Bispecific Ab therapy of B-cell lymphoma: Target cell specificity of antibody derivatives appears critical in determining therapeutic outcome

Cancer Immunology Immunotherapy

Volumn 45, Issue 3-4, 1997, Pages 171-173

  Honeychurch, Jamie ^a   Cruise, Andrew ^a   Tutt, Alison L ^a   Glennie, Martin J ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Bispecific; Immunotherapy; Lymphoma; Monoclonal antibody; Transmembrane signalling

Indexed keywords

ANTINEOPLASTIC AGENT; BISPECIFIC ANTIBODY; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; ARTICLE; B CELL LYMPHOMA; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; TARGET CELL DESTRUCTION; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODY SPECIFICITY; ANTIGENS, CD; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOTHERAPY; LYMPHOMA, B-CELL; MICE; MICE, INBRED BALB C;

EID: 0030810025     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050425     Document Type: Article

References (10)

1. Demanet C, Brissinck J, Leo O, Moser M, Thielemans K (1994) Role of T cell subsets, in the bispecific (anti-idiotype x anti-CD3) treatment of the BCLi lymphoma. Cancer Res 54:2973
2. 1, act primarily with heavy chain determinants. Hybridoma 10:219
3. 3 antibody derivatives. In: Gallagher G, Rees RC, Reynolds CW (eds) Tumour immunobiology, a practical approach. IRL Press at Oxford University Press, Oxford, p 225
4. Krop I, Fougerolles AR de, Hardy RR, Allison M, Schlissel MS, Fearon DT (1996) Self-renewal of B-1 lymphocytes is dependent on CD19. Eur J Immunol 26:238
5. Racila E, Scheuermann RH, Picker LJ, Yefenof E, Tucker T, Chang W, Marches R, Street NE, Vitetta ES, Uhr JW (1995) Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice. J Exp Med 181:1539
6. Tomonari K (1988) A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex. Immunogenetics 28:455
7. Torres RM, Law CL, Santosargumedo L, Kirkham PA, Grabstein K, Parkhouse RME, Clarke EA (1992) Identification and characterisation of the murine homolog CD22, a lymphocyte-B-restricted adhesion molecule. J Immunol 149:2641
8. Vuist WMJ, Levy R, Maloney DG (1994) Lymphoma regression induced by monoclonal anti-idiotype antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of Bcl-2 protein. Blood 83:899
9. Weiner GJ, Gast GC de (1995) Bispecific monoclonal antibody therapy of B-cell malignancy. Leukemia Lymphoma 16:199
10. Wim BM De Lau, Heije K, Neefjes JJ, Oosterwegel M, Rozemuller E, Bast BJE (1991) Absence of preferential homologous H/ L chain association in hybrid hybridomas. J Immunol 146:906