The methodology and scope of human microneurography

Journal of Neuroscience Methods

Volumn 74, Issue 2, 1997, Pages 123-136

  Gandevia, S C ^a   Hales, J P ^a  

^a NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

Author keywords

Amplifier; Cutaneous afferents; Human; Motor control; Muscle afferents; Pain; Sympathetic outflow

Indexed keywords

ARTICLE; CAT; FACIAL NERVE; HUMAN; MICROELECTRODE; MOTOR COORDINATION; MOTOR PERFORMANCE; MUSCLE SPINDLE AFFERENT NERVE; NEUROGRAPHY; NONHUMAN; PAIN; PRIORITY JOURNAL; SOMATOSENSORY SYSTEM; SYMPATHETIC INNERVATION;

ACTION POTENTIALS; AMPLIFIERS; HUMANS; MICROELECTRODES; NERVE FIBERS; NEURONS;

EID: 0030811682     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(97)02243-7     Document Type: Article

References (90)

1. Adriaensen, H., Gybels, J., Handwerker, H.O. and Van Hees, J. (1983) Response properties of thin myelinated (A-delta) fibres in human skin nerves, J. Neurophysiol., 49: 111-122.
2. Adriaensen, H., Gybels, J., Handwerker, H.O. and Van Hees, J. (1984) Nociceptor discharges and sensations due to prolonged noxious mechanical stimulation - a paradox, Hum. Neurobiol., 3: 53-58.
3. Anderson, E.A., Sinkey, C.A., Clary, M., Kempf, J. and Mark, A.L. (1989) Survey of symptoms experienced after microneurographic recording, Acta Physiol. Scand., 136 (Suppl. 584): 3.
4. Brink, E.E. and Mackel, R.G. (1993) Time course of action potentials recorded from single human afferents, Brain, 116: 415-432.
5. Burke, D. (1981) The activity of human muscle spindle endings in normal motor behavior. In R. Portor (Ed.) International Review of Physiology, Vol. 25, Neurophysiology IV, University Park Press, Baltimore, pp. 91-126.
6. Burke, D. (1997) Unit identification, sampling bias and technical issues in microneurographic recordings from muscle spindle afferents, J. Neurosci. Methods, 74: 137-144.
7. Burke, D., Aniss, A.M. and Gandevia, S.C. (1987) In-parallel and in-series behavior of human muscle spindle endings, J. Neurophysiol., 58: 417-426.
8. Burke, D., Gandevia, S.C. and Macefield, G. (1988) Responses to passive movement of receptors in joint, skin and muscle of the human hand, J. Physiol., 402: 347-361.
9. Calancie, B.M. and Stein, R.B.(1988) Microneurography for the recording and selective stimulation of afferents: an assessment, Muscle Nerve, 11: 638-644.
10. David, G., Barrett, J.N. and Barrett, E.F. (1993) Activation of internodal potassium conductance in rat myelinated axons, J. Physiol., 472: 177-202.
11. Eckberg, D.L., Wallin, B.G., Fagius, J., Lundberg, L. and Torebjörk, H.E. (1989) Prospective study of symptoms after human microneurography, Acta Physiol. Scand, 137: 567-569.
12. Edin, B.B. (1990) Finger joint movement sensitivity of non-cutaneous mechanoreceptor afferents in the human radial nerve, Exp. Brain Res., 82: 417-422.
13. Edin, B.B., Bäckström, P.A. and Bäckström, L.O. (1988) Single unit retrieval in microneurography: a microprocessor-based device controlled by an operator, J. Neurosci. Methods, 24: 137-144.
14. Edin, B.B., Essick, G.K., Trulsson, M. and Olsson, K.A. (1995) Receptor encoding of moving tactile stimuli in humans I: temporal pattern of discharge of individual low-threshold mechanoreceptors, J. Neurosci., 15: 830-847.
15. Edin, B.B. and Vallbo, Å.B. (1987) Twitch contraction for identification of human muscle afferents, Acta Physiol. Scand., 131: 129-138.
16. Edin, B.B. and Vallbo, Å.B. (1990) Classification of human muscle stretch receptor afferents: a Bayesian approach, J. Neurophysiol., 63: 1314-1322.
17. Fried, K., Frizén, J. and Mozart, M. (1989) De- and re-generation of axons after minor lesions in the rat sciatic nerve: effects of microneurography electrode penetrations, Pain, 36: 93-102.
18. Forster, C. and Handwerker, H.O. (1990) Automatic classification and analysis of microneurographic spike data using a RC/AT, J. Neurosci. Methods, 31: 109-118.
19. Gandevia, S.C. (1985) Illusory movements produced by electrical stimulation of low-threshold muscle afferents from the hand, Brain, 108: 965-981.
