Denitrosation of 1,3-dimethyl-2-cyano-1-nitrosoguanidine in rat primary hepatocyte cultures

Biochemical Pharmacology

Volumn 53, Issue 9, 1997, Pages 1297-1306

  Jensen, David E ^a,b   Belka, George K ^a   Dworkin, Chaim ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Denitrosation; Glutathione transferase; N nitrosoguanidinium compounds; Nitric oxide; Nitrosoglutathione; Rat primary hepatocyte cultures

Indexed keywords

1,3 DIMETHYL 2 CYANO 1 NITROSOGUANIDINE; AZO DYE; BUTHIONINE SULFOXIMINE; ETACRYNIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; MALEIC ACID DIETHYL ESTER; MERCURIC CHLORIDE; NITROSOGUANIDINE; S NITROSOGLUTATHIONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; LIVER; NITROSATION; NITROSOGUANIDINES; RATS;

EID: 0030812312     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00861-1     Document Type: Article

References (25)

1. Jensen DE, Denitrosation as a determinant of nitrosocimetidine in vivo activity. Cancer Res 43: 5258-5267, 1983.
2. Jensen DE, Stelman GJ and Spiegel A, Species differences in blood-mediated nitrosocimetidine denitrosation. Cancer Res 47: 353-359, 1987.
3. Kawachi T, Kogure K, Kamijo Y and Sugimura T, The metabolism of N-methyl-N′-nitro-N-nitrosoguanidine in rats. Biochim Biophys Acta 222: 409-415, 1970.
4. Sugimura T and Kawachi T, Experimental stomach cancer. Methods Cancer Res 7: 245-308, 1973.
5. Jensen DE and Mackay RL, Rat, mouse and hamster isozyme specificity in the glutathione transferase-mediated denitrosation of nitrosoguanidinium compounds. Cancer Res 50: 1440-1448, 1990.
6. Jensen DE and Stelman GJ, Evidence for cytosolic glutathione transferase-mediated denitrosation of nitrosocimetidine and 1-methyl-2-nitro-1-nitrosoguanidine. Carcinogenesis 8: 1791-1800, 1987.
7. Jensen DE and Belka GK, Enzymic denitrosation of 1,3-dimethyl-2-cyano-1-nitrosoguanidine in rat liver cytosol and the fate of the immediate product S-nitrosoglutathione. Biochem Pharmacol 53: 0000-0000, 1997.
8. 2 reaction. Chem Res Toxicol 7: 519-525, 1994.
9. Stamler JS, Singel DJ and Loscalzo J, Biochemistry of nitric oxide and its redox-activated forms. Science 258: 1898-1902, 1992.
10. Stamler JS, Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell 78: 931-936, 1994.
11. Seglen PO, Preparation of isolated rat liver cells. Methods Cell Biol 13: 29-83, 1976.
12. Bonney RJ, Walker PR and Potter VR. Isozyme patterns in parenchymal and non-parenchymal cells isolated from regenerating and regenerated rat liver. Biochem J 136: 947-954, 1973.
13. Stolzenbach F, Lactic dehydrogenases (crystalline). Methods Enzymol 9: 278-288, 1966.
14. Tietze F, Enzymic method for quantitative determination of nonogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem 27: 502-522, 1969.
15. Yamamoto K and Farber JL, Metabolism of pyridine nucleotides in cultured rat hepatocytes intoxicated with tert-butyl hydroperoxide. Biochem Pharmacol 43: 1119-1126, 1992.
16. Jensen DE, Stelman GJ and Williams AW, Microsomally-mediated denitrosation of nitrosoguanidinium compounds. Carcinogenesis 11: 1075-1082, 1990.
17. Boyland E and Chasseaud LF, Enzyme-catalysed conjugations of glutathione with unsaturated compounds. Biochem J 104: 95-102, 1967.
18. Plummer JL, Smith BR, Sies H and Bend JR, Chemical depletion of glutathione in vivo. Methods Enzymol 77: 50-59, 1981.
19. Meredith MJ and Reed DJ, Status of the mitochondrial pool of glutathione in the isolated hepatocyte. J Biol Chem 257: 3747-3753, 1982.
20. Meister A, Selective modification of glutathione metabolism. Science 220: 472-477, 1983.
21. Ahokas JT, Micholls FA, Ravenscroft PJ and Emmerson BT, Inhibition of purified rat liver glutathione S-transferase isozymes by diuretic drugs. Biochem Pharmacol 34: 2157-2161, 1985.
22. Ploemen JHTM, Van Ommen B, Bogaards JJP and Van Bladeren PJ, Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases. Xenobiotica 23: 913-923, 1993.
23. Mannervik B, Alin P, Guthenberg C, Jensson H, Tahir MK, Warholm M and Jomvall H, Identification of three classes of cytosolic glutathione transferase common to several mammalian species: Correlation between structural data and enzymatic properties. Proc Natl Acad Sci USA 82: 7202-7206, 1985.
24. Meloche BA and O'Brien PJ, S-Nitrosyl glutathione-mediated hepatocyte cytotoxicity. Xenobiotica 23: 863-871, 1993.
25. Saville B, A scheme for the colorimetric determination of microgram amounts of thiols. Analyst 83: 670-672, 1958.