Effect of acute acipimox administration on the rates of lipid and glycogen synthesis in cachectic tumor-bearing rats

Nutrition and Cancer

Volumn 28, Issue 1, 1997, Pages 100-106

  Obeid, Omar A ^a   Emery, Peter W ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACIPIMOX; CARBON 13; GLYCEROL; GLYCOGEN; LIPID; NICOTINIC ACID DERIVATIVE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CACHEXIA; CONTROLLED STUDY; DRUG EFFECT; FATTY ACID SYNTHESIS; GLUCONEOGENESIS; GLYCOGEN SYNTHESIS; LEYDIG CELL TUMOR; LIPOGENESIS; LIPOLYSIS; MALE; NONHUMAN; RAT; TEST MEAL;

ANIMALIA; TRITIUM;

EID: 0030811598     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635589709514559     Document Type: Article

References (28)

1. Obeid, OA, and Emery, PW: "Lipid metabolism in cachectic tumor-bearing rats at different stages of tumor growth." Nutr Cancer 19, 87-98, 1993.
2. Emery, PW, Carpenter, TTA, and Obeid, OA: "Alterations in postprandial glycogen and lipid synthesis in cachectic tumor-bearing rats." Nutr Cancer 20, 231-240, 1993.
3. Fanelli, C, Calderone, S, Epifano, L, De Vincenzo, A, Modarelli, F, et al.: "Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans." J Clin Invest 92, 1617-1622, 1993.
4. Fuccella, LM, Goldaniga, G, Lovisolo, P, Maggi, E, Musatti, L, et al.: "Inhibition of lipolysis by nicotinic acid and by acipimox." Clin Pharmacol Ther 28, 790-795, 1980.
5. Fulcher, GR, Walker, M, Catalano, C, Agius, L, and Alberti, KGMM: "Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects." Diabetes 41, 1400-1408, 1992.
6. Obeid, OA, Bell, JD, and Emery, PW: "The effect of acute acipimox administration on the contribution of different pathways to postprandial glycogen synthesis in cachectic tumour-bearing rats" (abstr). Proc Nutr Soc 56, 170A, 1996.
7. Bernhart, F, and Tomarelli, R: "A salt mixture supplying the National Research Council estimates of the mineral requirement of the rat." J Nutr 89, 495-500, 1966.
8. Naismith, DJ, Akinyanju, P, and Yudkin, J: "Influence of caffeine containing beverages on the growth, food utilisation and plasma lipid of the rat." J Nutr 97, 375-381, 1969.
9. Cooke, BA, Lindh, LM, Janszen, FHA, van Driel, MJA, Bakker, CP, et al.: "A Leydig cell tumour, a model for the study of lutropin." Biochim Biophys Acta 583, 320-331, 1979.
10. Levine, JA, and Emery, PW: "The significance of learned food aversions in the aetiology of anorexia associated with cancer." Br J Cancer 56, 73-78, 1987.
11. Obeid, OA, and Emery, PW: "Changes in feeding behaviour in cachectic tumour bearing rats during the period of tumour growth" (abstr). Proc Nutr Soc 51, 122A, 1992.
12. Wolfe, RR: Tracers in Metabolic Research: Radioisotope and Stable Isotope/Mass Spectrometry Methods. New York: Liss, 1984, vol 9.
13. Morris, DL: "Quantitative determination of carbohydrate with Dreywood's anthrone reagent." Science 107, 245-255, 1948.
14. 13C nuclear magnetic resonance analysis." Metabolism 43, 38-43, 1994.
15. Kuwajima, M, Golden, S, Katz, J, Unger, RH, Foster, D, et al.: "Active hepatic glycogen synthesis from gluconeogenesis precursors despite high tissue levels of fructose 2,6-biphosphate." J Biol Chem 261, 2632-2637, 1986.
16. Vaag, A, Skott, P, Damsbo, P, Gall, M-A, Richter, EA, et al.: "Effect of the antilipolytic nicotinic acid analogue acipimox on whole body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus." J Clin Invest 88, 1282-1290, 1991.
17. Matthews, DC, Obeid, OA, and Emery, PW: "The effect of inhibiting gluconeogenesis on the synthesis of glycogen and lipid in cachectic tumour bearing rats" (abstr). Proc Nutr Soc 50, 140A, 1991.
18. Tayek, JA, Sutter, L, Manglik, S, Lillington, LB, Grosvenor, M, et al.: "Altered metabolism and mortality in patients with colon cancer receiving chemotherapy." Am J Med Sci 310, 48-55, 1995.
19. Legaspi, A, Jeevanandam, M, Starnes, HF, and Brennan, MF: "Whole body lipid and energy metabolism in the cancer patient." Metabolism 36, 958-963, 1987.
20. Spiegel, RJ, Schaefer, EJ, Magrath, IT, and Edwards, BK: "Plasma lipid alterations in leukemia and lymphoma." Am J Med 72, 775-782, 1982.
21. Dilman, VM, Berstein, LM, Ostroumova, MN, Tsyrlina, YV, and Golubev, AG: "Peculiarities of hyperlipidaemia in tumour patients." Br J Cancer 43, 637-643, 1981.
22. Semb, H, Peterson, J, Tavernier, J, and Olivecrona, T: "Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo." J Biol Chem 262, 8390-8394, 1987.
23. Gold, J: "Use of hydrazine sulfate in terminal and preterminal cancer patients: Results of investigational new drug (IND) study in 84 evaluable patients." Oncology 32, 1-10, 1975.
24. Gold, J: "Hydrazine sulfate in the treatment of cancer." Cancer Treat Rep 60, 964-965, 1976.
25. Chlebowski, RT, Heber, D, Richardson, B, and Block, JB: "Influence of hydrazine sulfate on abnormal carbohydrate metabolism in cancer patients with weight loss." Cancer Res 44, 857-861, 1984.
26. Chlebowski, RT, Bulcavage, L, Grosvenor, M, Tsunokai, R, Block, JB, et al.: "Hydrazine sulfate in cancer patients with weight loss: a placebo-controlled clinical experience." Cancer 59, 406-410, 1987.
27. Chlebowski, RT, Bulcavage, L, Grosvenor, M, Oktay, E, Block, JB, et al.: "Hydrazine sulfate influence on nutritional status and survival in non-small cell lung cancer." J Clin Oncol 8, 9-15, 1990.
28. Filov, VA, Gershanovich, ML, Danova, LA, and Ivin, BA: "Experience of the treatment with Sehydrin (hydrazine sulfate, HS) in the advanced cancer patient." Invest New Drugs 13, 89-97, 1995.