20. Gandevia, S.C. (1996) Kinesthesia: roles for afferent signals and motor commands. In Rowell L.B. and Shepherd J.T. (Eds.), Handbook on Integration of Motor, Circulatory, Respiratory and Metabolic Control during Exercise, American Physiological Society, pp. 128-172.
21. Gandevia, S.C. and Burke, D. (1992) Does the nervous system depend on kinesthetic information to control natural limb movements? Behav. Brain Sci., 15: 614-632.
22. Gandevia, S.C., Burke, D. and McKeon, B. (1984) The projection of muscle afferents from the hand to cerebral cortex in man, Brain, 107: 1-13.
23. Gandevia, S.C., Macefield, G., Burke, D. and McKenzie, D.K. (1990) Voluntary activation of human motor axons in the absence of muscle afferent feedback: the control of the deafferented hand, Brain, 113: 1563-1581.
24. Hagbarth, K.-E. (1979) Exteroceptive, proprioceptive, and sympathetic activity recorded with microelectrodes from human peripheral nerves, Mayo Clin. Proc., 54: 353-365.
25. Hagbarth, K.-E. (1993) Microneurography and applications to issues of motor control, Muscle Nerve, 16: 693-705.
26. Hagbarth, K.-E. and Vallbo, Å.B. (1967) Mechanoreceptor activity recorded percutaneously with semi-microelectrodes in human peripheral nerves, Acta Physiol. Scand., 69: 121-122.
27. Hagbarth, K.-E. and Vallbo, Å.B. (1968a) Discharge characteristics of human muscle afferents during muscle stretch and contraction, Exp. Neurol., 22: 674-694.
28. Hagbarth, K.-E. and Vallbo, Å.B. (1968b) Pulse and respiratory grouping of sympathetic impulses in human muscle nerves, Acta Physiol. Scand., 74: 96-108.
29. Hallin, R.G. (1990) Microneurography in relation to intraneural topography: somatotopic organisation of median nerve fascicles in humans, J. Neurol. Neurosurg. Psychiat., 53: 736-744.
30. Hallin, R.G., Ekedahl, R. and Frank, O. (1994) Electrophysiological evidence of Ranvier node clustering in human sensory nerve fascicles, Somatosens. Mot. Res., 11: 295-304.
31. Hallin, R.G. and Torebjörk, H.-E. (1974) Single unit sympathetic activity in human skin nerves during rest and various manoeuvres, Acta Physiol. Scand., 92: 303-317.
32. Hallin, R.G. and Wiesenfeld, Z. (1981) A standardized electrode for percutaneous recording of A and C fibre units in conscious man, Acta Physiol. Scand., 113: 561-563.
33. Hallin, R.G., Wiesenfeld-Hallin, Z. and Duranti, R. (1986) Percutaneous microneurography in man does not cause pressure block of almost all axons the impaled nerve fascicle, Neurosci. Lett., 68: 356-361.
34. Handwerker, H.O., Forster, C. and Kirchhoff, C. (1991) Discharge patterns of human C-fibers induced by itching and burning stimuli, J. Neurophysiol., 66: 307-315.
35. Hulliger, M., Nordh, E., Thelin, A.-E. and Vallbo, Å.B. (1979) The responses of afferent fibres from the glabrous skin of the hand during voluntary finger movements in man, J. Physiol. Lond., 291: 233-249.
36. Inglis, J.T., Leeper, J.B., Burke, D. and Gandevia, S.C. (1996) Morphology of action potentials recorded from human nerves using microneurography, Exp. Brain Res., 110: 308-314.
37. Johansson, R.S., Trulsson, M., Olsson, K.Å. and Abbs, J.H. (1988a) Mechanoreceptive afferent activity in the infraorbital nerve in man during speech and chewing movements, Exp. Brain Res., 72: 209-214.
38. Johansson, R.S., Trulsson, M., Olsson, K.Å. and Westberg, K.G. (1988b) Mechanoreceptor activity from the human face and oral mucosa, Exp. Brain Res., 72: 204-208.
39. Johansson, R.S. and Vallbo, Å.B. (1979) Tactile sensibility in the human hand: relative and absolute densities of four types of mechanoreceptive units in glabrous skin, J. Physiol. Lond., 286: 282-300.
40. Jorum, E., Lundberg, L.E. and Torebjörk, H.E. (1989) Peripheral projections of nociceptive unmyelinated axons in the human peroneal nerve, J. Physiol. Lond., 416: 291-301.
41. Kakuda, N. (1992) Conduction velocity of low-threshold mechanoreceptive afferent fibers in the glabrous and hairy skin of human hands measured with microneurography and spike-triggered averaging, Neurosci. Res., 15: 179-188.
42. Katz, B. (1939) Electric excitation of nerve. Oxford University Press, London.
43. Kunesch, E., Knecht, S., Schnitzler, A., Tyercha, C., Schmitz, F. and Freund, H.-J. (1995) Somatosensory evoked potentials elicited by intraneural microstimulation of afferent nerve fibers, J. Clin. Neurophysiol., 12: 476-487.
