Tonic-clonic seizures: A systematic review of antiepilepsy drug efficacy and safety

Clinical Therapeutics

Volumn 19, Issue 3, 1997, Pages 433-446

  Ramsay, R Eugene ^a,b   DeToledo, John ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b International Center for Epilepsy   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; VALPROIC ACID;

ADOLESCENT; ADULT; AGED; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; GENERALIZED EPILEPSY; HUMAN; MALE; META ANALYSIS; NEUROTOXICITY; RANDOMIZED CONTROLLED TRIAL; RASH; REVIEW; TONIC CLONIC SEIZURE; TREMOR; VERTIGO;

EID: 0030810406     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(97)80128-2     Document Type: Review

References (20)

1. Dreifuss FE. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia. 1981;22: 489-501.
2. Dreifuss F. Proposal for classification of epilepsies and epileptic syndromes. Epilepsia. 1985;26:268-278.
3. Ramsay RE, Wilder BJ, Berger JR, Bruni J. A double-blind study comparing carbamazepine with phenytoin as initial seizure therapy in adults. Neurology. 1983;33: 904-910.
4. Troupin AS, Ojeman LM, Halpern L, et al. Carbamazepine - a double blind comparison with phenytoin. Neurology. 1977; 27:511-519.
5. Kosteljanetz M, Christiansen J, Mouritzen A, et al. Carbamazepine vs phenytoin: A controlled trial in focal motor and generalized epilepsy. Arch Neurol. 1979;36: 22-24.
6. Callaghan N, Kenny RA. O'Neil B, et al. A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy. J Neurol Neurosurg Psychiatry. 1985;48:639-644.
7. Crawford P, Chadwick D. A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy. J Neurol Neurosurg Psychiatry. 1986;49:1251-1257.
8. Heller AJ, Chesterman P, Elwes RDC, et al. Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: A randomised comparative monotherapy trial. J Neurol Neurosurg Psychiatry. 1995;58:44-50.
9. Mattson RH, Cramer JA, Collins JF, et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. NEJM. 1985;313:145-151.
10. Mattson RH, Cramer JA, Collins JF, and the Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. NEJM. 1992;327:765-771.
11. Ramsay RE, Wilder BJ, Murphy JV, et al. Efficacy and safety of valproic acid vs phenytoin as sole therapy for newly diagnosed primary generalized tonic-clonic seizures. J Epilepsy. 1992;5:55-60.
12. Richens A, Davidson DLW, Cartidge NEF, Easter D. A multicenter comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. J Neurol Neurosurg Psychiatry. 1994;57:682-687.
13. Shakir RA, Johnson RH, Lambie DR, et al. Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. Epilepsia. 1981;22:27-33.
14. Tallis R, Easter D. Multicenter comparative trial of valproate and phenytoin. Epilepsia. 1994;35(Suppl 7):62. Abstract.
15. Turnbull DM, Howel D, Rawlins MD, Chadwick DW. Which drug for the adult epileptic patient: Phenytoin or valproate? BMJ. 1985;290:815-819.
16. de Silva M, McArdle B, McGowan M, et al. Monotherapy for newly diagnosed childhood epilepsy: Comparative trial and prognostic evaluation. Epilepsia. 1989;30: 662. Abstract.
17. Heller AJ, Chesterman P, Elwes RDC, et al. Monotherapy for newly diagnosed adults with epilepsy: A comparative trial and prognostic evaluation. Epilepsia. 1989;30:648. Abstract.
18. Reynolds EH, Chadwick D. Valproate and carbamazepine for seizures: To the editors. NEJM. 1993;328:207-208. Letter to the editor.
19. Ramsay RE, Rowan AJ, Slater JD, et al. Effect of age on epilepsy and its treatment: Results from the VA Cooperative Study. Epilepsia. 1994;35(Suppl 8):91A. Abstract.
20. Wilder BJ, Ramsay RE, Murphy JV, et al. Comparison of valproic acid and phenytoin in newly diagnosed tonic-clonic seizures. Neurology. 1983;33:1474-1476.