Rheum 36:1709-1717
    • (1993) Arthritis Rheum , vol.36 , pp. 1709-1717
    • Buttle, D.J.1    Handley, C.J.2    Ilic, M.Z.3    Saklatvala, J.4    Murata, M.5    Barrett, A.J.6
  • 7
    • 0026010992 scopus 로고
    • Recombinant human interleukin 1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes
    • Campbell IK, Last K, Novak U (1991) Recombinant human interleukin 1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes. Biochem Biophys Res Commun 174:251-254
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 251-254
    • Campbell, I.K.1    Last, K.2    Novak, U.3
  • 10
    • 0003086134 scopus 로고
    • Proteoglycans
    • Chaplin MF, Kennedy JF (eds) IRL Press, Oxford
    • Carney SL (1986) Proteoglycans. In: Chaplin MF, Kennedy JF (eds) Carbohydrate analysis. A practical approach, IRL Press, Oxford, pp 97-142
    • (1986) Carbohydrate Analysis. A Practical Approach , pp. 97-142
    • Carney, S.L.1
  • 11
    • 0028651849 scopus 로고
    • Role of TIMP and MMP inhibitors in preventing connective tissue breakdown
    • Cawston T, Plempton T, Curry V, Ellis A, Powell L (1994) Role of TIMP and MMP inhibitors in preventing connective tissue breakdown. Ann NY Acad Sci 732:75-83
    • (1994) Ann NY Acad Sci , vol.732 , pp. 75-83
    • Cawston, T.1    Plempton, T.2    Curry, V.3    Ellis, A.4    Powell, L.5
  • 12
    • 0030033710 scopus 로고    scopus 로고
    • Chondrocyte matrix metalloproteinase-8: Upregulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints
    • Chubinskaya S, Huch K, Mikecz K, Cs-Szabo G, Hasty KA, Kuettner KE, Cole AA (1996) Chondrocyte matrix metalloproteinase-8: upregulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints. Lab Invest 74:232-235
    • (1996) Lab Invest , vol.74 , pp. 232-235
    • Chubinskaya, S.1    Huch, K.2    Mikecz, K.3    Cs-Szabo, G.4    Hasty, K.A.5    Kuettner, K.E.6    Cole, A.A.7
  • 14
    • 0029593259 scopus 로고
    • MMP-8 mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage
    • Cole AA, Kuettner KE (1995) MMP-8 mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage. Acta Orthop Scand 266:98-102
    • (1995) Acta Orthop Scand , vol.266 , pp. 98-102
    • Cole, A.A.1    Kuettner, K.E.2
  • 15
    • 0028641282 scopus 로고
    • Preclinical antiarthritic activity of matrix metalloproteinase inhibitors
    • DiMartino MJ, High W, Galloway WA, Crimmin MJ (1994) Preclinical antiarthritic activity of matrix metalloproteinase inhibitors. Ann NY Acad Sei 732:411-13
    • (1994) Ann NY Acad Sei , vol.732 , pp. 411-413
    • Dimartino, M.J.1    High, W.2    Galloway, W.A.3    Crimmin, M.J.4
  • 16
    • 0023007371 scopus 로고
    • Proteoglycan- And collagen-degrading enzymes from human interleukin-l stimulated chondrocytes from several species: Proteoglycanase and collagenase inhibitors as potentially new disease-modifiying antiarthritic agents
    • DiPasquale G, Caccese R, Pasternak R, Conaty J, Hubbs S, Perry K (1986) proteoglycan- and collagen-degrading enzymes from human interleukin-l stimulated chondrocytes from several species: proteoglycanase and collagenase inhibitors as potentially new disease-modifiying antiarthritic agents. Proc Soc Exp Biol Med 183:262-267
    • (1986) Proc Soc Exp Biol Med , vol.183 , pp. 262-267
    • Dipasquale, G.1    Caccese, R.2    Pasternak, R.3    Conaty, J.4    Hubbs, S.5    Perry, K.6
  • 17
    • 0023187537 scopus 로고
    • In vivo studies of articular tissue damage mediated by catabolin/interleukin 1
