Enzymatic basis for the lack of oxamniquine activity in Schistosoma haematobium infections

Parasitology Research

Volumn 83, Issue 7, 1997, Pages 687-689

  Pica Mattoccia, L ^a   Novi, A ^a   Cioli, D ^a  

^a Institute of Cell Biology   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HYCANTHONE; OXAMNIQUINE;

ARTICLE; DRUG ACTIVATION; ENZYME ACTIVITY; ENZYME ISOLATION; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA HEMATOBIUM; SCHISTOSOMA MANSONI;

ANIMALS; BIOTRANSFORMATION; HYCANTHONE; MACROMOLECULAR SUBSTANCES; MALE; OXAMNIQUINE; SCHISTOSOMA HAEMATOBIUM; SCHISTOSOMA MANSONI; SCHISTOSOMICIDES; SPECIES SPECIFICITY;

SCHISTOSOMA; SCHISTOSOMA HAEMATOBIUM; SCHISTOSOMA MANSONI;

EID: 0030809413     PISSN: 00443255     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360050320     Document Type: Article

References (9)

1. Archer S, Yarinsky A (1972) Recent developments in the chemotherapy of schistosomiasis. In: Jucker E (ed) Progress in drug research. Birkhäuser, Basel, pp 11-66
2. Cioli D, Pica-Mattoccia L, Moroni R (1992) Schistosoma mansoni: hycanthone/oxamniquine resistance is controlled by a single autosomal recessive gene. Exp Parasitol 75: 425-432
3. Cioli D, Pica-Mattoccia L, Archer S (1995) Antischistosomal drugs: past, present and future? Pharmacol Ther 68: 35-85
4. Foster R, Cheetham BL (1973) Studies with the schistosomicide oxamniquine (UK-4271). I. Activity in rodents and in vitro. Trans R Soc Trop Med Hyg 67: 674-684
5. Pica-Mattoccia L, Cioli D (1985) Studies on the mode of action of oxamniquine and related schistosomicidal drugs. Am J Trop Med Hyg 34: 112-118
6. Pica-Mattoccia L, Lelli A, Cioli D (1981) Effect of hycanthone on Schistosoma mansoni macromolecular synthesis in vitro. Mol Biochem Parasitol 2: 295-307
7. Pica-Mattoccia L, Cioli D, Archer S (1988) Binding of tritiated hycanthone and hycanthone N-methylcarbamate to macromolecules of drug-sensitive and drug-resistant schistosomes. Mol Biochem Parasitol 31: 87-96
8. Pica-Mattoccia L, Cioli D, Archer S (1989) Binding of oxamniquine to the DNA of schistosomes. Trans R Soc Trop Med Hyg 83: 373-376
9. Pica-Mattoccia L, Archer S, Cioli D (1992) Hycanthone resistance in schistosomes correlates with the lack of an enzymatic activity which produces the covalent binding of hycanthone to parasite macromolecules. Mol Biochem Parasitol 55: 167-176