44. Littel, E.H. (1981) After-effect of microneurography in humans, Part IV, Phys. Ther. 61: 1585-1586.
45. Macefield, V.G., Fuglevand, A.J. and Bigland-Ritchie, B. (1996) Contractile properties of single motor units in human toe extensors assessed by intraneural motor-axon stimulation, J. Neurophysiol., 75: 2599-2519.
46. Macefield, G., Gandevia, S.C. and Burke, D. (1990) Perceptual responses to microstimulation of single afferents innervating joints, muscles and skin of the human, J. Physiol., 429: 113-129.
47. Macefield, V.G., Gandevia, S.C., Bigland-Ritchie, B., Gorman, R.B. and Burke, D. (1993) The firing rates of human motoneurones voluntarily activated in the absence of muscle afferent feedback, J. Physiol. Lond., 471: 429-443.
48. Macefield, V.G., Wallin, B.G. and Vallbo, Å.B. (1994) The discharge behaviour of single vasoconstrictor motoneurones in human muscle nerves, J. Physiol., 481: 799-809.
49. Mackel, R. (1988) Conduction of neural impulses in human mechanoreceptive cutaneous afferents, J. Physiol. Lond., 401: 597-615.
50. Mackel, R. (1989) Properties of cutaneous afferents in diabetic neuropathy, Brain, 112: 1359-1376.
51. Mackel, R., Brink, E.E. and Wittkowsky, G. (1985) Properties of cutaneous mechanosensitive afferents during the early stages of regeneration in man, Brain Res., 329: 49-69.
52. Mackel, R., Kunesch, E., Waldhör, F. and Struppler, A. (1983) Reinnervation of mechanoreceptors in the human glabrous skin following peripheral nerve repair, Brain Res., 268: 49-65.
53. Marchettini, P., Cline, M. and Ochoa, J.L. (1990) Innervation territories for touch and pain afferents of single fascicles of the human ulnar nerve: mapping through intraneural microrecording and microstimulaiton, Brain, 113: 1491-1500.
54. Melzack, R. and Wall, P.D. (1962) On the nature of cutaneous sensory mechanisms, Brain, 85: 331-356.
55. McKeon, B. and Burke, D. (1980) Identification of muscle spindle afferents during in vivo recordings in man, Electroencephalogr. Clin. Neurophysiol., 48: 606-608.
56. Nordin, M. and Hagbarth, K.E. (1989) Mechanoreceptive units in the human infra-orbital nerve, Acta Physiol. Scand., 135: 149-161.
57. Ochoa, J.L. and Torebjörk, J.R. (1983) Sensations evoked by intraneural microstimulation of single mechanoreceptor units innervating the human hand, J. Physiol., 342: 633-654.
58. Ochoa, J.L. and Torebjörk, J.R. (1989) Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves, J. Physiol. Lond., 415: 583-599.
59. Rasminsky, M. and Sears, T.A. (1972) Internodal conduction in undissected demyelinated nerve fibres, J. Physiol. Lond., 227: 323-350.
60. Ribot, E., Roll, J.P. and Vedal, J.P. (1986) Efferent discharges recorded from single skeletomotor and fusimotor fibres in man, J. Physiol. Lond., 375: 251-268.
61. Rice, A.S., Andreev, N.Y. and McMahon, S.B. (1994) The consequences of microneurography electrode-induced injury of peripheral nerves observed in the rat and man, Pain, 59: 385-393.
62. Rice, A.S.C., McMahon, S.B. and Wall, P.D. (1993) The electrophysiological consequences of electrode impalement of peripheral nerves in the rat, Brain Res., 631: 221-226.
63. Schady, W., Ochoa, J.L., Torebjörk, H.E. and Chen, L.S. (1983a) Peipheral projections of fascicles in the human median nerve, Brain, 106: 745-760.
64. Schady, W.J.L. and Torebjörk, H.E. (1983) Projected and receptive fields: a comparison of projected areas of sensations evoked by intraneural stimulaiton of mechanoreceptive units, and their innervation territories, Acta Physiol. Scand., 119: 267-275.
65. Schady, W.J.L., Torebjörk, H.E. and Ochoa, J.L. (1983b) Cerebral localisation function from the input of single mechanoreceptive units in man, Acta Physiol. Scand., 119: 277-285.
66. Schmelz, M., Forster, C., Schmidt, R., Ringkamp, M., Handwerker, H.O. and Torebjörk, H.E. (1995) Delayed responses to electrical stimuli reflect C-fiber responsiveness in human microneurography, Exp. Brain Res., 104: 331-336.
67. Schmidt, R., Schmelz, M., Forster, C., Ringkamp, M., Torebjörk, E. and Handwerker, H. (1995) Novel classes of responsive and unresponsive C nociceptors in human skin, J. Neurosci., 15: 333-341.