    • Dingle JT, Page Thomas DP, King B, Bard DR (1987) In vivo studies of articular tissue damage mediated by catabolin/interleukin 1. Ann Rheum Dis 46:527-533
    • (1987) Ann Rheum Dis , vol.46 , pp. 527-533
    • Dingle, J.T.1    Page Thomas, D.P.2    King, B.3    Bard, D.R.4
  • 18
    • 0028334568 scopus 로고
    • The prevention of collagen breakdown in bovine nasal cartilage by TIMP, TIMP-2 and a low molecular weight synthetic inhibitor
    • Ellis AJ, Curry VA, Powell EK, Cawston, TE (1994) The prevention of collagen breakdown in bovine nasal cartilage by TIMP, TIMP-2 and a low molecular weight synthetic inhibitor. Biochem Biophys Res Commun 201:94-101
    • (1994) Biochem Biophys Res Commun , vol.201 , pp. 94-101
    • Ellis, A.J.1    Curry, V.A.2    Powell, E.K.3    Cawston, T.E.4
  • 19
    • 0022552896 scopus 로고
    • Improved quantitation and discrimination of sulphatedglycosaminoglycansby use of dimethylmethylene blue
    • Farndale RW, Buttle DJ, Barrett AJ (1986) Improved quantitation and discrimination of sulphatedglycosaminoglycansby use of dimethylmethylene blue. Biochim Biophys Acta 883:173-177
    • (1986) Biochim Biophys Acta , vol.883 , pp. 173-177
    • Farndale, R.W.1    Buttle, D.J.2    Barrett, A.J.3
  • 20
    • 0025485305 scopus 로고
    • Visualization of living terminal hypertrophie chondrocytes of growth plate cartilage in situ by differential interference contrast microscopy and time-lapse cinematography
    • Farnum CE, Turgai J, Wilsman NJ (1990) Visualization of living terminal hypertrophie chondrocytes of growth plate cartilage in situ by differential interference contrast microscopy and time-lapse cinematography. J Orthop Res 8:750-763
    • (1990) J Orthop Res , vol.8 , pp. 750-763
    • Farnum, C.E.1    Turgai, J.2    Wilsman, N.J.3
  • 22
    • 0026701977 scopus 로고
    • Interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B
    • Fosang AJ, Neame PJ, Last K, Hardingham TE, Murphy G, Hamilton JA (1992) Interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B. J Biol Chem 267:19470-19474
    • (1992) J Biol Chem , vol.267 , pp. 19470-19474
    • Fosang, A.J.1    Neame, P.J.2    Last, K.3    Hardingham, T.E.4    Murphy, G.5    Hamilton, J.A.6
  • 23
    • 0027030121 scopus 로고
    • Inhibition of human skin fibroblast collagenase by phosphorous-containing peptides
    • Birkedal-Hansen Z, Werb Z, Welgus HG, Van Wart HE (eds) Gustav Fischer, Stuttgart
    • Galardy RE, Grobelny D, Kortylewiez ZP, Poncz L (1992) Inhibition of human skin fibroblast collagenase by phosphorous-containing peptides. In: Birkedal-Hansen Z, Werb Z, Welgus HG, Van Wart HE (eds) Matrix metalloproteinases and inhibitors (Matrix spec, suppl. no. 1 ). Gustav Fischer, Stuttgart, pp 259-262
    • (1992) Matrix Metalloproteinases and Inhibitors , Issue.1 MATRIX SPEC. SUPPL. , pp. 259-262
    • Galardy, R.E.1    Grobelny, D.2    Kortylewiez, Z.P.3    Poncz, L.4
  • 24
    • 0022437174 scopus 로고
    • Inhibition of mammalian collagenases by thiol-containing peptides
    • Gray RD, Miller RB, Spatola AF (1986) Inhibition of mammalian collagenases by thiol-containing peptides. J Cell Biochem 32:71-77
    • (1986) J Cell Biochem , vol.32 , pp. 71-77
    • Gray, R.D.1    Miller, R.B.2    Spatola, A.F.3
  • 25
    • 0021026820 scopus 로고
    • Dipeptide-hydroxamates are good inhibitors of the angiotensin I-converting enzyme
    • Harris RB, Strong PD, Wilson IB (1983) Dipeptide-hydroxamates are good inhibitors of the angiotensin I-converting enzyme. Biochem Biophys Res Commun I 16:394-399
