Role of gene conversion in generating polymorphisms at major histocompatibility complex loci

Hereditas

Volumn 127, Issue 1-2, 1997, Pages 97-103

  Ohta, Tomoko ^a  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMPUTER SIMULATION; DNA POLYMORPHISM; GENE CONVERSION; GENE LOCUS; GENETIC MODEL; HISTOCOMPATIBILITY GENE; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIGENE FAMILY;

EID: 0030809908     PISSN: 00180661     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1601-5223.1997.00097.x     Document Type: Article

References (19)

1. Bodmer WF, (1978). HLA: a super supergene. Harvey Lect. 72: 91-110.
2. Franklin I, and Lewontin RC, (1970), Is the gene the unit of selection? Genetics 65: 707-734.
3. Gyllensten U, Sundvall M, Ezcurra I and Erlich HA, (1991). Genetic diversity at class II DRB loci of the primate MHC. J. Immunol. 46: 4368-4376.
4. Hedrick P, (1997). Neutrality or selection? Nature 387: 138.
5. Hughes AL and Nei M, (1989). Evolution of major histocompatibility complex: Independent origin of nonclassical class I genes in different groups of mammals. Mol. Biol. Evol. 6: 559-579.
6. Kimura M, (1983). The Neutral Theory of Molecular Evolution. Cambridge Univ. Press, Cambridge.
7. Lawlor DA, Zemmour J, Ennis PD and Parham P, (1990). Evolution of class-I MHC genes and proteins: from natural selection to thymic selection. Annu. Rev. Immunol. 8: 23-63.
8. Nathenson SG, Geliebter J, Pfaffenbach GM and Zeff RA, (1986). Murine major histocompatibility complex class-I mutants: Molecular analysis and structure-function implications. Annu. Rev. Immunol. 4: 471 -502.
9. Ohta, T, (1983). On the evolution of multigene families. Theor. Pop. Biol. 23: 216-240.
10. Ohta T, (1991a). Role of diversifying selection and gene conversion in evolution of major histocompatibility complex loci. Proc. Natl. Acad. Sci. USA 88: 6716-6720.
11. Ohta T, (1991b). Multigene families and the evolution of complexity. J. Mol. Evol. 33: 34-41.
12. Ohta T, (1992). The nearly neutral theory of molecular evolution. Annu. Rev. Ecol. Syst. 23: 263-286.
13. Ohta T, (1995). Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci. J. Mol. Evol. 41: 115-119.
14. Ohta T and Ina Y, (1995). Variation in synonymous substitution rates among mammalian genes and the correlation between synonymous and nonsynonymous divergences. J. Mol. Evol. 41: 717-720.
15. Parham P and Ohta T, (1996). Population biology of antigen presentation by MHC class I molecules. Science 272: 67-74.
16. Parham P, Adams EJ and Arnett KL, (1995). The origins of HLA-A, B, C polymorphism. Immunol. Rev. 143: 141-180.
17. Satta Y, O'hUigin C, Takahata N and Klein J, (1994). Intensity of natural selection at the major histocompatibility complex loci. Proc. Natl. Acad. Sci. USA 91: 7184-7188.
18. Thompson EA and Neel JV, (1996). Private polymorphisms: How many? How old? How useful for genetic taxonomies? Mol. Phyl. Evol. 5: 220-231.
19. Wolfe KH, Sharp PM and Li W-H, (1989). Mutation rates differ among regions of the mammalian genome. Nature 337: 283-285.