68. Simone, D.A., Marchettini, P., Caputi, G. and Ochoa, J.L. (1994) Identification of muscle afferents subserving sensation of deep pain in humans, J. Neurophysiol., 72: 883-889.
69. Tasaki, I. (1952) Properties of myelinated fibres in frog sciatic nerve and in spinal cord as examined with microelectrodes, Jap. J. Physiol., 3: 73-94.
70. Thomas, C.K. (1995) Human motor units studied by spike-triggered averaging and intraneural motor axon stimulation. In: Gandevia, S.C., Enoka, R.M., McComas, A.J. Stuart, D.G. and Thomas, C.K., Fatigue: Neural and Muscular Mechanisms, Plenum, New York, pp. 147-160.
71. Thomas, C.K., Johansson, R.S., Westling, G. and Bigland-Ritchie, B. (1990) Twitch properties of human thenar motor units measured in response to intraneural motor axon stimulation, J. Neurophysiol., 64: 1339-1346.
72. Torebjörk, H.E. (1974) Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin, Acta Physiol. Scand., 92: 374-390.
73. Torebjörk, H.E. and Hallin, R.G. (1974) Identification of afferent C units in intact human skin nervers, Brain Res., 67 387-403.
74. Torebjörk, H.E., Hallin, R.G., Hongell, A. and Hagbarth, K.-E. (1970) Single unit potentials with complex waveform seen in microelectrode recordings from the human median nerve, Res., 24: 443-450.
75. Torebjörk, H.E. and Ochoa, J.L. (1990) New method to identify nociceptor units innervating glabrous skin of the human hand, Exp. Brain Res., 81: 509-514.
76. Torebjörk, H.E., Vallbo, Å.B. and Ochoa, J.L. (1987) Intraneural microstimulation in man. Its relation to specificity of tactile sensations, Brain, 110: 1509-1529.
77. Trulsson, M., Johansson, R.S. and Olsson, K.A. (1992) Directional sensitivity of human periodontal mechanoreceptive afferents to forces applied to the teeth, J. Physiol. Lond., 447: 373-389.
78. Vallbo, A.B. (1971a) Muscle spindle response at the onset of isometric voluntary contractions in man: time difference between fusimotor and skeletomotor effects, J. Physiol. Lond., 218: 405-431.
79. Vallbo, Å.B. (1971b) Single unit recording from human peripheral nerves: muscle receptor discharge in resting muscles and during voluntary contractions. Neurophysiology Studied in Man, International Congress Series No. 253, Excerpta Medica, Amsterdam 283-297.
80. Vallbo, Å.B. (1974) Human muscle spindle discharge during isometric voluntary contractions. Amplitude relations between spindle frequency and torque, Acta Physiol. Scand., 90: 319-336.
81. Vallbo, Å.B. (1976) Prediction of propagation block on the basis of impulse shape in sngle unit recordings from human nerves, Acta Physiol. Scand., 97: 66-74.
82. Vallbo, Å.K. and Hagbarth, K.-E. (1968) Activity from skin mechanoreceptors recorded percutaneously in awake human subjects, Exp. Neurol., 21: 270-289.
83. Vallbo, Å.B., Hagbarth, K.-E., Torebjörk, H.E. and Wallin, B.G. (1979) Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves, Physiol. Rev., 59: 919-957.
84. Vallbo, Å.K., Olsson, K.Å., Westberg, K.G. and Clark, F.J. (1984) Microstimulation of single tactile afferents from the human hand. Sensory attributes related to unit type and properties of receptive fields, Brain, 107: 727-749.
85. Vallbo, Å.K., Olsson, K.Å., Westberg, K.G. and Norrsell, U. (1993) A system of unmyelinated afferents for innocuous mechanoreception in the human skin, Brain Res., 628: 301-304.
86. Van Hees, J. and Gybels, J. (1972) Pain related to single afferent C-fibers from human skin, Brain Res., 48: 397-400.
87. Wall, P.D. and McMahon, S.B. (1985) Microneurography and its relation to perceived sensation: a . review, Pain, 21: 209-229.
88. Westling, G., Johansson, R.S., Thomas, C.K. and Bigland-Ritchie, B. (1990) Measurement of contractile and electrical properties of single human thenar motor units in response to intraneural motor axon stimulation, J. Neurophysiol., 64: 1331-1338.
89. Wilson, L.R., Gandevia, S.C. and Burke, D. (1995) Increased resting discharge of human spindle afferents following voluntary contractions, J. Physiol. Lond., 488: 833-840.
90. Woodbury, J.W. (1952) Direct membrane resting and action potentials from single myelinated fibres, Cell Comp. Physiol., 39: 323-339.