Environmental lead exposure induces changes in the heme biosynthetic pathway

Environmental Toxicology and Water Quality

Volumn 12, Issue 3, 1997, Pages 245-248

  Ho, John W ^a   Ho, Alex W ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Erythrocyte; Heme; Lead; Metabolite; Microscreening test; Porphyrins; Toxicity

Indexed keywords

ERYTHROCYTE PROTOPORPHYRIN; HEME; LEAD; PORPHYRIN;

ARTICLE; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HEME SYNTHESIS; HUMAN; LEAD BLOOD LEVEL; LEAD POISONING; MALE; METABOLITE; PRIORITY JOURNAL; SCREENING TEST;

EID: 0030812512     PISSN: 10534725     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2256(1997)12:3<245::AID-TOX7>3.0.CO;2-8     Document Type: Article

References (13)

1. Bush, B., D. R. Doran, and K. W. Jackson. 1982. Evaluation of erythrocyte protoporphyrin and zinc protoporphyrin as micro screening procedures for lead poisoning detection. Ann. Clin. Biochem. 19:71-76.
2. Guthrie, R., and A. L. Susi. 1963. A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants. Pediatrics 32:338-343.
3. Hessel, D. W. 1986. A simple and rapid quantitative determination of lead in blood. Atomic Absorp. Newslett. 7:55-57.
4. Ho, J. W., R. Guthrie, and H. Tieckelmann. 1987. Quantitative determination of porphyrins, their precursors and zinc protoporphyrin in whole blood and dried blood by HPLC with fluorimetric detection. J. Chromatogr. 417:269-276.
5. Joselow, M. M., and J. Flores. (1977). Application of the ZPP test as a monitor of occupational exposure to lead. Am. Indust. Hygiene. Assoc. J. 38:63-66.
6. Labbe, R. F., and R. L. Rettmer. 1989. Zinc protoporphyrin: A product of iron-deficiency erythropoiesis. Sem. Hematol. 26:40-46.
7. Labbe, R. F. 1992. Clinical utility of zinc protoporphyrin. Clin. Chem. 38:2167-2168.
8. Lamola, A. A., and Yamae, T. 1974. Zinc protoporphyrin in the erythrocytes of patients with lead intoxication and iron deficiency anemia. Science 186:936-938.
9. Landrigan, P. J., and J. W. Graef. 1987. Pédiatrie lead poisoning in 1987: The epidemic continues. 79:582-583.
10. Lerner, S., P. Gartside, and B. Roy. 1982. Studies in lead poisoning. Am. Ind. Hyg. Assoc. J. 43:516-519.
11. Orfanos, A. P., W. H. Murphey, and R. Guthrie. 1977. FEP screening test. J. Lab. Clin. Med. 89:659-665.
12. Piomelli, S. 1977. Free erythrocyte porphyrins in the detection of undue absorption of Pb and of Fe deficiency. Clin. Chem. 23:264-269.
13. Westerlund-Helmerson, U. 1970. A method for plasma lead determination by atomic absorption spectrophotometry. Atomic Absorp. Newslett. 9:133-135.