c-Ha-ras transfection and expression of MDR-related genes in MCF-10A human breast cell line

Anticancer Research

Volumn 17, Issue 5 A, 1997, Pages 3587-3592

  Di Simone, Daniela ^a   Galimberti, Sara ^a   Basolo, Fulvio ^b   Ciardiello, Fortunato ^c   Petrini, Mario ^a,e   Scheper, Rik J ^d  

^a Haematology Division   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e Clinica Medica I   (Italy)

Author keywords

GST; LRP; MCF 10A; MDR; MRP; ras

Indexed keywords

CISPLATIN; DOXORUBICIN; GLUTATHIONE TRANSFERASE;

ARTICLE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MULTIDRUG RESISTANCE; ONCOGENE C H RAS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENES, MDR; GENES, RAS; GLUTATHIONE TRANSFERASE; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PROTO-ONCOGENE PROTEINS P21(RAS); TRANSFECTION; TUMOR CELLS, CULTURED; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 0030810241     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Borresen AL, Ottestad L, Gaustad A, Andersen TI, Heikkila R, Jahnsen T, Tveit KM and Nesland JM : Amplification and protein over-expression of the neu/Her-2/c-erbB-2 protooncogene in human breast carcinomas : relationship to loss of gene sequences on chromosome 17, family history and prognosis. Br J Cancer 62: 585-590, 1990.
2. Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY and Hammond D : Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313: 1111-1116, 1985.
3. Niimi S, Nakagawa K, Yokota J, Tsunokawa Y, Nishio K, Terashima Y, Shibuya M, Terada M and Saiyo N : Resistance to anticancer drugs in NIH3T3 transfected with c-myc and/or c-H-ras genes. Br J Cancer 63: 237-241, 1991.
4. Linsenmeyer ME, Jefferson S, Wolf M, Matthews JP, Broad PG and Woodcock DM: Levels of expression of the mdr1 gene and glutathione S transferase genes 2 and 3 and response to chemotherapy in multiple myeloma. Br J Cancer 65 : 471-475, 1992.
5. Petrini M, Di Simone D, Favati A, Mattii L, Valentini P and Grassi B : GST-π and P-170 co-expression in multiple myeloma. Br J Haematol 90: 393-397, 1995.
6. Burt RK, Garfield S, Johnson K and Thorgeirsson SS: Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals. Carcinogenesis 9: 2329-2332, 1988.
7. Chin KV, Ueda K, Pastan I and Gottesman MM: Modulation of activity of the promoter of the human MDR1 gene by ras and p53. Science 255: 459-462, 1992.
8. Cole SPC, Bhardwaj G, Gerlach JH, Almquist KC and Deeley RG: A novel ATP-binding cassette transporter gene overexpressed in multidrug-resistant human lung tumor cells. Proc. Am. Assoc. Cancer Res. 34: 579, 1993.
9. Flens MJ, Izquierdo MA, Scheffer GL, Fritz JM, Meijer CJLM, Scheper RJ and Zaman GJR: Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res. 54: 4557-4563, 1994.
10. Schneider E, Horton JK, Yang C-H, Nakagawa M and Cowan KH: Multidrug resistance-associated protein (MRP) gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Res. 54: 152-158, 1994.
11. Versantvoort CHM, Broxterman HJ, Bagrij T, Scheper RJ and Twentyman PR: Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein. Br. J. Cancer 72: 82-89, 1995.
12. Scheper RJ, Broxterman HJ, Scheffer GL, Kaaijk P, Dalton WS, van Heijningen THM, van Kalken CK, Slovak ML, de Vries EGE, van der Valk P, Meijer CJLM and Pinedo HM: Overexpression of a Mr 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res. 53: 1475-1479, 1993.
13. Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC and Scheper RJ: The drug resistance-related protein LRP is the human major vault protein. Nature Medicine 1: 578-582, 1995.
14. Izquierdo MA, Scheffer GL, Flens MJ, Giaccone G, Broxterman HJ, Meijer CJLM, van der Valk P and Scheper RJ: Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. Am. J. Pathol. 148: 877-888, 1996.
15. List AF, Spier CS, Grogan TM, Johnson C, Roe DJ, Greer JP, Wolff SN, Broxterman J, Scheffer GL, Scheper RJ and Dalton WS: Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood 87: 2464-2469, 1996.
16. Izquierdo MA, van der Zee AGJ, Vermorken JB, van der Valk P, Belien JAM, Giaccone G, Scheffer GL, Flens MJ, Pinedo HM, Kenemans P, Meijer CJLM, de Vries EGE and Scheper RJ: Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognosis in advanced ovarian carcinoma. J. Natl. Cancer Inst. 87: 1230-1237, 1995.