    • (1983) Biochem Biophys Res Commun I , vol.16 , pp. 394-399
    • Harris, R.B.1    Strong, P.D.2    Wilson, I.B.3
  • 26
    • 0025317277 scopus 로고
    • The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis
    • Hasty KA, Reife RA, Kang AH, Stuart JM (1990) The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis. Arthritis Rheum 33:388-397
    • (1990) Arthritis Rheum , vol.33 , pp. 388-397
    • Hasty, K.A.1    Reife, R.A.2    Kang, A.H.3    Stuart, J.M.4
  • 27
    • 0023085534 scopus 로고
    • Isolation and characterization of proteoglycans
    • Heinegard D, Sommarin Y (1987) Isolation and characterization of proteoglycans. Methods Enzymol 144:319-372
    • (1987) Methods Enzymol , vol.144 , pp. 319-372
    • Heinegard, D.1    Sommarin, Y.2
  • 29
    • 0023619941 scopus 로고
    • Collagenase inhibitors: Their design and potential therapeutic use
    • Johnson WH, Roberts NA, Barkakoti N ( 1987) Collagenase inhibitors: their design and potential therapeutic use. J Enzyme Inhib 2:1-22
    • (1987) J Enzyme Inhib , vol.2 , pp. 1-22
    • Johnson, W.H.1    Roberts, N.A.2    Barkakoti, N.3
  • 30
    • 0015046195 scopus 로고
    • Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips
    • Mankin HJ, Dorfman H, Lippiello L and Zarins A (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. J Bone Joint Surg Am 53:523-537
    • (1971) J Bone Joint Surg Am , vol.53 , pp. 523-537
    • Mankin, H.J.1    Dorfman, H.2    Lippiello, L.3    Zarins, A.4
  • 31
    • 0025230509 scopus 로고
    • Metalloproteinases and their inhibitors in matrix remodeling
    • Matrisian LM (1990) Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6:121-125
    • (1990) Trends Genet , vol.6 , pp. 121-125
    • Matrisian, L.M.1
  • 32
    • 0024741792 scopus 로고
    • Factors involved in the regulation of proteoglycan metabolism in articular cartilage
    • Morales TI, Hascall VC (1989) Factors involved in the regulation of proteoglycan metabolism in articular cartilage. Arthritis Rheum 32:1197-1201
    • (1989) Arthritis Rheum , vol.32 , pp. 1197-1201
    • Morales, T.I.1    Hascall, V.C.2
  • 33
    • 0027417543 scopus 로고
    • Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage
    • Mort JS, Dodge GR, Roughley PJ, Liu J, Finch SJ, DiPasquale G, Poole AR (1993) Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage. Matrix 13:95-102
    • (1993) Matrix , vol.13 , pp. 95-102
    • Mort, J.S.1    Dodge, G.R.2    Roughley, P.J.3    Liu, J.4    Finch, S.J.5    Dipasquale, G.6    Poole, A.R.7
  • 35
    • 0019157310 scopus 로고
    • An improved assay for proteases and polysaccharidases employing a cartilage proteoglycan substrate entrapped in polyacrylamide particles
    • Nagase H, Woessner JF (1980) An improved assay for proteases and polysaccharidases employing a cartilage proteoglycan substrate entrapped in polyacrylamide particles. Anal Biochem 107:385-392
    • (1980) Anal Biochem , vol.107 , pp. 385-392
    • Nagase, H.1    Woessner, J.F.2
  • 38
    • 0030152317 scopus 로고    scopus 로고
    • Chondrocyte survival in cryopreserved osteochondral articular cartilage
    • Ohlendorf C, Tomford WW, Mankin HJ (1996) Chondrocyte survival in cryopreserved osteochondral articular cartilage. J Orthop Res 14:413-416
    • (1996) J Orthop Res , vol.14 , pp. 413-416
    • Ohlendorf, C.1    Tomford, W.W.2    Mankin, H.J.3
  • 39
    • 0000402498 scopus 로고
