High serum carcinoembryonic antigen concentration in patients with colorectal liver metastases is associated with poor cell-mediated immunity, which is predictive of survival

British Journal of Surgery

Volumn 84, Issue 10, 1997, Pages 1382-1385

  King, J ^a   Caplehorn, J R M ^b   Ross, W B ^a   Morris, D L ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN;

ADULT; AGED; ARTICLE; CELLULAR IMMUNITY; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL TIME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNITY, CELLULAR; LIVER NEOPLASMS; MALE; MIDDLE AGED; SURVIVAL ANALYSIS; SURVIVAL RATE;

EID: 0030810731     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1002/bjs.1800841013     Document Type: Article

References (22)

1. Cutait R, Alves VA, Lopes LC et al. Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and eytokeratins. Dis Colon Rectum 1991; 34: 917-20.
2. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. Carcinoembryonic antigen, a human tumour marker, functions as an intercellular adhesion molecule. Cell 1989; 57: 327-34.
3. Sener SF, Imperato JP, Chmiel J, Fremgen A, Sylvester J. The use of cancer registry data to study preoperative carcinoembryonic antigen level as an indicator of survival in colorectal cancer. CA Cancer J Clin 1989; 39: 50-7.
4. Wanebo HJ, Rao B, Pinsky CM et al. Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer. N Engl J Med 1978; 299: 448-51.
5. Hohenberger P, Schlag PM, Gerneth T, Herfath C. Pre- and postoperative carcinoembryonic antigen determinations in hepatic resection for colorectal metastases. Predictive value and implications for adjuvant treatment based on multivariate analysis. Ann Surg 1994; 219: 135-43.
6. Morris DL, Ross WB. Australian experience of cryoablation of liver tumors: metastases. Surg Oncol Clin North Am 1996; 5: 391-7.
7. Preketes AP, King J, Caplehorn JRM, Clingan PR, Ross WB, Morris DL. CEA reduction after cryotherapy for liver metastases from colon cancer hepatic metastases. Aust N Z J Surg 1994; 64: 612-14.
8. Song YQ, Ross WB, Morris DL. Prognostic value of tumour volume analysis and tumour markers in ablative treatment of colorectal cancer hepatic metastases. Aust N Z J Surg 1995; 65: 432 (Abstract).
9. Medoff JR, Jegasothy BV, Roche JK. Carcinoembryonic antigen induced release of a suppressor factor from normal human lymphocytes in vitro. Cancer Res 1984; 44: 5822-7.
10. Medoff JR, Clack VD, Roche JK. Characterisation of an immunosuppressive factor from malignant ascites that resembles a factor induced in vitro by carcinoembryonic antigen. J Immunol 1986; 137: 2057-64.
11. Tibbetts LM, Doremus CM, Tzanakakis GN, Vezeridis MP. Liver metastases with 10 human carcinoma cell lines in nude mice and association with carcinoembryonic antigen production. Cancer 1993; 71: 315-21.
12. Jessup JM, Giavazzi R, Campbell D, Cleary K, Morikawa K, Fidler IJ. Growth potential of human colorectal carcinomas in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients. Cancer Res 1988; 48: 1689-92.
13. Hostetter RB, Augustus LB, Mankarious R et al. Carcinoembryonic antigen as a selective enhancer of colorectal cancer metastasis. J Natl Cancer Inst 1990; 82: 380-5.
14. Kniker WT, Anderson CT, McBryde JL, Roumiantzeff M, Lesourd B. Multitest CMI for standardised measurement of delayed cutaneous hypersensitivity and cell-mediated immunity. Normal values and proposed scoring system for health adults in the U.S.A. Ann Allergy 1984; 52: 75-82.
15. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-81.
16. Cox DR. Regression models and life tables. J R Statist Soc 1972; 34B: 187-202.
17. Harrell FE, Lee KL. Verifying assumptions of the Cox proportional hazards model. In: Proceedings of the Eleventh Annual SAS Users Group International Conference. Atlanta, Georgia, 9-12 February 1986. Cary. North Carolina: SAS Institute, 1986: 823-8.
18. Gebski VJ, Leung OK, McNeil DR, Lunn AD. SPIDA Users Manual (Version 6). Sydney: Statistical Laboratory Macquarie University, 1992.
19. Kleinbaum DG. Survival Analysis: A Self-learning Text. New York: Springer, 1996.
20. Hayat M, Lesourd BM, Serrou B. Delayed cutaneous hypersensitivity (DCH) reactions in normal populations by multi-test: effects of sex and age. In: Medical Oncology. 5th Annual Meeting of the Medical Oncology Society, Nice. France December 1-3, 1979. Berlin: Springer, 1979: 23.
21. Anderson CT, Roumiantzeff M, Kniker WT. The Multitest system for assay of delayed cutaneous hypersensitivity (DCH) to ubiquitous antigens. J Allergy Clin Immunol 1978: 61: 167 (Abstract).
22. Lopez MJ, Robinson P, Madden T, Highbarger T. Nutritional support and prognosis in patients with head and neck cancer. J Surg Oncol 1994; 5: 33-6.