Metastatic adenocarcinoma to the brain: An immunohistochemical approach

Human Pathology

Volumn 28, Issue 8, 1997, Pages 938-943

  Perry, Arie ^a   Parisi, Joseph E ^a   Kurtin, Paul J ^a  

^a MAYO CLINIC   (United States)

Author keywords

Adenocarcinoma; Brain metastases; Cytokeratins; Immunohistochemistry; Tumor of unknown origin

Indexed keywords

CELL ADHESION MOLECULE; CYTOKERATIN; ESTROGEN RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; KERATIN; PROGESTERONE RECEPTOR;

ARTICLE; BRAIN METASTASIS; BREAST CARCINOMA; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; MAJOR CLINICAL STUDY;

EID: 0030812223     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(97)90009-5     Document Type: Article

References (33)

1. Loy TS, Calaluce RD: Utility of cytokeratin immunostaining in separating pulmonary adenocarcinomas from colonic adenocarcinomas. Am J Clin Pathol 102:764-767, 1994
2. Miettinen M: Keratin immunohistochemistry: Update of applications and pitfalls. Pathol Annu 28:113-143, 1993
3. Guerrieri C, Frånlund B, Boeryd B: Expression of cytokeratin 7 in simultaneous mucinous tumors of the ovary and appendix. Mod Pathol 8:573-576, 1995
4. Ueda G, Sawada M, Ogawa H, et al: Immunohistochemical study of cytokeratin 7 for the differential diagnosis of adenocarcinomas in the ovary. Gynecol Oncol 51:219-223, 1993
5. Ramaekers F, van Niekerk C, Poels L, et al: Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas. Am J Pathol 136:641-655, 1990
6. Moll R, Franke WW, Schiller DL: The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11-24, 1982
7. Ascoli V, Taccogna S, Scalzo CC, et al: Utility of cytokeratin 20 in identifying the origin of metastatic carcinomas in effusions. Diagn Cytopathol 12:303-308, 1995
8. Moll I, Kuhn C. Moll R: Cytokeratin 20 is a general marker of cutaneous Merkel cells while certain neuronal proteins are absent. J Invest Dermatol 104:910-915, 1995
9. Moll R, Zimbelmann R, Goldschmidt MD, et al: The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. Differentiation 53:75-93, 1993
10. Moll R, Löwe A, Laufer J, Franke WW: Cytokeratin 20 in human carcinomas: A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 140:427-447, 1992
11. Salvati M, Cervoni L, Raco A: Single brain metastases from unknown primary malignancies in CT-era. J Neuro-Oncol 23:75-80, 1995
12. Perry A, White C: Biopsies of metastatic neoplasms in central nervous system: The surgical pathologist's perspective. Brain Pathol 4:435, 1994
13. Debevec M: Management of patients with brain metastases of unknown origin. Neoplasma 37:601-606, 1990
14. Merchutt MP: Brain metastases from undiagnosed systemic neoplasms. Arch Intern Med 149:1076-1080, 1989
15. Delattre JY. Krol G. Thaler HT, et al: Distribution of brain metastases. Arch Neurol 45:741-744, 1988
16. Chee CP, Byrnes DP: Cases of brain metastasis presenting as the first sign of systemic cancer. Singapore Med J 29:252-256, 1988
17. Le Chevalier T, Smith FP, Caille P, et al: Sites of primary malignancies in patients presenting with cerebral metastases: A review of 120 cases. Cancer 56:880-882, 1985
18. White KT, Fleming TR, Laws ER Jr: Single metastasis to the brain: Surgical treatment in 122 consecutive patients. Mayo Clin Proc 56:424-428, 1981
19. Mackay B, Ordonez NG: Pathological evaluation of neoplasms with unknown primary tumor site. Semin Oncol 20:206-228, 1993
20. Le Chevalier T, Cvitkovic E, Caille P, et al: Early metastatic cancer of unknown primary origin at presentation: A clinical study of 302 consecutive autopsied patients. Arch Intern Med 148:2035-2039, 1988
21. Graf A-H, Buchberger W, Langmayr H, et al: Site preference of metastatic tumours of the brain. Virchows Arch A 412:493-498, 1988
22. Cosgrove M, Fitzgibbons PL, Sherrod A, et al: Intermediate filament expression in astrocytic neoplasms. Am J Surg Pathol 13:141-145, 1989
23. Haagensen DE Jr, Dilley WG, Mazoujian G, et al: Review of GCDFP-15: An apocrine marker protein (review). Ann N Y Acad Sci 586:161-173, 1990
24. Mazoujian G, Bodian C, Haagensen DE, et al: Expression of GCDFP-15 in breast carcinomas: Relationship to pathologic and clinical factors. Cancer 63:2156-2161, 1989
25. Mazoujian G, Margolis R: Immunohistochemistry of gross cystic disease fluid protein (GCDFP-15) in 65 benign sweat gland tumors of the skin. Am J Dermatopathol 10:28-35, 1988
26. Mazoujian G, Warhol MJ, Haagensen DE Jr: The ultrastructural localization of gross cystic disease fluid protein (GCDFP-15) in breast epithelium. Am J Pathol 116:305-310, 1984
27. Swanson PE, Pettinato G, Lillemoe TJ, et al: Gross cystic disease fluid protein-15 in salivary gland tumors. Arch Pathol Lab Med 115:158-163, 1991
28. Wick MR, Lillemoe TJ, Copland GT, et al: Gross cystic disease fluid protein-15 as a marker for breast cancer: Immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin. HUM PATHOL 20:281-287, 1989
29. Raab SS, Berg LC, Swanson PE, et al: Adenocarcinoma in the lung in patients with breast cancer: A prospective analysis of the discriminatory value of immunohistology. Am J Clin Pathol 100:27-35, 1993
30. Akasofu M, Kawahara E, Kurumaya H, et al: Immunohistochemical detection of breast specific antigens and cytokeratins in metastatic breast carcinoma in the liver. Acta Pathol Jpn 43:736-744, 1993
31. Monteagudo C, Merino MJ, LaPorte N, et al: Value of gross cystic disease fluid protein-15 in distinguishing metastatic breast carcinomas among poorly differentiated neoplasms involving the ovary. HUM PATHOL 22:368-372, 1990
32. Ormsby AH, SnowJL, Su WPD, et al: Diagnostic immunohistochemistry of cutaneous metastatic breast carcinoma: A statistical analysis of the utility of gross cystic disease fluid protein-15 and estrogen receptor protein. J Am Acad Dermatol 32:711-716, 1995
33. Chaubert P, Hurlimann J: Mammary origin of metastases: Immunohistochemical determination. Arch Pathol Lab Med 116:1181-1188, 1992