    • Etiopathogenesis of osteoarthritis
    • McCarthy, Koopman WJ (eds) Lea & Febiger, Philadelphia
    • Pelletier JP, Howell DS (1993) Etiopathogenesis of osteoarthritis. In: McCarthy, Koopman WJ (eds) Arthritis and allied conditions, 12th edn. Lea & Febiger, Philadelphia, pp 1723-1734
    • (1993) Arthritis and Allied Conditions, 12th Edn. , pp. 1723-1734
    • Pelletier, J.P.1    Howell, D.S.2
  • 40
    • 0000609002 scopus 로고
    • Interleukin 1 induces leucocyte infiltration and cartilage proteoglycan degradation in the synovial joint
    • Pettipher ER, Higgs GA, Henderson B (1986) Interleukin 1 induces leucocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Proc Natl Acad Sei USA 85:8749-8853
    • (1986) Proc Natl Acad Sei USA , vol.85 , pp. 8749-8853
    • Pettipher, E.R.1    Higgs, G.A.2    Henderson, B.3
  • 41
    • 0026682509 scopus 로고
    • The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain
    • Sandy JD, Flannery CR, Neame PJ, Lohmander LS (1992) The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. J Clin Invest 89:1512-1516
    • (1992) J Clin Invest , vol.89 , pp. 1512-1516
    • Sandy, J.D.1    Flannery, C.R.2    Neame, P.J.3    Lohmander, L.S.4
  • 42
    • 0027030103 scopus 로고
    • Synthetic inhibitors of bacterial and mammalian interstitial collagenases
    • Ellis GP, Luscombe DK (eds) Elsevier, Amsterdam
    • Schwartz MA, Van Wart HE (1992) Synthetic inhibitors of bacterial and mammalian interstitial collagenases. In: Ellis GP, Luscombe DK (eds) Progress in medicinal chemistry, Elsevier, Amsterdam, pp 1124-1131
    • (1992) Progress in Medicinal Chemistry , pp. 1124-1131
    • Schwartz, M.A.1    Van Wart, H.E.2
  • 44
    • 0027448327 scopus 로고
    • Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391
    • Seed MP, Ismaiel S, Cheung CY, Thomson TA, Gardner CR, Atkins RM, Elson CJ (1993) Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391. Ann Rheum Dis 52:37-43
    • (1993) Ann Rheum Dis , vol.52 , pp. 37-43
    • Seed, M.P.1    Ismaiel, S.2    Cheung, C.Y.3    Thomson, T.A.4    Gardner, C.R.5    Atkins, R.M.6    Elson, C.J.7
  • 45
    • 0026131346 scopus 로고
    • Purified staphylococcal culture medium stimulates neutral metalloprotease secretion from human articular cartilage
    • Williams RJ, Smith RL, Schurman DJ (1991) Purified staphylococcal culture medium stimulates neutral metalloprotease secretion from human articular cartilage. J Orthop Res 9:258-265
    • (1991) J Orthop Res , vol.9 , pp. 258-265
    • Williams, R.J.1    Smith, R.L.2    Schurman, D.J.3
  • 46
    • 0029891449 scopus 로고    scopus 로고
    • Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 receptor shedding and TNF alpha processing in RA synovial membrane cell cultures
    • Williams LM, Gibbons DL, Gearing A, Maini RN, Feldmann M, Brennan FM (1996) Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 receptor shedding and TNF alpha processing in RA synovial membrane cell cultures. J Clin Invest 97:2833-2841
    • (1996) J Clin Invest , vol.97 , pp. 2833-2841
    • Williams, L.M.1    Gibbons, D.L.2    Gearing, A.3    Maini, R.N.4    Feldmann, M.5    Brennan, F.M.6
  • 47
    • 0025847582 scopus 로고
    • Matrix metalloproteinases and their inhibitors in connective tissue remodeling
    • Woessner JF Jr (1991) Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145-2154
    • (1991) FASEB J , vol.5 , pp. 2145-2154
    • Woessner Jr., J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.