17. Panasci L, Henderson D, Torres-Garcia SJ, Skalski V, Caplan S and Hutchinson M: Transport, metabolism, and DNA interaction of melphalan in lymphocytes from patients with chronic lymphocytic leukemia. Cancer Res 48: 1972-1976, 1988.
18. Johnston JB, Israels LG, Goldenberg GJ, Anhalt CD, Verburg L, Mowat MR and Begleiter A: Glutathione S-transferase activity, sulfhydril group and glutathione levels, and DNA cross-linking activity with chlorambucil in chronic lymphocytic leukemia. J Natl Cancer Inst 82: 776-779, 1990.
19. Yang WZ, Begleiter A, Johnston JB, Israels LG and Mowat MR: Role of glutathione and glutathione S-transferase in chlorambucil resistance. Mol Pharmacol 41: 625-630, 1992.
20. Moscow JA, Fairchild CR, Madden MJ, Ransom DT, Wieand HS, O'Brien EE, Poplac DG, Cossman J, Myers CE and Cowan KH: Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumours. Cancer Res 49: 1422-1428, 1989.
21. Moffat GJ, Mc Laren AW and Roland Wolf C: Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells. J. Biol. Chem. 269: 16397-16402, 1994.
22. Soule H, Maloney T, Wolman SR, Peterson WD, Brenz R, Mac Grath CM, Russo J, Pauley RJ, Jones RF and Brooks SC: Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res. 50: 6075-6086, 1990.
23. Ciardiello F, Gottardis M, Basolo F, Pepe S, Normanno N, Dixon RB, Bianco R and Salomon DS: Additive effects of c-erbB-2, c-Ha-ras, and transforming growth factor-alpha genes on in vitro transformation of human mammary epithelial cells. Mol. Carcinog. 6: 43-52, 1992.
24. Basolo F, Elliott J, Tait J, Chen XQ, Maloney T, Russo IH, Pauley R, Momiki S, Caamano J, Klein-Szanto AJP, Koszalka M and Russo J: Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol. Carcinog. 4: 25-35, 1991.
25. Peters WHM, Boon CEW, Roelofs HMJ, Wobbes T, Nagengast FM and Kremers PG: Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa. Gastroenterology 103: 448-455, 1992.
26. Scheper RJ, Bulte JW and Baakkec JC: Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multidrug resistance. Int. J. Cancer 42: 389-394, 1988.
27. Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, Mac Donald S, Pulford KA, Stein H and Mason DY: Immunoenzimatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J. Histochem. Cytochem. 32: 219-229, 1984.
28. Fairchild CR, Ivy SP, Kao-Shanh C, Whang-Peng J, Rosen M, Israel MA, Melera PW, Cowan KH and Goldsmith MM: Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells. Cancer Res. 47: 5141-5148, 1987.
29. Tidefelt U, Elmhorn-Rosenborg A, Paul C, Hao X, Mannervik B and Eriksson LC: Expression of glutathione transferase as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia. Cancer Res. 52: 3281-3285, 1992.
30. Barrand MA, Broxterman HJ, Wroght KA, Rhodes T and Twentyman PR: Immunodetection of a 190kD protein in non-P-glycoprotein-containing MDR cells derived from small cell and non-small cell lung tumours. Br. J. Cancer 65 (suppl XVI): 21, 1995.
31. Noonan KE, Beck C, Holzmayer TA, Chin JE, Wunder JS, Andrulis IL, Gazdar AF, Wilman CL, Griffith B, von Hoff DD, Roninson IB: Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumours by polymerase chain reaction. Proc Natl Acad Sci USA 87: 7160-7164, 1990.
32. Beck J, Handgretinger R, Dopper R, Klingebield T, Niethammer D, Gekeler V: Expression of mdr1, mrp, topoisomerase IIα/ß and cyclin A in primary or relapsed states of acute lymphoblastic leukaemias. Br J Haematol 89: 356-363, 1995.
33. Hao X-Y, Widesten M, Ridderstrom M, Hellman U and Mannervik B : Co-variation of glutathione transferase expression and cytostatic drug resistance in HeLa cells: establishment of class Mu-glutathione transferase M3-3 as the dominating isoenzyme. Biochem. J. 297: 59-67, 1994.
34. Batist G, Tulpule A, Sinha BK, Katki AG, Meyers CE and Cowan KH: Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J. Biol. Chem. 261: 15544-15549, 1986.
35. Keith WN, Stallard S and Brown R: Expression of mdr 1 and gst-pi in human breast tumours : comparison to in vitro chemosensitivity. Br. J. Cancer 61: 712-716, 1992.
36. Moscow JA and Dixon KH: Glutathione and glutathione-related enzymes in multiple drug resistance. Cytotechnology 12: 155-170, 1993.
37. Okuyama T, Maehara Y, Endo K, Baba H, Adachi Y, Kuwano M and Sugimachi K: Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin. Cancer 74: 1230-1236, 1994.
38. Awasthi S, Sharma R, Singhal SS, Herzog NK, Chaubey M and Awasthi YC: Modulation of cisplatin cytotoxicity by sulphasalazine. Br. J. Cancer 70: 190-194, 1994.