A new synthetic lipid A analog, ONO-4007, stimulates the production of tumor necrosis factor-α in tumor tissues, resulting in the rejection of transplanted rat hepatoma cells

Anti-Cancer Drugs

Volumn 8, Issue 5, 1997, Pages 500-508

  Kuramitsu, Yasuhiro ^a   Nishibe, Manabu ^a   Ohiro, Youichi ^a   Matsushita, Kazuhiro ^a   Yuan, Lan ^a   Obara, Manabu ^a   Kobayashi, Masanobu ^a   Hosokawa, Masuo ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Hepatocellular carcinoma; Lipid A; Lipopolysaccharide; Tumor necrosis factor

Indexed keywords

2 DEOXY 3 O (9 PHENYLNONANOYL) 2 [3 (9 PHENYLNONANOYLOXY)TETRADECANOYLAMINO]GLUCOPYRANOSE 4 SULFATE; ANTINEOPLASTIC AGENT; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LIPID A DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER TRANSPLANTATION; CYTOPATHOGENIC EFFECT; DRUG EFFECT; DRUG SYNTHESIS; FEMALE; FIBROSARCOMA; GROWTH INHIBITION; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RAT;

EID: 0030811205     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199706000-00013     Document Type: Article

References (24)

1. Morrison DC, Ryan JL. Endotoxins and disease mechanisms. Annu Rev Med 1983; 38: 417-32.
2. Tobias PS, Soldau K, Ulevitch RJ. Isolation of lipopolysaccharide-binding acute phase reactant from rabbit serum. J Exp Med 1986; 164: 777-93.
3. Satoh M, Inagawa H, Shimada Y, Soma G, Oshima H, Mizuno D. Endogenous production of tumor necrosis factor in normal mice and human cancer patients by interferons and other cytokines combined with biological response modifiers of bacterial origin. J Biol Response Mod 1987; 6: 512-24.
4. Yamazaki M, Okutomi T. Augmentation of cytotoxin from murine bone marrow and peritoneal macrophages by tumor transplantation. Cancer Res 1989; 49: 352-6.
5. Kusama T, Soga T, Ono Y, et al. Synthesis and biological activities of lipid A analogs: modification of a glycosidically bound group with chemically stable polar acidic groups and lipophilic groups on the disaccharide backbone with tetradecanoyl or N-dodecanoylglycyl groups. Chem Pharm Bull 1991; 39: 3344-53.
6. Nakatsuka M, Kumazawa Y, Homma JY, Kiso M, Hasegawa A. Inhibition in mice of experimental metastasis of B16 melanoma by the synthetic lipid-A subunit analogue GLA-60. Int J Immunopharmacol 1991; 13: 11-9.
7. Sato K, Saiki I, Yoo YC, Igarashi Y, Kiso M, Hasegawa A, Azuma I. DT-5461, a new synthetic lipid A analogue, inhibits lung and live metastasis of tumor in mice. Jpn J Cancer Res 1992; 83: 1081-7.
8. Old LJ. Tumor necrosis factor (TNF). Science 1985; 230: 630-2.
9. Yang D, Satoh M, Ueda H, Tsukagoshi S, Yamazaki M. Activation of tumor-infiltration macrophages by a synthetic lipid A analog (ONO-4007) and its implication in antitumour effects. Cancer Immunol Immunother 1994; 38: 287-93.
10. Kobayashi M, Nagayasu H, Hamada J, Takeichi N, Hosokawa M. ONO-4007, a new synthetic lipid A derivative, induces differentiation of rat myelomonocytic leukemia cells in vitro and in vivo. Exp Helatol 1994; 22: 454-9.
11. Sugiura C, Itaya T, Kondoh N, et al. Xenogenization of tumor cells by transfection with plasmid containing env gene of Friend leukemia virus. Jpn J Cancer Res 1988; 79: 1259-63.
12. Micallef M, Hosokawa M, Shibata T, et al. Immunoregulatory cytokine release in rat spleen cell cultures after treatment with bleomycin and its analogues in vivo. Cancer Immunol Immunother 1991; 33: 33-8.
13. Takeichi N, Koga Y, Fujii T, Kobayashi H. Restoration of T-cell function and induction of antitumor immune response in T-cell-depressed spontaneously hypertensive rats by treatment with thymosin fraction 5. Cancer Res 1985; 45: 487-91.
14. Mattews N, Neale ML. Cytotoxicity assays for tumor necrosis factor and lymphotoxin. Lymphokines and interferons. Oxford: IRL Press 1987: 221.
15. Nishida T, Nishio N, Sekiguchi Y, et al. Molecular cloning and expression of rat interleukin-1α cDNA. J Biochem 1989; 10: 351-7.
16. Mcknight AJ, Mason DW, Barclay AN. Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin 2 cDNA probe to rat MHC class II-associated invariant chain mRNA. Immunogenetics 1989; 30: 145-7.
17. McKnight AJ, Classon BJ. Biochemical and immunological properties of rat recombinant interleukin-2 and interleukin-4. Immunology 1992; 75: 286-92.
18. Northmann W, Braciak TA, Hattori M, Lee F, Fey GH. Structure of the rat interleukin-6 gene and its expression in macrophage-derived cells. J Biol Chem 1989; 264: 16072-82.
19. Goodman RE, Oblak J, Bell RG. Synthesis and characterization of rat interleukin-10 (IL-10) cDNA clones from the RNA of cultured OX8-OX-22-thoracic duct T cells. Biochem Biophys Res Commun 1992; 189: 1-7.
20. Dijkema R, van der Meide PH, Pouwels PH, Caspers M, Dubbeld M, Schellekens H. Cloning and expression of the chromosomal immune interferon gene of the rat. EMBO J 1985; 4: 761-7.
21. Shinci-Tello M, Perez-Roger I, Iwakura K, Tilzer L, Terranoma PF. Expression of tumor necrosis factor-α in the rat ovary. Endocrinology 1992; 130: 1359-64.
22. Quian SW, Kondaniiah P, Roberts AB, Sporn MB. cDNA cloning by PCR of rat transforming growth factor-β1. Nucleic Acid Res 1990; 18: 3059.
23. Gatanaga T, Noguchi K, Tanabe Y, Inagawa H, Soma G, Mizuno D. Antitumor effect of systemic administration of novel recombinant tumor necrosis factor (rTNF-S) with less toxicity than conventional r-TNF-α in vivo. J Biol Response Mod 1989; 8: 278-86.
24. Koshita Y, Itoh Y, Fujii S, et al. Mechanisms of tumor regression of TNF gene-transduced Meth-A cells transplanted in mice. Ann NY Acad Sci 1994; 716: 334-5.